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Alex Shackman

@ajshackman

Laboratory for Affective & Translational Neuroscience, University of Maryland | shackmanlab.org | affective neuroscience | "pessimism of the intellect, optimism of the will.”

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Latest posts by Alex Shackman @ajshackman

Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities.

But the process that they have put down on paper is a sham.

It’s important to know NIH is not following its own guidance. Here’s why:

🧵1/

06.03.2026 14:35 👍 192 🔁 121 💬 4 📌 10

i second oli's question - which movie?

06.03.2026 16:15 👍 1 🔁 0 💬 1 📌 0
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Integrating Physical Activity Into Routine Psychiatric Care This narrative review synthesizes evidence on integrating physical activity and reducing sedentary behavior into adult psychiatric care for individuals with severe mental illness.

jamanetwork.com/journals/jam...

05.03.2026 15:16 👍 1 🔁 1 💬 0 📌 0

Manuscript peer review is not

1) journal club

2) dissertation committee meeting

3) zero sum grant award

4) mortal kombat

03.03.2026 23:44 👍 37 🔁 5 💬 1 📌 0

When bullshiters tell you they will soon be able to make "digital twins" of patients, remember articles like this about how hard it is to model a single cell.

28.06.2025 17:49 👍 59 🔁 19 💬 6 📌 1

Here is a link to a video of the speech.

xcancel.com/netflix/stat...

02.03.2026 12:31 👍 25 🔁 5 💬 1 📌 1
Today should be your 38th birthday..
When you lose your son you lose more than a child you lose a piece of your heart and your joy. Life is forever altered, and nothing can ever fill that space. Yet in my soul, he remains, my precious boy, forever loved. His laughter, his smile, and his love are woven into who I am. My love for him will never fade. Yor are my pride and my joy - you've made a change that cannot be broken..

Today should be your 38th birthday.. When you lose your son you lose more than a child you lose a piece of your heart and your joy. Life is forever altered, and nothing can ever fill that space. Yet in my soul, he remains, my precious boy, forever loved. His laughter, his smile, and his love are woven into who I am. My love for him will never fade. Yor are my pride and my joy - you've made a change that cannot be broken..

Alex's mom on his 38th birthday.

02.03.2026 00:24 👍 21280 🔁 5333 💬 472 📌 313
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We’re hiring!🔬The MAClab at Texas A&M is looking for a lab manager to join our team in College Station. If you’re organized, passionate about research, and interested in emotion and the brain, we want to hear from you!

🔗Apply at the link in our bio!
#PsychSky #PsychSciSky #neuroskyence #AcademicSky

24.02.2026 16:31 👍 3 🔁 6 💬 0 📌 1
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That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

01.03.2026 15:32 👍 1541 🔁 436 💬 40 📌 22

Technological and logistical tour de force, *but* what is the scientific or practical significance of showing that you can reliably classify/decode spontaneous pain in n=1, given hours of scanner data

01.03.2026 16:05 👍 1 🔁 0 💬 0 📌 0
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Personalized brain decoding of spontaneous pain in individuals with chronic pain - Nature Neuroscience Lee et al. show that personalized brain-decoding models derived from intensive longitudinal fMRI data can track spontaneous pain in individuals with chronic pain, highlighting the potential of precise...

#TeamWani www.nature.com/articles/s41...

01.03.2026 16:01 👍 1 🔁 0 💬 1 📌 0
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While we sit around to find out how bad exactly it all is, a bit of cheer: the best baguette of Paris competition was won by a Sri Lankan who appears to have started as a dish washer in restaurants and eventually trained as a Boulanger.

www.paris.fr/pages/la-mei...

28.02.2026 21:49 👍 6333 🔁 936 💬 79 📌 60
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A children's hospital is renamed for Dolly Parton and hopes to transform pediatric care in Tennessee Dolly Parton’s name might inspire full-throated sing-a-longs to her working woman’s anthem “9 to 5,” or evoke memories of thrilling days spent at her Dollywood theme park.

“Dolly Parton Children’s Hospital did not share how much Parton donated as part of the naming announcement. But Matt Schaefer, its president and CEO, said her support would ensure ‘every child who walks through our doors receives the treatment they deserve.’”

