Ove ร˜yรฅs ๐Ÿ‡บ๐Ÿ‡ฆ's Avatar

Ove ร˜yรฅs ๐Ÿ‡บ๐Ÿ‡ฆ

@oveoyas

Computational systems biologist integrating data with mathematical models to explain biology. ๐Ÿฆ ๐Ÿ„๐ŸŒฑ๐ŸŸ๐Ÿฎ๐Ÿง‘ Researcher at Oslo Center for Biostatistics and Epidemiology (OCBE).

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01.09.2023
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Latest posts by Ove ร˜yรฅs ๐Ÿ‡บ๐Ÿ‡ฆ @oveoyas

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Postdoctoral position in Machine Learning and Computational Biology (296798) | University of Oslo Job title: Postdoctoral position in Machine Learning and Computational Biology (296798), Employer: University of Oslo, Deadline: Friday, April 10, 2026

Open postdoctoral position (3-years) in Machine Learning and Computational Biology!

www.jobbnorge.no/en/available...

Job conditions are great ๐Ÿฅ๐Ÿ’ถ

The scientific environment is top-notch ๐Ÿงฌ

Oslo is a fantastic place to live โ›ท๏ธ๐Ÿ”๏ธ โ˜€๏ธ ๐ŸŒฒ

Please, get in touch if you have questions

09.03.2026 13:16 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from otherย Asgardarchaeota, in conditions that may have given rise to early eukaryotes.

Nature research paper: Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor

go.nature.com/4rSfRRw

23.02.2026 16:37 ๐Ÿ‘ 26 ๐Ÿ” 13 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Annotating genomes at increased scale and resolution Nature Reviews Genetics - In this Review, Ji et al. overview how rapidly advancing experimental and computational methods are enabling improved and automated annotation of gene structure and...

Our new review on genome annotation just appeared in @naturerevgenet.bsky.social, with a particular focus on the human genome, with Hayden Ji and Mihaela Pertea: rdcu.be/e4mI1

17.02.2026 12:46 ๐Ÿ‘ 24 ๐Ÿ” 12 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Happy to announce that CarveMe is now running online at usegalaxy.eu and usegalaxy.no ๐Ÿ™‚

16.02.2026 12:59 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Two Postdoctoral Researchers in Mathematical and Computational Oncology forย Personalized Breast Cancer Treatment We are seeking two ambitious Postdoctoral Researchers to join the Kรถhn-Luque group at the Oslo University Hospital. These 3-year positions are part of a high-impact project funded by the Norwegia...

We are hiring!

Seeking two ambitious postdoc to work at intersection of math modeling and machine learning for personalize breast cancer treatment.

2411.webcruiter.no/Main2/Recrui...

Great conditions, top-notc scientific environment and a fantastic place to live.

Please, get in touch for more

12.02.2026 23:38 ๐Ÿ‘ 3 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

They can hide, censor, and deny #climate change science but that doesn't change the #science.
They can try to repeal the #Endangerment Finding but that doesn't change the danger.
Reality will always win and history will never forget what they're doing and who is doing it.

12.02.2026 20:06 ๐Ÿ‘ 98 ๐Ÿ” 32 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 0
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Weโ€™re hiring: Research Group Leader in computational biology.

Are you generating more research ideas than you can explore? Lead cutting-edge AI & biology research at EMBL-EBI.

Apply by 11 April 2026: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

#ScienceCareers @ewaldlab.org @embl.org

10.02.2026 11:31 ๐Ÿ‘ 39 ๐Ÿ” 50 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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4-year PhD position in Biostatistics (292171) | University of Oslo Job title: 4-year PhD position in Biostatistics (292171), Employer: University of Oslo, Deadline: Thursday, February 12, 2026

Only a few days left to apply for this interesting PhD position in biostatistics at OCBE: www.jobbnorge.no/en/available...
@jmgran.bsky.social

09.02.2026 09:43 ๐Ÿ‘ 3 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Assembly of the infant gut microbiome and resistome are linked to bacterial strains in motherโ€™s milk - Nature Communications Here, with metagenomic analyses on longitudinal samples collected from 195 mother-infant pairs, the authors show that the breast milk microbiome contributes to infant gut assembly through bacterial st...

Breast milk isn't just nutrition โ€“ it delivers live bacterial strains that colonize the infant gut and persist for months.

Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:

doi.org/10.1038/s414...

18.01.2026 20:35 ๐Ÿ‘ 72 ๐Ÿ” 23 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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An Updated Bacterial and Archaeal Reference Genome Collection is Available! - NCBI Insights Download the updatedโ€ฏbacterial and archaeal reference genome collection! We built this collection of 22,307 genomes by selecting the โ€œbestโ€ genome assembly for each species among the 450,000+ prokaryo...

From #NCBI Insight | Updated Bacterial and Archaeal Reference Genome Collection is now available | #Bioinformatics #Genomics #OpenScience #OpenData ๐Ÿงฌ ๐Ÿ–ฅ๏ธ ๐Ÿงช
โฌ‡๏ธ
ncbiinsights.ncbi.nlm.nih.gov/2026/01/13/a...

