Renátó Kovács

www.biorxiv.org/content/10.6... comparison of commercially available #Saccharomyces #mead yeasts.

Our new preprint w/ @balintnemeth.bsky.social and colleagues compares 13 mead #yeast strains for their phenotype, genome, and presents data on metabolites in experimental mead fermentations.

🧫🦠 How accessible are fungal diagnostics in Australia and New Zealand?

This survey reveals strengths, gaps, and delays driven by centralised testing, highlighting urgent needs in β-D-glucan access and resistance surveillance

👉 www.sciencedirect.com/science/arti...

Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses Mortality from invasive aspergillosis remains unacceptably high, and the currently recommended treatment of triazoles is further challenged by rising resistance to these first-line agents. A previous ...

Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses

Tom Harrison & Tom Walsh

www.thelancet.com/journals/lan... (paywall) #IDSky #TxID

A Calcineurin Inhibitor as an Enhancer of Candida Susceptibility to Anidulafungin The increase in invasive candidiasis caused by emerging Candida species presents a significant medical challenge due to their resistance to conventional antifungal treatments. Exploring novel therapeu...

A Calcineurin Inhibitor as an Enhancer of Candida Susceptibility to Anidulafungin | ACS Omega pubs.acs.org/doi/10.1021/...

Biofilms: from the cradle of life to life support npj Biofilms and Microbiomes - Biofilms: from the cradle of life to life support

We have just published “Biofilms: from the cradle of life to life support” in @natureportfolio.nature.com #Biofilms & #Microbiomes. It highlights how #bioinformatics and #microbiology come together to study biological systems & food-associated biofilms. Stellar multidisciplinary team! rdcu.be/e0esg

graphical abstract. Left is a fungal cell surrounded by bacteria, and the Hog1 cascade is turned on. Right is a fungal cell covered in mannan fibrils that prevent IgA and caspofungin and increase CLR recognition by macrophages

Candida albicans is usually hanging out with bacterial neighbors, so what happens to the fungus during co-culture?
The bacteria secrete metabolites that induce massive cell wall remodeling that change immune recognition and drug resistance. Read more in our new paper: www.cell.com/current-biol...

The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice Invasive candidiasis is a life-threatening infection associated with high morbidity, mortality and healthcare costs in both general and critical care settings. Timely diagnosis and adequate antifunga....

Early mycological clearance in uncomplicated candidaemia can improve outcomes, reduce ICU stay, and lower healthcare costs. Timely antifungal therapy is key. Read more: doi.org/10.1111/myc.... @martinhoenigl.bsky.social

#Candidaemia #AntifungalTherapy #InfectiousDiseases #ICU #Healthcare

Phylogenomic diversity of clinical Saccharomyces cerevisiae and the prevalence of probiotic-derived isolates in a tertiary care center in Hungary | Microbiology Spectrum Saccharomyces cerevisiae is best known for its beneficial role in beer, bread, and wine production and is generally considered a harmless microbe. A specific subtype, S. cerevisiae var. “boulardii,” i...

journals.asm.org/doi/10.1128/... Phylogenomic diversity of clinical #Saccharomyces cerevisiae and the prevalence of probiotic-derived isolates in a tertiary care center - our new paper in collab with @renatokovacs1.bsky.social , with PhD students @balintnemeth.bsky.social and Andrea Harmath! #yeast

New in JB: Black and Wakeman review the challenges of treating polymicrobial infections in various body sites, a topic near and dear to my heart.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Risk factors associated with progression to clinical Candida auris infection among adults with previous colonization—Florida, 2019–2023 We investigated factors associated with clinical progression of Candida auris cases following documented colonization among Florida patients. These finding

Risk factors associated with progression to clinical Candida auris infection among adults with previous colonization—Florida, 2019–2023

academic.oup.com/cid/advance-...

The effects of tyrosol on yeasts: an overview of current knowledge - Applied Microbiology and Biotechnology Abstract Quorum sensing is a cell density-dependent microbial communication form, which can regulate several microbial properties, including virulence, biofilm formation and cell–cell competence. The ...

Our latest review on the effect of tyrosol in yeast has just been published. 🔥🔥🔥🍄
link.springer.com/10.1007/s002...

And another:

Name changes for fungi of medical importance, 2022–2024 | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...

Very happy to have our preprint published in Microbiological Research now doi.org/10.1016/j.mi..., we had additional help from Steven during the revision to get this over the line @chitinette.bsky.social @theafg.bsky.social @uniofaberdeen.bsky.social

A clinical practice guideline for tuberculous meningitis Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal mana...

A clinical practice guideline for tuberculous meningitis

Tuberculous Meningitis International Research Consortium

www.thelancet.com/journals/lan... 🔒

Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi The fungus Candida albicans commensally colonizes mucosal surfaces in healthy individuals but can cause both superficial mucosal and life-threatening disseminated infections. The balance between comme...

Today is a good day to read our preprint about Candida albicans interactions with its neighbors! www.biorxiv.org/content/10.1... led by the amazing Faith Davis and a fantastic team of collaborators @kylaost.bsky.social @shannonrighi.bsky.social @balunaslab.bsky.social @tuowang.bsky.social

A global perspective on autoinducer-2-mediated cell communication in prokaryotes Biological sciences; Molecular biology; Microbiology

A global perspective on autoinducer-2-mediated cell communication in prokaryotes

- in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

📣 ERC Synergy Grant 2026 call for proposals is now open!

