REMAP Therapeutics

Psychedelics & Pain Association community Psychedelics & Pain Association community home page

The Psychedelics & Pain Community on Circle for patients, facilitators, healthcare providers and others interested in how psychedelics can be effective tools for those living with pain conditions.
•access to PPA’s research database
•moderated w/ password-protection
community.psychedelicsandpain.org

Well understood & supported, Prof, but tragic nonetheless…

To my American colleagues: sorry, I won't be visiting the USA this year. Logic says we should support you and your great science, but with the continued attacks against Canada, it's become emotional. I'll send trainees if they want to go, but also offer them alternatives in Canada, Europe and Asia.

Gut Bacteria Are Making a Sugar That Attacks the Brain The mice in Aaron Burberry's lab at Case Western Reserve University kept dying. Genetically, they were identical to mice at other institutions around the

Gut Bacteria Are Making a Sugar That Attacks The Brain | #ALS #FTD

#Prostaglandin agonists produce an unexpected #analgesiceffect and prevent chronic postsurgical pain (#CPSP) in this #mousemodel

https://www.bjanaesthesia.org/article/S0007-0912(25)00740-8/fulltext

Psychedelics & Pain Association community Psychedelics & Pain Association community home page

The Psychedelics & Pain Community on Circle for patients, facilitators, healthcare providers and others interested in how psychedelics can be effective tools for those living with pain conditions.
•access to PPA’s research database
•moderated w/ password-protection
community.psychedelicsandpain.org

NIH shut out hundreds of young scientists from funding to start their own labs Special Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.

Excellent story from @aniloza.bsky.social and colleague at STAT on the MOSAIC program.

www.statnews.com/2025/12/08/t...

1/4

Psilocybin helps the brain unlearn fear by silencing specific neural pathways Scientists have observed how psilocybin rewires the brain to overcome fear. The drug coordinates the silencing of trauma neurons and the activation of safety signals to promote behavioral flexibility in mice.

Psilocybin helps the brain unlearn fear by silencing specific neural pathways

Bronze plaque saying "A Letter to the Future. Ok is the first Icelandic glacier to lose its status as a glacier. In the next 200 years all our glaciers are expected to follow the same path. This monument is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it. August 2019. 415ppm CO2"

TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque:
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".

Further evidence that widespread covid vaccination is better for everybody.

Melissa becomes third Category 5 hurricane of the extraordinary 2025 season Updates and summaries on tropical Atlantic activity... including easterly waves, tropical storms, subtropical storms, and hurricanes.

For only the second time in recorded history, an Atlantic season has produced three Category 5 hurricanes... the previous year was 2005. This puts 2025 in an elite class of hurricane seasons. It also means that nearly 7% of all known Category 5 hurricanes have occurred just in this year.
#Melissa

What do you think the findings of Zheng et al., published in @science.org’s #ScienceAdvances mean for the emotional experience of pain? Check out Qiufu Ma’s comment on this and his other #PapersoftheWeek picks here bit.ly/3LoHSjB #PRF

Welcome to the new Dark Ages. In one self inflicted blow the US is giving up on knowledge generation, technical innovation and medical advances for a generation or more. This is Trump and Vought. This is their doing.

Diagram of brain anatomy. We see the olfactory bulb in yellow attach to the amygdala also highlighted in yellow. In addition the thalamus and hippocampus (grey lavendar) are labeled. the background is a cream color.

🧠The Amygdala in the brain makes and regulates Emotions.

👃People with post-COVID smell loss show microstructural changes in their Amygdala and have higher depression and anxiety scores.

SARS-CoV-2 can affect smell & also emotions long term. buff.ly/904lVX4

#medsky 🛟😷🧪

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.

pubs.acs.org/doi/abs/10.1...

President Reagan's Radio Address on Free and Fair Trade on April 25, 1987 YouTube video by Reagan Library

So they didn’t like the ad. Let’s just post Reagan’s 5 min speech against tariffs as it appears on YouTube.