13.01.2026 21:07 ๐Ÿ‘ 17 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Constructing a โ€œperiodic tableโ€ of bacteria to map diversity in trait space Abstract. Despite an ever-expanding number of bacterial taxa being discovered, many of these taxa remain uncharacterized with unknown traits and environmen

New paper up - inspired by the periodic table of the elements, we attempted to organize bacterial diversity in genome-inferred trait space academic.oup.com/ismej/advanc...

06.01.2026 19:31 ๐Ÿ‘ 54 ๐Ÿ” 21 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1

A database of over 15.000 strain design publications reveals a conserved set of metabolic engineering targets across microbial hosts and products https://www.biorxiv.org/content/10.64898/2025.12.15.694291v1

17.12.2025 07:02 ๐Ÿ‘ 6 ๐Ÿ” 7 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Gut micro-organisms associated with health, nutrition and dietary interventions - Nature Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the human gut microbiome and its association with diet and cardiometabolic conditions.

Nature research paper: Gut micro-organisms associated with health, nutrition and dietary interventions

go.nature.com/4oODWqv

12.12.2025 09:37 ๐Ÿ‘ 28 ๐Ÿ” 8 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Genome-scale metabolic modeling of Ruminiclostridium cellulolyticum: a microbial cell factory for valorization of lignocellulosic biomass | mSystems In this work, we present a manually curated genome-scale metabolic model for Ruminiclostridium cellulolyticum, one of the few species known to fully degrade cellulose and hemicellulose. The model was ...

Our new genome-scale model for R. cellulolyticum is out on mSystems:

journals.asm.org/doi/10.1128/...

Very proud of the hard work of my PhD student, Idun Burgos ๐Ÿ˜Š

30.09.2025 15:32 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Identification of dynamic models of microbial communities: A workflow addressing identifiability and modeling pitfalls Author summary Microbial communities, vital for human and environmental health, are complex systems whose quantitative behaviors are not yet fully understood. Scientists employ mathematical models to ...

journals.plos.org/ploscompbiol...

04.12.2025 11:58 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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The return of metabolism: biochemistry and physiology of glycolysis Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical princip....

onlinelibrary.wiley.com/doi/10.1111/...

04.12.2025 11:56 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Theย Microflora Danica atlas of Danish environmental microbiomes - Nature Microflora Danicaโ€”an atlas of Danish environmental microbiomesโ€”reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Microflora Danica: What can you learn from collecting and sequencing 10,000+ samples from a single country? Check out our new paper in @nature.com to find out. Incredible work led by Caitlin Singleton, Thomas B. N. Jensen, and Mads Albertsen from @aau.dk. ๐Ÿฆ ๐Ÿงซ๐Ÿงฌ
www.nature.com/articles/s41...

03.12.2025 20:50 ๐Ÿ‘ 68 ๐Ÿ” 31 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0โ€“2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...

"Our results enable us to reject mitochondrion-early scenarios of eukaryogenesis, instead supporting a complexified-archaean, late-mitochondrion sequence for the assembly of eukaryote characteristics"

www.nature.com/articles/s41...

03.12.2025 22:14 ๐Ÿ‘ 22 ๐Ÿ” 9 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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Dynamics of menopause from deconvolution of millions of lab tests Menopause reshapes female physiology, yet its full temporal footprint is obscured by uncertainty in the age of the final menstrual period (FMP). Here we analyse cross-sectional data on 300 million lab...

Revealing the dynamical time course of physiological changes before, during and after menopause. This revealed sudden changes at menopause in nearly all physiological systems. (2/2)
arxiv.org/abs/2511.05906

03.12.2025 08:09 ๐Ÿ‘ 17 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article) A quiet policy change means the government is making fewer bets on long-term science.

Gift link for NY Times article on cuts at NIH and NSF:
www.nytimes.com/interactive/...

02.12.2025 15:51 ๐Ÿ‘ 7 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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I am very excited to announce that a fully funded PhD position is available in my group.

Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia

Please RT or forward this information to interested candidates.

Deadline: 11.01.26

More info:

shorturl.at/f1TuF

27.11.2025 14:24 ๐Ÿ‘ 52 ๐Ÿ” 67 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2

Don't miss out on our free virtual symposium (Dec. 12th) focused on microbial metabolites and their effects on the host.

Sponsors: @amiposts.bsky.social, Pendulum, & Liv (@zymoresearch.bsky.social)

Registrants will receive free memberships to Applied Microbiology International.

Details below ๐Ÿ‘‡

18.11.2025 23:25 ๐Ÿ‘ 18 ๐Ÿ” 14 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ“ข Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social

15.11.2025 04:02 ๐Ÿ‘ 31 ๐Ÿ” 37 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
A table showing profit margins of major publishers. A snippet of text related to this table is below.

