Jon Humphries

AI succeeds in diagnosing rare diseases An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning.

Nature news & views:
'AI succeeds in diagnosing rare diseases'
www.nature.com/articles/d41...

AI offers way to image and assess clinical cell samples The use of artificial intelligence in the clinic to image slides of cells enables the rapid assessment of cellular characteristics that might help with diagnostic decisions.

Nature news & views:
'AI offers way to image and assess clinical cell samples'
www.nature.com/articles/d41...

Bishop Island? Shipping them off to a resort and let the public decide?

Splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of Alport syndrome
insight.jci.org/articles/vie...

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics - Communications Biology Simultaneous mapping of tractions and molecular tension reveals how cells coordinate forces across scales, from whole-cell mechanics to polarized force transmission within individual focal adhesions.

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics
www.nature.com/articles/s42...

Paxillin is our #CellLineOfTheWeek! 🧫

Our stem cell lines & plasmids are available for just the cost of shipping to lower the barriers to scientific discovery and breakthroughs.

🚛 Hosted and distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

Well at least that fits with your experience. Thanks for sharing

Thought HeLa would be faster 🤷‍♂️

Do you provide a stimulus to alter proliferation? Interested in the idea for our students too 😉👌

This looks really interesting from the Scott Holley lab. They do proteomics of itga5 complexes in zebrafish

Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites Integrins are key plasma membrane proteins that mediate cell-ECM adhesion and communication, and they rely on a conformational change for their activa…

Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites
www.sciencedirect.com/science/arti...

FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions
www.nature.com/articles/s41...

Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4 - Purinergic Signalling Interactions of effector T cells with laminins during their trafficking across basement membranes play a crucial role in the development of the adaptive immune response and inflammatory diseases. Howe...

Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4
link.springer.com/article/10.1...

The abstract submission deadline for our upcoming 'Imaging Cell Dynamics' meeting is this Friday. We still have a few places remaining so apply now to secure your spot!

Find out more at:
www.biologists.com/meetings/jcs...

#imaging #microscopy #cellbiology

Webinar at EMBL's European Bioinformatics Institute (EMBL-EBI).Mapping biology in space: a guide to technologies and workflows in spatial transcriptomics.18 February 2026. 14:30 - 15:30 GMT. Valeriy Pak, EMBL Heidelberg.

Join us next week for the first free webinar in our spatial transcriptomics series: www.ebi.ac.uk/training/eve...

Valeriy Pak, Predoctoral Fellow at @embl.org, presents 'Mapping biology in space: a guide to technologies and workflows in spatial transcriptomics' on 18 February | 14:30 UK time.

🖥️🧬

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

UKRI increases minimum stipends for PhD students National funder commits to another above-inflation increase of almost 5 per cent

UKRI increases minimum stipends for PhD students share.google/4HamGmefmp2N...

Fantastic effort from everyone involved but especially Ernest and Sergey. @ernestiu.bsky.social

Fantastic news Ernest! well done

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the…

My PhD work is finally out! Huge thanks to all the collaborators who made this possible 🎉
Looking forward to the next chapter as a postdoc 😁
www.sciencedirect.com/science/arti...

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in lamellipodia via CaMKII and TEM4,...

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...

Fill out our community survey to help shape the future of JCS Journal of Cell Science logo Line drawing of a group of people with speech bubbles above their heads

After 15 years as Editor-in-chief (EiC), Michael Way @drmichaelway.bsky.social will be stepping down at the end of 2026 & we are seeking feedback from the cell biology community as part of the consultation process for appointing a new EiC.
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9

Leupaxin inhibits the durotaxis and mechanosensitivity of metastatic breast cancer cells https://www.biorxiv.org/content/10.64898/2026.02.03.703253v1

Unlocking TIL Therapy: A New Era for Melanoma Care in the UK TIL (Tumour-Infiltrating Lymphocyte) therapy is a transformative, cell-based immunotherapy approach now entering clinical practice for melanoma. This national summit brings together UK and internation...

📣 Final agenda confirmed - only 5 weeks to go!

Join us on 𝟭𝟭 𝗠𝗮𝗿𝗰𝗵 𝟮𝟬𝟮𝟲 in Manchester 🐝 for our inaugural TIL Summit: Unlocking TIL Therapy – A New Era for Melanoma Care in the UK.

Kindly sponsored by The Christie Charity.

Space limited - so don't miss out! For further information & to register:

Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...

Still time to register for this. Lots of fantastic talks lined up

Peoples Choice Awards | Liverpool City Region Combined Authority The People's Choice Awards is the ultimate fan-voted award show, honoring the best in movies, music, television, and more. Celebrate the fan favorites and vote now at the official People's Choice Awar...

Some blatant self promotion for my better half and an award nomination for her work at Alder Hey Children's Hospital.

The programme supports >11,000 children & young people in their care each year, through a range of creative patient led programmes.
www.liverpoolcityregion-ca.gov.uk/peoples-choi...

Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK The focal adhesion protein vinculin affects the dynamics of the actin cytoskeleton, and reorganization of the actin cytoskeleton is an energetically demand

Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK
rupress.org/jcb/article/...

Three UK research councils suspend funding opportunities Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts

What's this about then?
www.timeshighereducation.com/news/three-u...

International Developmental Mechanics Seminar Series Please fill out the following survey if you are interested in the 2025-2026 International Zoom Seminars on Developmental Mechanics.

🎉 The Developmental Mechanics Seminar Series is back!
🗓️ Thurs, Jan 22
🎙️ Opening talks:
🧬Guy Tanentzapf (UBC)
— How cell adhesion molecules wire into the cytoskeleton
🌀Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
— Mapping tissue mechanics with Brillouin microscopy