I also want to point out that four other groups have achieved strikingly similar results and conclusions (science is beautiful!). Have a look at their preprint www.biorxiv.org/content/10.6... to have an even more complete picture of what is going on with condensin II activation!
In this study we solved three cryo-EM structures and combined those snapshots with optical tweezers experiments @lumicks.bsky.social. We explain how the M18BP1 protein induces conformational changes in condensin II, making it competent for DNA binding and compaction.
Very happy to share a new preprint from the Vannini Lab @alessandrovannini.bsky.social at @humantechnopole.bsky.social. www.biorxiv.org/content/10.6...
If you are curious to understand what are the conformational changes that make condensin II able to compact the DNA during mitosis, have a read!
Extremely happy to see this out!