1. The four-fold drain
1.1 Money
Currently, academic publishing is dominated by profit-oriented, multinational companies for
whom scientific knowledge is a commodity to be sold back to the academic community who
created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis,
which collectively generated over US$7.1 billion in revenue from journal publishing in 2024
alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit
margins have always been over 30% in the last five years, and for the largest publisher
(Elsevier) always over 37%.
Against many comparators, across many sectors, scientific publishing is one of the most
consistently profitable industries (Table S1). These financial arrangements make a substantial
difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor &
Francis revenues were generated in North America, meaning that North American
researchers were charged over US$2.27 billion by just two for-profit publishers. The
Canadian research councils and the US National Science Foundation were allocated US$9.3
billion in that year.

A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year.

A figure detailing the drain on researcher time.

1. The four-fold drain

1.2 Time
The number of papers published each year is growing faster than the scientific workforce,
with the number of papers per researcher almost doubling between 1996 and 2022 (Figure
1A). This reflects the fact that publishersโ€™ commercial desire to publish (sell) more material
has aligned well with the competitive prestige culture in which publications help secure jobs,
grants, promotions, and awards. To the extent that this growth is driven by a pressure for
profit, rather than scholarly imperatives, it distorts the way researchers spend their time.
The publishing system depends on unpaid reviewer labour, estimated to be over 130 million
unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of
peer-review for decades, but the scale of the problem is now worse, with editors reporting
widespread difficulties recruiting reviewers. The growth in publications involves not only the
authorsโ€™ time, but that of academic editors and reviewers who are dealing with so many
review demands.
Even more seriously, the imperative to produce ever more articles reshapes the nature of
scientific inquiry. Evidence across multiple fields shows that more papers result in
โ€˜ossificationโ€™, not new ideas (10). It may seem paradoxical that more papers can slow
progress until one considers how it affects researchersโ€™ time. While rewards remain tied to
volume, prestige, and impact of publications, researchers will be nudged away from riskier,
local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with
limited progress whereas core scholarly practices โ€“ such as reading, reflecting and engaging
with othersโ€™ contributions โ€“ is de-prioritized. What looks like productivity often masks
intellectual exhaustion built on a demoralizing, narrowing scientific vision.

A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishersโ€™ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authorsโ€™ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in โ€˜ossificationโ€™, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchersโ€™ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices โ€“ such as reading, reflecting and engaging with othersโ€™ contributions โ€“ is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision.

A table of profit margins across industries. The section of text related to this table is below:

1. The four-fold drain
1.1 Money
Currently, academic publishing is dominated by profit-oriented, multinational companies for
whom scientific knowledge is a commodity to be sold back to the academic community who
created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis,
which collectively generated over US$7.1 billion in revenue from journal publishing in 2024
alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit
margins have always been over 30% in the last five years, and for the largest publisher
(Elsevier) always over 37%.
Against many comparators, across many sectors, scientific publishing is one of the most
consistently profitable industries (Table S1). These financial arrangements make a substantial
difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor &
Francis revenues were generated in North America, meaning that North American
researchers were charged over US$2.27 billion by just two for-profit publishers. The
Canadian research councils and the US National Science Foundation were allocated US$9.3
billion in that year.

A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year.

The costs of inaction are plain: wasted public funds, lost researcher time, compromised
scientific integrity and eroded public trust. Today, the system rewards commercial publishers
first, and science second. Without bold action from the funders we risk continuing to pour
resources into a system that prioritizes profit over the advancement of scientific knowledge.

The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a ๐Ÿงต 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...

11.11.2025 11:52 ๐Ÿ‘ 643 ๐Ÿ” 453 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 66
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Preprint site arXiv is banning computer-science reviews: hereโ€™s why The repository is taking steps to tackle a surge in low quality, AI-generated content.

You canโ€™t really blame arXiv for the decision to stop publishing computer science stuff (given the flood of slop) but this is also a textbook example of a global public good being gratuitously degraded www.nature.com/articles/d41...

07.11.2025 23:28 ๐Ÿ‘ 75 ๐Ÿ” 22 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 6
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Metalog: curated and harmonised contextual data for global metagenomics samples Abstract. Metagenomic sequencing enables the in-depth study of microbes and their functions in humans, animals, and the environment. While sequencing data

Great to see this finally published!

Metalog: curated and harmonised contextual data for global metagenomics samples

now out in @narjournal.bsky.social

academic.oup.com/nar/advance-...

31.10.2025 15:16 ๐Ÿ‘ 57 ๐Ÿ” 38 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2

Definitely a good use of AI!

15.10.2025 06:39 ๐Ÿ‘ 14 ๐Ÿ” 5 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Finally got my tool published!

09.10.2025 18:22 ๐Ÿ‘ 4 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Accelerated design of Escherichia coli reduced genomes using a whole-cell model and machine learning A machine learning model trained on whole-cell simulations predicts gene deletion effects on cell division. This approach enables rapid genome minimization and the design of a viable reduced E. coli g...

www.cell.com/cell-systems...

25.09.2025 08:31 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Very happy to introduce jsPCA, a fast and interpretable computational framework for spatial transcriptomics that simultaneously identifies spatial domains and variable genes across multi-slice and multi-sample data.

19.09.2025 06:49 ๐Ÿ‘ 17 ๐Ÿ” 8 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0