Sreeram Peela

What is the best strategy to win any contest?

Eliminate your opponents of course.

Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.

www.biorxiv.org/content/10.1...

CDC reports highest number of pediatric influenza-associated deaths since 2009-10 Pediatric influenza-associated deaths for the 2024-25 season were second-highest recorded since becoming notifiable in 2004.

🚨 ALERT: After the 2nd deadliest pediatric flu season in 20 years with 280 child deaths mostly unvaccinated, next year’s flu could be even worse without urgent action. Is the US ready for another pediatric flu crisis? Vaccines save lives
#MedSky
#FluSeason2025 #VaccinateKids #PublicHealth

Our work involved comparative genomics of neglected pathogen Burkholderia pseudomallei. This is my first paper in bacterial genomics, with focus on variant analysis and orthologous protein clusters. Glad to be a part of the team..

Glad to share that our paper under the guidance of Sujatha Sistla has been accepted in Journal of Medical Microbiology (Microbiology Society).

two weddings and one more finalised, finally a job for my wife (again thanks to Dr. Debarka). I am happy now and confident about the years to come..
#review2024 #welcoming2025
what are the best (and worst) things that happened this year for you..?

release of arrears by ICMR (though 2 months stipend is still pending 😅),

crossing 50+ citations for my papers, applied for > 200 positions abroad (with no luck),

job in a comp bio lab (grateful for the oppurtunity by Debarka Sengupta ) (=> learning lots about ML, DL and comp bio),

first genomics paper being communicated (10 months into peer review😒),

This year marked a lot of firsts in my career and life..

The story behind Sylph, from @jimshaw.bsky.social . It's quite inspiring to read.

jim-shaw-bluenote.github.io/blog/2024/de...

Deep Learning in Genetics and Genomics Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications, the intersection of deep learning and genetics opens up new avenue

My first book chapter has been published..
In the chapter, I introduced key genetics and genomics concepts for biologists and computer scientists..please recommend it to your librarians..
#book #ddeplearning #genomics #biology
shop.elsevier.com/books/deep-l...

Comparative pangenome analysis of major pneumococcal genotypes from India Background Pneumococcal genomes are highly dynamic with varying core genome sizes. The genotype classification system, Global Pneumococcal Sequence Clusters, identified patterns within genotype and an...

Comparative pangenomes of key pneumococcal genotypes reveal distribution of antibiotic resistance genes in the core genomes.
In this preprint, I analysed >600 genomes collected from India and created pangenomes for each major pneumococcal genotype. #pangenomes #bacteria
doi.org/10.1101/2024...

Pre- & post-vaccine trends in pneumococcal serotypes & antimicrobial resistance patterns - Indian Journal of Medical Research [article]

ijmr.org.in/pre-post-vac...
Excited to share my recent publication on changing trends of pneumococcal serotypes and AMR after PCV13 introduction in our geographical region
#AMR #VACCINE #PNEUMOCOCCI

Scientific method: Statistical errors - Nature P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume.

www.nature.com/articles/506...
The fallacy of p values..a significant part of our research uses p value..but with very little knowledge of how to interpret it
#statistics #pvalue #science

😆

Nice to see a platform to connect with peers, and without ads or political posts..hope the trend continues..crossed 100 followers today..
#bluesky #research #biology

Please include me in the list. My focus is on microbial genome evolution..

Well..is it good or bad for "research productivity"? 😜

EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

Wish I could apply, but still waiting for journal peer reviews to complete 😅

A gentle introduction to pangenomics https://academic.oup.com/bib/article/25/6/bbae588/7902219

Please do add me..

While pangenomes are a good way to go..don't we increase too much data for a supposed "reference" genome? I would rather work with best draft genome (based on ancestry) and try to identify snps from 100k databases..thoughts??

Please include me too..

Aird Lab

Hello to so many new followers! We recently received fundable scores on 2 R01s and are actively recruiting multiple postdocs. The broad theme of the lab is cancer cell metabolism, and I tailor projects to the postdoc’s scientific interests and career goals. See more: Airdlab.com

I agree..but to reach out to bigger (and not so technically aware) audience..I would stick to NGS..for illumina..but will always start my sessions with pyroseq and then describe SBS.

UK Biobank study, which has performed serial cognitive testing/brain MRI predating pandemic, examined ~800 people w/ & w/o #COVID19: those who’d been infected had more brain shrinkage & cognitive decline. Still true even after excluding those hospitalized.

#MedSky

www.nature.com/articles/s41...