Heilemann Lab

We are excited to share our new preprint: iCLIP3 — an improved protocol for transcriptome-wide mapping of protein–RNA interactions at single-nucleotide resolution.

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

The gray planet symbolizes a cell that appears lifeless at first glance. Lectins, depicted as a UFO, illuminate and reveal its glycans, transforming it into a vibrant molecular landscape and highlighting the hidden complexity and biological significance of cellular nanoarchitecture.

Our Glyco-STORM paper is officially out in the 23 Feb 2026 issue of #AdvancedScience: doi.org/10.1002/advs....
Celebrating with the cover artwork🎉.
What looks gray and lifeless at first glance unfolds into complex molecular landscapes when revealed with lectin probes & super-resolution microscopy.

We’re still at the @biophysicalsoc.bsky.social
#bps2026 Meeting in San Francisco! Come visit us at Booth 630 and take a #cellfie with us! 📸! Interested in a fully funded PhD through IMPRS-CBP? This is your chance to meet us, ask questions, and learn more about #PhDpositions in Germany. #biophysics

⚠️ 1 week left for Pasteur Course "Advanced Bioimage Analysis With AI"! 👩‍🔬💻

Intensive course (June 1-5, Paris): theory + hands-on, AI focus in bioimaging.

📍 Institut Pasteur
🗣️ English
⏰ Deadline: March 1

🔬 Beginner basics, batch scripts, interactive sessions

👉 Apply: https://bit.ly/4c8rFKZ

Xiaofeng combined 2D live-cell single-particle tracking with 3D simulations to specifically measure the bacterial nucleoid accessibility and viscosity! Our preprint describes how these nucleoid properties respond to cellular processes! Code is available too.
www.biorxiv.org/content/10.6...

Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence!

www.nature.com/ncomms/edito...

@natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

PhD in Super-Resolution microscopy of clinical biopsies for precision medicine

We are hiring! We’re looking for a PhD candidate to apply super-resolution microscopy to clinical biopsies, bridging advanced imaging and precision medicine. Perfect for researchers passionate about microscopy and eager to make an impact in healthcare. Apply here: www.tue.nl/werken-bij-t...

We switch between targets using light ... more soon!

🔬we have been playing with 'an old tool from (DNA) chemistry' 🧪 and used that for DNA-based confocal/super-res microscopy ... these are the last recordings for the revision and were recorded last night ... 🙏 thanks to R1 for this suggestion:

Full Professor and Chair Laboratory of Biophysics We are looking for a Full Professor in the Biophysics chair group, part of Wageningen University & Research (WUR)

The Laboratory of Biophysics at Wageningen University & Research (NL) is looking for a new chair! Details here: www.wur.nl/en/vacancy/f...

Flyer with announcement of the FEBS advanced course in Amsterdam

Join us in Amsterdam for a FEBS advanced course on "Functional Imaging of cellular dynamics" from 31st of May - 6th of June 2026
Info: microscopy2026.febsevents.org

Directors

Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...

CELL MIGRATION LAB We study cell migration in health and disease

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶

Interested in cell-cell communication and microscopy? We are searching for a motivated postdoctoral researcher to join Münster! Please Apply! @uni-muenster.de

In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...

So very sad news. A brilliant mind. My thoughts are with his family.

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

Single Molecule Spectroscopy and Superresolution Imaging XIX, Conference Details View program details for BiOS conference on Single Molecule Spectroscopy and Superresolution Imaging XIX

On my way to #PhotonicsWest #SPIE #BIOS & exicted for the "Single Molecule Spectroscopy and Super-Resolution Microscopy" conf spie.org/PW26B/confer... @spie.org @picoquant.bsky.social

We present our work on smart STED microscopy for optical structural cell biology 👉🏻 www.nature.com/articles/s41...

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.

The gene-regulating proteins NONO and SFPQ assemble into ordered filaments - Communications Biology Filament formation of full-length NONO/SFPQ heterodimers was observed and structurally characterized in vitro which may provide a scaffold for gene regulation, paraspeckle formation and DNA double-str...

Much enjoyed this nice cryoEM study of NONO:SFPQ heterocomplex this morning, while it was snowing outside. So happy to read a paper in full again (only a handful of papers read in full in last weeks or even months ☹, and some were to review).

Short fatty acids, custom synthesized by engineered yeast 🧫
Here it is: doi.org/10.1038/s415...

🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬

A cool thing was the FRET-based diffusion analysis that allowed a separate analysis of MET receptor monomers and dimers👇🏻

Great work led by Yunqing Li @yunqingli.bsky.social & another great collaboration with Hartmut Niemann (Bielefeld). Funded by CRC1507 'Membrane-associated protein assemblies' @crc1507.bsky.social at @goetheuni.bsky.social 🙏

Receptor tyrosine kinases bind ligands and (often) dimerize. Yet how long, and how does that change their mobility? Using single-molecule FRET in living cells, we found that MET dimers 'socialize' for ~1 second while lowering lateral diffusion and confinement 👉🏻 doi.org/10.1002/smll...

⏰Call for Applications - Join Our Team and Help Shape Our Cluster

@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!