Application deadline 5 November 2025.

📝 Groups of 2-4 researchers
📝 Jointly addressing ambitious problems & with different skills

Application portal 👉 europa.eu/!XpwptY
General info 👉 europa.eu/!PR6gt8

#ERCSyG #FrontierResearch

Our new paper in JEADV describing four cases of TMVII infection in the UK:

doi.org/10.1111/jdv....

Bloodstream infections caused by yeast rose by 4% in 2024, compared to 2023 (C. auris)

Professor Andy Borman, Head of the Mycology Reference Laboratory, UKHSA Our surveillance shows that serious fungal infections are having an increasing impact on public health. UKHSA is working with the NHS to explore the reasons behind the rise in serious yeast infections, but factors such as an increase in people who are immunocompromised and the number of people receiving complex surgeries may be playing a part.

🆕 Our latest data shows that bloodstream infections caused by yeast rose by 4% in 2024, compared to 2023.
These infections are typically acquired in a hospital setting from yeasts found naturally on patients' skin or in our intestinal tracts. 🦠🧍
📰🔗 www.gov.uk/government/n...

🦠 Fungi Under Fire in Peru 🇵🇪

🧪 Microscopy? Widespread.
💊 Antifungals? Some gaps.
🧬 Advanced tools? Still growing.
💡 A call for smarter investment in fungal care → journals.asm.org/doi/10.1128/...

@jmaquera2 @olivercornely.bsky.social

Graphical abstract

Antifungal therapy in Candida infective endocarditis: a comparison of echinocandins & other treatment regimens in a nation-wide cohort study

In this 🇸🇪 registry study, no dif in in-🏥 mort, relapse rate, or 1-yr mort in pts w/ echinocandin-based Rx vs other regimens

academic.oup.com/cid/advance-...

Invasive candida in the abdomen: how to differentiate infection from colonization Intra-abdominal candidiasis (IAC) is a serious complication in critically ill patients, particularly after abdominal surgery or trauma. Differentiating Candida colonization from invasive infection ...

Invasive candida in the abdomen: how to differentiate infection from colonization
Corentin Deckers, et al.
Expert Review of Anti-infective Therapy, 2025
doi.org/10.1080/1478...

Candida Endocarditis: current perspectives on diagnosis and therapy Candida infective endocarditis (CIE) is a rare but potentially devastating condition. Although it accounts for only 1-1.5% of infective endocarditis cases, CIE carries a high mortality rate (36-49%) a...

Candida Endocarditis: current perspectives on diagnosis and therapy

Ben-Ami Ronen, Bassetti Matteo, Bouza Emilio, Kosman Alex, Vena Antonio on behalf of @efisg-escmid.bsky.social

www.clinicalmicrobiologyandinfection.com/article/S119... #MedMycoSky #IDSky

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge | NEJM Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge

@grthompsonmd.bsky.social and Angel Desai

www.nejm.org/doi/full/10....

Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance The global burden of bloodstream infection (BSI) due to Candida, and species previously classed as Candida (Candida-like species) is substantial. Recent emergence of Candida auris, fluconazole-resista...

Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance - Journal of Infection www.journalofinfection.com/article/S016...

Commensalism and pathogenesis of Candida albicans at the mucosal interface Nature Reviews Microbiology - In this Review, Hube and colleagues overview the commensal and pathogenic lifestyles of Candida albicans, focusing on how the fungus transitions between these two...

Commensalism and pathogenesis of #Candida albicans at the mucosal interface rdcu.be/eia8o

How does antifungal resistance vary in Candida (Candidozyma) auris and its clades? Quantitative and qualitative analyses and their clinical implications Candida auris is a multidrug-resistant yeast that emerged as a significant healthcare-associated pathogen. It is classified as an urgent threat to public health due to the high resistance to available...

How does antifungal resistance vary in Candida (Candidozyma) auris and its clades? Quantitative and qualitative analyses and their clinical implications
Kássia Jéssica Galdino da Silva, et al.
Clinical Microbiology and Infection, 2025
www.clinicalmicrobiologyandinfection.com/article/S119...

Current knowledge on the dual species interaction and biofilm between Aspergillus and Bacillus: exploiting molecular understanding toward applications The complex interaction between Aspergillus and Bacillus has been gaining attention with the evolution of their co-culture applications. Information reported on this interaction from different poin...

Current knowledge on the dual species interaction and biofilm between Aspergillus and Bacillus: exploiting molecular understanding toward applications

-in Critical Reviews in Microbiology

www.tandfonline.com/doi/full/10....

The Paediatric European Confederation of Medical Mycology (ECMM) Quality (Paed‐EQUAL) Candida Score for the Management of Candidaemia in Children and Neonates Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of nov...

The Paed-EQUAL Candida Score helps manage candidaemia in children & neonates by improving guideline adherence & antifungal stewardship. With rising fluconazole resistance, this tool is crucial. Learn more: onlinelibrary.wiley.com/doi/10.1111/... #PaedEQUAL #Candida

Antifungal pipeline: New tools for the treatment of mycoses Fungal infections are becoming an escalating public health challenge, particularly among immunocompromised individuals. The partially limited efficacy…

Antifungal pipeline: New tools for the treatment of mycoses.
Focus on LMICs where many dont have access to current antifungals.

Updated maps on fungal availability in LMICS.

Thanks to a fantastic group of authors

www.sciencedirect.com/science/arti...