GOD BLESS DOLLY PARTON

01.03.2026 02:56 👍 13766 🔁 3024 💬 223 📌 301

Another day of repeating the mantra, there are no banned words, just words that will prevent an otherwise fundable application from being funded…

27.02.2026 12:24 👍 21 🔁 3 💬 0 📌 0

blood boiling

27.02.2026 13:02 👍 6 🔁 0 💬 0 📌 0
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Why I’m Not a Cognitive Psychologist... or a Behaviorist... or a Biologist “Science” is under increasing amounts of scrutiny. Concerns about reproducibility, reduced institutional support, and intensified competition has been highlighted in recent years, but segregated science endangers scientific discovery above all. Segregated science can be interdisciplinary (biology vs psychology) or intradisciplinary (behaviorism vs cognitive psychology). The advancement of science and public knowledge depends on the unification of all disciplines to better understand the phenomena scientists study. We suggest that engendering collaborations across scientific disciplines produces better-designed research and appropriate interpretations, and increases career-long success. I am not a cognitive psychologist, behaviorist, or biologist because I am a neuroscientist.

pubs.acs.org/doi/10.1021/...

25.02.2026 19:33 👍 1 🔁 0 💬 0 📌 0
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Has the time come to stop using control groups in trials of psychosocial interventions? An official website of the United States government

pmc.ncbi.nlm.nih.gov/articles/PMC...

25.02.2026 18:35 👍 0 🔁 0 💬 0 📌 0
JASP - A Fresh Way to Do Statistics JASP is an open-source statistics program that is free, friendly, and flexible. Armed with an easy-to-use GUI, JASP allows both classical and Bayesian analyses.

jasp-stats.org @jaspstats.bsky.social

24.02.2026 16:47 👍 0 🔁 0 💬 1 📌 0

Jasp is pretty good for this

24.02.2026 16:46 👍 0 🔁 0 💬 1 📌 0
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origins of MADRS-SR

24.02.2026 12:54 👍 0 🔁 0 💬 0 📌 0
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Back in business! @foxdotdrew.bsky.social @sgrogans.bsky.social (note hard to see menu on the far left). wanna plot data OLS vs Spearman/Rank vs Robust/Tukey? Dynamically censor points (for thinking about leverage, not p-hacking)? Try Scatterize 3!

24.02.2026 12:35 👍 2 🔁 0 💬 1 📌 0
Scatterize 3

Slightly apropos of this: In honor of Drew Fox's birthday, this weekend I (finally!) resurrected scatterize as a browser-only setup, in the hope that it may live as HTML and javascript. It probably still has a few rough edges, but give it a try!

njvack.github.io/scatterize/

23.02.2026 20:07 👍 2 🔁 1 💬 1 📌 0

give em hell 75 !

24.02.2026 12:32 👍 1 🔁 0 💬 0 📌 0

Kurt Vonnegut stop being so applicable to all time periods of American life, you can’t do that Kurt Vonnegut, your insights are too evergreen Kurt Vonnegut

21.02.2026 13:35 👍 10129 🔁 2943 💬 145 📌 58

now walking the poor dog!

21.02.2026 15:10 👍 0 🔁 0 💬 0 📌 0
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6/n. PPS: An unexpected bonus: 13-y.o. asks what I'm doing and why I'm grinning so much. Lower right panel by Hannah Shackman. Neg exp framing: 'weed smoking (NumTimes) among 8th graders'

21.02.2026 15:08 👍 0 🔁 0 💬 1 📌 0
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5/n. PS: One of the best parts of spending 10! years working on my PhD is that I regularly had the pleasure and the luxury of engaging in these sorts of stats rabbit holes and sharing the fruits of my labor w/ others. (Screen cap is archived Wisco stats page circa 2012)

21.02.2026 14:49 👍 0 🔁 0 💬 1 📌 0

4/n. sort, and which is routinely applied to similar real-world data (teen drinking, insurance claims, hospital stay length, etc.)

21.02.2026 14:47 👍 0 🔁 0 💬 1 📌 0

3/n. do a little Sat morning geek-out detective work...when I should be walking the dog barking downstairs. I think what we actually want is a Tweedie regression, which is fun to say aloud, which is designed to capture mixed distributions of this

21.02.2026 14:47 👍 0 🔁 0 💬 1 📌 0

2/n. We ended on an equally inelegant 2-stage "hurdle" approach: logistic regression of 0-vs-1+ . If signif, then followed by OLS linear on the GT 0 values (censor 0s). Blech. Skimming the primer paper, which features several 0-inflated distributions led me to

21.02.2026 14:46 👍 1 🔁 0 💬 1 📌 0