Over and over. On all platforms (some of y’all are still on X).

*1981 Sherrilyn horrified by 2025 Sherrilyn saying “let’s post Reagan’s speech.”

youtu.be/5t5QK03KXPc

Women are being erased at the Pentagon. Women are being erased from history. And now a woman has been erased from the desecrated White House.

Antarctica may have crossed a tipping point that leads to rising seas Scientists are beginning to understand the sudden loss of sea ice in Antarctica – and there is growing evidence that it represents a permanent shift with potentially catastrophic consequences

Antarctica may have passed a climate tipping point of no return, scientists are warning, with mounting evidence that a sudden slump in sea ice formation since 2016 is linked to human-induced ocean warming.

“their nanoparticle-based vaccine can effectively prevent melanoma, pancreatic and triple-negative breast cancer in mice. Not only did up to 88% of the vaccinated mice remain tumor-free (depending on the cancer), but the vaccine reduced—and in some cases completely prevented—the cancer’s spread.”

Shingles vaccination is associated with a powerful reduction of the risk of dementia Shingles or herpes zoster (HZ) is a neurotropic virus that causes a painful and hard to treat illness. Evidence is accumulating that HZ vaccinations might lower the risk of dementia. This effect is su...

Shingles vaccination is associated with a powerful reduction of the risk of dementia edzardernst.com/2025/10/shin...

Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD Often labeled the brain’s fear center, the amygdala is much more complex than that. A study in Translational Psychiatry suggests that PTSD is linked to altered connectivity in one of its subregions, with potential implications for emotion and body awareness.

Neuroscientists are starting to unravel the amygdala’s complexity, shedding new light on PTSD

Kyle Buller & Joe Moore — Breathwork, Community, Creativity, and Fresh Psychedelic Research Joe and Kyle debrief a hometown Dreamshadow Transpersonal Breathwork weekend in Breckenridge, then sketch the next chapter for Psychedelics Today: a community-centric model (Navigators) that bundles e...

New episode: Joe & Kyle on breathwork, creativity myths, DMT & stroke findings, and our next chapter in community. Tune in: bit.ly/3It5N0v

Has anyone performed a tone-pain conditioning task, specifically using a laser, in mice? If so, please answer this question on #PainResearcher bit.ly/3UKLXAl #PRF bit.ly/3VjLLZ9

In this article, Court Wing writes about the transdiagnostic potential of psychedelics, including but not limited to, MDMA, LSD, DMT, and Ibogaine.

Learn more: maps.org/news/bulleti...

The only thing wrong with this editorial is that is too late.

Where was this disbelief from 2020-2024?

It’s been obvious for years that Makary snd Bhattacharya are bad faith actors.

The evidence is abundant and public.

sciencebasedmedicine.org/questions/

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

Called it on the couch at NYU…five years ago.

www.nature.com/articles/s41...

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

Some interesting little details in this new study. Particularly fascinating is the suggestion some therapeutic benefits from psilocybin emerge out of the complex interplay between both 5-HT2a and 5-HT1a receptors. It's not just one or the other.

China Rolls Out Its First Talent Visa as the US Retreats on H-1Bs The Chinese government unveiled a program to woo foreign talent just as the US cracked down on H-1Bs with a $100,000 fee. The move immediately provoked xenophobic backlash.

China started its own Visa to outcompete the US for talent since we recently tacked on a $100k fee. The plan they have could work but they are running into considerable domestic opposition. www.wired.com/story/china...

Cutbacks Force Long-COVID Clinic Closures: What Now? Funding cuts in the US and abroad have forced long-COVID clinic closures when treatment and new research are needed most. Now patients and doctors are scrambling.

Your thoughts on the future of Long COVID clinics?
www.medscape.com/viewarticle/...

Researchers increasingly seem to be moving data to EU platforms, primarily due to data privacy and surveillance concerns. I've also started to notice people who aren't in the tech world doing this too. Is anyone else observing this trend?