Sophie Jean Walton 's Avatar

Sophie Jean Walton

@sophiejwalton

Stanford Biophysics PhD Student with Dmitri Petrov and Ben Good. evolution, ecology, genomics, microbiomes, biophysics :) she/her https://sophiejwalton.github.io

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18.08.2023
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Latest posts by Sophie Jean Walton @sophiejwalton

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Amy Goldberg, PhD - Join The Goldberg lab is moving to UCLA summer 2025, and recruiting postdocs and graduate students. We are a computational lab with occasional wet lab or field collaborators. We will be located in the Depa...

The Goldberg lab at UCLA is hiring one or more postdocs. Flexible start date.

We develop methods to study population genetics of humans, our primate relatives, and our pathogens.

www.goldberglab.org/join

05.03.2026 21:10 πŸ‘ 22 πŸ” 24 πŸ’¬ 1 πŸ“Œ 0
BAPG Spring 2026 Bay Area Population Genomics Conference

The next BAPG has been announced! April 11 at Davis organized by the inimitable @jrossibarra.bsky.social! bapg-conference.github.io

19.02.2026 18:33 πŸ‘ 18 πŸ” 14 πŸ’¬ 0 πŸ“Œ 1
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An NIH-funded postdoctoral position is available in my lab.

The project focuses on the structural and mechanistic basis of antibody recognition of M and M-like proteins of Strep A (Streptococcus pyogenes).

10.02.2026 18:36 πŸ‘ 1 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

12.02.2026 19:18 πŸ‘ 53 πŸ” 95 πŸ’¬ 0 πŸ“Œ 0

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

29.01.2026 15:03 πŸ‘ 42 πŸ” 37 πŸ’¬ 1 πŸ“Œ 2
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Warm waters undermine cryptic female choice Read the free Plain Language Summary for this article on the Journal blog.

New paper out in @funecology.bsky.social y.social: Warm waters undermine cryptic female choice! We find ovarian fluid only has a positive effect on sperm function at colder temperatures and that sneaker males have faster sperm than dominant nesting males at warmer temperatures. (1/3)

29.01.2026 16:33 πŸ‘ 23 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0

How does the strength of genetic drift evolve over long times?

New preprint out πŸ‘‡

www.biorxiv.org/content/10.6...

27.01.2026 23:20 πŸ‘ 24 πŸ” 14 πŸ’¬ 0 πŸ“Œ 0

another banger from @joaoascensao.bsky.social

27.01.2026 21:36 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Linking genomic and phenotypic traits to interaction outcomes in a synthetic phyllosphere community https://www.biorxiv.org/content/10.64898/2026.01.16.699983v1

22.01.2026 13:30 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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NSF seeks public input on its Fiscal Year (FY) 2026–2030 NSF Strategic Plan

The NSF strategic plan FY 2026-30 is available for public comment until Jan 27. Please make your voice heard! www.nsf.gov/od/updates/n...

17.01.2026 23:12 πŸ‘ 13 πŸ” 14 πŸ’¬ 0 πŸ“Œ 0
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I'll be presenting my work tomorrow morning at #PAG33! Stop by Pacific C (Comparative Genomics - Animals) @9:16am to learn about structural variation of swordtail Y-chromosomes and alternative reproductive tactics.

10.01.2026 06:15 πŸ‘ 8 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Excited to present at #PAG33 on the dynamic evolution of a balanced polymorphism. We've uncovered unexpected patterns using long-read sequencing and other fun methods.

Talk: Saturday @8:40am in Pacific C (Comparative Genomics - Animals)
Poster: Monday @10-11:30am in Golden State Ballroom (P216)

09.01.2026 22:11 πŸ‘ 15 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1

the spectrum of queer experience is vast and complex, and none of us know what's going on inside families that are not our own

but my feed is full of media outlets describing a woman with a very-much-living-and-in-the-picture wife first and foremost as though she was a man's widow, and I just

08.01.2026 22:06 πŸ‘ 3306 πŸ” 754 πŸ’¬ 19 πŸ“Œ 12
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Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.

Happy that our work on the evolution of Yellowstone cyanobacteria is now published in @elife.bsky.social: doi.org/10.7554/eLif...! Did a lot of work in revisionβ€”many thanks to the anonymous reviewers for great suggestions! Also see the eLife digest for a summary: elifesciences.org/digests/9084...

31.12.2025 21:15 πŸ‘ 43 πŸ” 14 πŸ’¬ 0 πŸ“Œ 2
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Extensive recombination, selection, and asexual blooms shape the diversity of the dominant clade of Prochlorococcus The tiny and enormously abundant marine cyanobacterium Prochlorococcus marinus contains many levels of population structure, with sequenced isolates spanning four orders of magnitude of diversity. It ...

