Ule Lab

What is the question? - Genome Biology Genome Biology -

A great read! link.springer.com/article/10.1...

Congrats Iosifina and Paulo, great team work!

Polyamine-dependent metabolic shielding regulates alternative splicing - Nature Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

www.nature.com/articles/s41...

Polyamines in the regulation of splicing (and potentially transciption dynamics)
From Carracedo lab.

Really cool to see this.

Time to figure out polyamines control molecular homeostasis, especially in the context of aging

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

PRMT activity promotes global 3’ UTR shortening in proliferating cells Protein methyltransferase (PRMT)-catalysed arginine methylation is a widespread post-translational modification that regulates numerous RNA-binding proteins and frequently becomes dysregulated in canc...

Very pleased to share this new preprint from our group, uncovering how alternative polyadenylation is regulated by arginine methylation: PRMT activity promotes global 3’ UTR shortening in proliferating cells www.biorxiv.org/content/10.1...

Carlos Santana (UPenn) argues that optimal openness is not maximum openness. Openness is one of the core values that govern science. Trade offs apply depending on contexts. #ScienceAndValues #philsci #philsky