Based on this, we introduce Pinc (“probability of interface native contacts”): a simple and interpretable protein-protein interaction score for #alphafold (AF2/AF3) models.
Colab + CLI: git.mpi-cbg.de/tothpetroczy...
Feedback is appreciated.
#rstats
Pinc: a simple probabilistic AlphaFold interaction score. 👇Congratulations to @mbadonyi.bsky.social! 🎉💕
I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
visual for the job ad with black background
The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
💡With a #relational structure, programmatic access #API and improved search capabilities, CD-CODE 2.0 easily integrates into #datascience and digital #biology workflows, broadening its versatility and creating connections between condensate biology and #therapeutic development.
🔗 cd-code.org
CD-CODE is a great example of an interdisciplinary teamwork between computational and experimental biologists and software engineers! #Thankyou to all the authors of @tothpetroczylab.bsky.social, the biomolecular condensate community of @mpi-cbg.de, @hymanlab.bsky.social, and Dewpoint Therapeutics!
Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...
AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it.
Commentary in @natnano.nature.com
#nanotechnology
🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social
Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen
https://go.nature.com/40wXMx6
Big news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️
The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩
Big #thankyou to all the participants from
@hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜
Related science sketch video by @marionamec.bsky.social www.youtube.com/watch?v=0REv...
Congratulations to the amazing team of Chi Fung Willis Chow, @mscheremetjew.bsky.social, Soumyadeep Ghosh, @annaha-poetry-art.bsky.social and HongKee and Lena from the Scientific Computing Facility @mpi-cbg.de! 🎉
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...
One week left to apply to the Physics of Life MSc this year! Students learn first-class research skills and can also avail of #scholarships to aid their studies.
Learn more and apply: physics-of-life.tu-dresden.de/career-educa...
#internationalstudents #MSc #EnglishMSc #Physics #studyabroad
Exciting that CD-CODE is now connected to THE go-to resource for everything protein-related!
It's a great step forward, directing further developments and outlook for our project @tothpetroczylab.bsky.social @mscheremetjew.bsky.social 🥳
We conclude that new IDR-specific features and paradigms are needed to accurately classify disease mutations within those regions. Disorder-to-order transitions predicted by AlphaFold3 and motif predictions (e.g. by SHARK-capture) may aid structure-based variant interpretation.
The distance to the second Methionine discriminates between pathogenic and benign variants associated with the N-Methionine site.
Mutations at the N-Methionine site are prevalent. Look at the surprisingly high peak at position 1.
Most mutations in disordered regions are benign but ~12% of pathogenic mutations fall within a disordered region.
The correlation between the disorder predictors is low.
It depends which disorder definition (score) is used. Only 7% of residues are consistently predicted as disordered across five different disorder prediction tools. flDPnn under predicts disorder compared to other methods.
State-of-the-art VEPs tools have lower sensitivity but higher specificity for variants in disordered regions.
Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swlenz.bsky.social and WillisChow @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social bmcgenomics.biomedcentral.com/articles/10....
New Publication of the @tothpetroczylab.bsky.social: The group found that prediction tools are less sensitive in intrinsically disordered regions of proteins (IDRs). Since they are common & important, new methods tailored to these regions are needed. bmcgenomics.biomedcentral.com/articles/10....
logo with a shark
The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...
You can download my protein structure-inspired artwork from pdb webpage:
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