New preprint to close out the year! Led by Alana Papula and together with Daniel Fisher, we used single-cell genomes to infer the evolution of Prochlorococcusβ€”one of the most abundant and genetically diverse bacteria on Earth. Check it out here: doi.org/10.64898/202...

31.12.2025 20:49 πŸ‘ 19 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0
Home - ProbGen 2026 Your Site Description

The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31

probgen2026.github.io

18.12.2025 17:09 πŸ‘ 16 πŸ” 18 πŸ’¬ 1 πŸ“Œ 0
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Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...

My first lead author paper is out with Ben Kerr and @alisonfeder.bsky.social! We found that making an antiviral too strong can sometimes make resistance easier to evolve. This has implications for how we design drugs, choose doses, and think about viral evolution in the face of treatment. (1/n)

08.12.2025 17:14 πŸ‘ 79 πŸ” 31 πŸ’¬ 4 πŸ“Œ 3
BAPG Fall 2025 Bay Area Population Genomics Conference @ Stanford

BAPG 2025 was a blast. Looking forward to seeing folks in Davis in Spring 2026! bapg2025.github.io/bapg2025stan...

07.12.2025 03:58 πŸ‘ 9 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
BAPG Fall 2025 Bay Area Population Genomics Conference @ Stanford

Super excited about our schedule for BAPG at stanford on Dec 6. bapg2025.github.io/bapg2025stan... Amazing talks, a fabulous keynote, a lively poster session. A brilliant and interactive community. What’s not to love? 1/2 @sophiejwalton.bsky.social

24.11.2025 22:54 πŸ‘ 15 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1
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Registration for BAPG 2025, Stanford Dec 6 2025 Talk submissions are now closed, but poster submissions are still open.

Please note that we already have 130+ people signed up and we will limit the sign up at 160. Don’t dawdle If you want to attend. Registration is free but required. forms.gle/M5BSyAaeUggn...

24.11.2025 22:54 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

We have 115 people signed up already for BAPG! Great representation across career stages too. If you want to attend don't forget to sign up. It is free but required. @sophiejwalton.bsky.social and I are looking through the wonderful talk submissions and will announce the talks shortly. Stay tuned!

20.11.2025 18:29 πŸ‘ 8 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation The extent to which adaptation can be predicted, particularly for traits with complex genetic bases, is unknown. Here, we leveraged a model complex trait, model species, and high-powered longitudinal ...

Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...

18.11.2025 00:14 πŸ‘ 64 πŸ” 30 πŸ’¬ 2 πŸ“Œ 3
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Dynamics of dN/dS within recombining bacterial populations The ratio of nonsynonymous to synonymous substitutions (dN/dS) encodes important information about the selection pressures acting on protein-coding genes. In bacterial populations, dN/dS often decline...

The first is from former PhD student Zhiru Liu @zzzhiru.bsky.social (now in @bengrbm.bsky.social's group @ MSK) examining the long-term patterns of selective constraint – measured by the classical ratio of nonsynonymous to synonymous mutations (dN/dS) – within recombining populations of bacteria.

16.11.2025 15:26 πŸ‘ 16 πŸ” 9 πŸ’¬ 2 πŸ“Œ 0
BAPG Fall 2025 Bay Area Population Genomics Conference @ Stanford

don't forget to register for BAPG at Stanford on Dec 6! @petrovadmitri.bsky.social and CEHG are hosting. talk submissions close on Nov 16 - bapg2025.github.io/bapg2025stan...

docs.google.com/forms/d/e/1F...

13.11.2025 18:55 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Beyond excited to share my PhD work thus far, now up as a preprint! We found that a transposable element insertion is responsible for the recent evolution of an novel color trait. Feeling thankful to everyone who has helped in this project and thrilled to continue learning about "sparkle"!

12.11.2025 22:58 πŸ‘ 34 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0

i will never stop laughing

12.11.2025 22:24 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thank you!

12.11.2025 16:05 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

And of course thank you to @benjaminhgood.bsky.social and @petrovadmitri.bsky.social for mentoring me through this adventure. n/n

11.11.2025 17:14 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Thanks to all my amazing collaborators! @ksxue.bsky.social , Jonas and Richa were instrumental to setting up this project! Also, huge shout out to Qing, @hgellert.bsky.social and Chih-Fu who contributed to the analysis and experiments. (20/n)

11.11.2025 17:14 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This suggests that conspecific strains can behave more like ecological species when competing within larger communities, even when their genomes appear to evolve as a single biological species. (19/n)

11.11.2025 17:14 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0