Are there any plans to extend the phoenix trail from Thame via Wheatley towards the edge of Oxford? That would be a nice addition of a proper traffic free greenway :)

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals Li and colleagues successfully generated bi-paternal mice that developed to adulthood by targeting 20 key imprinted loci. This study underscores imprinting gene abnormalities as the primary barrier to...

Wild: Viable mice from 2 sperms. Very involved - among other things, it requires making a "20KO" first - 20 different loci deleted/edited to avoid imprinting effects. And low survival rate, but proof of concept nonetheless.

www.cell.com/cell-stem-ce...

Die #Gentechnik Diskussion in Europa geht weiter. Plötzlich ist möglich, dass dieses Jahr über eine neue Regulierung für #CRISPR & Co. in der Pflanzenzüchtung entschieden wird.

Eine kompakte, gut verständliche, rechtliche und naturwissenschaftliche Einordnung dazu gibts in unserem neuen Beitrag
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5 Schlagzeilen, die man in 🇩🇪 nie lesen wird:

1.) Preisschock: D-Ticket über Nacht 9€ rauf

2.) 17 Mrd Subventionen - Zwingt der Staat uns ins Auto?

3.) Abzocke: Öffi-Einzelticket schon über 4€

4.) Über 400 Fahrradtote - wie die Behörden versagen

5.) An Kaufkraft gemessen: Sprit immer billiger

Could you consider creating other KO lines with edits in different positions/exons? Like other said, might be an issue with splicing/alternative exon usage etc.

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We're excited to release a new chapter of CRISPRpedia, our textbook-style resource on all things #CRISPR! Chapter 5 is on CRISPR & ethics. Explore here: innovativegenomics.org/crisprpedia/...

#STEMeducation #STEMed #bioethics #SciArt

Has anyone had success with any of the Cas9 fusions to promote HDR efficiency?