Andrew Maclean

A great collaboration of my group with @herassr.bsky.social and @heick.bsky.social groups searching for mammalian dsRNAs and their importance to human disease 🧬

UZH: Postdoc The newly founded Cryptosporidium lab at the Institute of Parasitology focuses on the genetic and transcriptomic basis of parasite virulence and persistence in Cryptosporidium and is committed to incl...

🚨 Postdoc position 🚨
I’m moving back to Switzerland this summer to launch my lab at the University of Zurich and am recruiting a Postdoctoral Fellow (start: late 2026).
Details & application:
jobs.uzh.ch/job-vacancie....

Please share! 😊

Want to computationally analyse a genome's-worth of protein localisations? Have data for 4.5 million cells at your fingertips using this Python tool to access TrypTag.org data www.biorxiv.org/content/10.6... (we're out of beta and releasing on time 🎂)

Very excited to share our work, a fish herpesvirus' cryo EM structure. It features a long PVAT tail, with new and host-like proteins discovered using modelAngelo, Dali, and Viro3D, including a host-like macrodomain
doi.org/10.64898/202...
@dbhella.bsky.social @grovearmada.bsky.social

Image of a herpesvirus structure

I am excited to share our latest preprint - An evolutionarily divergent herpesvirus with a giant tail. Featuring symmetry breaking and genome annotation from structure using ModelAngelo. doi.org/10.64898/202...

Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key #ubiquitin recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust #PlantImmunity👇🏾

Spatial Proteomics Workshop for Protists

(see more in thread below)

Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...

Congratulations to Barrack, we are very excited to welcome him here in Edinburgh.

Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University on FindAPhD.com PhD Project - Safeguarding the powerhouse: antibody-based characterisation of trypanosome mitochondrial quality control proteins at Lancaster University, listed on FindAPhD.com

🧬Fully Funded PhD
Mitochondria|Protein Homeostasis|Antibody Technologies
🤝In collaboration with @menzieslab.bsky.social and Nick Robinson
@blslancasteruni.bsky.social
🎓UK students only
⏰6th March 2026
📩Enquiries: c.dewar1@lancaster.ac.uk
www.findaphd.com/phds/project...
#phdopportunity #mitochondria

If you are a committed scientist who wishes to work with Toxoplasma or with organelles (or both!!) - come work with us:
www.jobs.gla.ac.uk/job/research...

Please share!
PhD position (4 years) available in my group @zmbp-tuebingen.bsky.social. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...

LAST CALL! Come join me at Glasgow University for evolutionary structural biology! We have fully positions.

Computational Postdoc:
www.jobs.gla.ac.uk/job/research...

Structural Postdoc:
www.jobs.gla.ac.uk/job/research...

Technician:
www.jobs.gla.ac.uk/job/technici...

FYI were starting weird structure/evolution/biology stuff at Glasgow University!

If you're interested let me know! Tell your friends!

CRYO www.jobs.gla.ac.uk/job/research...

BIOINFO www.jobs.gla.ac.uk/job/research...

TECHNICIAN www.jobs.gla.ac.uk/job/technici...

#science #hiring #evolution

We are actively recruiting a Post doc to work on the regulation of Toxoplasma différenciation. Please send a CV and cover letter if interested.
ciil.fr/teams/apicompl…

Double stranded RNA sensing is silenced during early embryonic development Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...

Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩

rdcu.be/eWMfA

I am pleased to share our latest preprint, detailing the characterisation of BDF7 in Leishmania. This non-canonical bromodomain factor is essential for the parasite to live inside the host macrophage and has a parasite specific function compared to the host ortholog , ATAD2. Details in the link:

A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...

Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...

Was a lot of fun working with @sheinerlab.bsky.social and Julius Lukes and his lab to explore the weird mitochondria of these under explored parasites. Thanks to all the authors.

A trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA Abstract. Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these

In the early 1980ies the labs of Cordingley, Boothroyd and Borst
discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events. academic.oup.com/nar/article/...

Save the date! The next instalment of Comparative Genomics of Unicellular Eukaryotes is a GO! Join us next year for a programme of talks, posters, ECR/networking activities.

Website and registration details to follow in the coming weeks.
See you October 5-10 2026 in beautiful San Feliu!!

Interested in parasitology? Looking to do a PhD? Cone join me and @geordieparasit.bsky.social in Edinburgh as we try and work out how human parasites get their vitamins.

Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...

CoccidiaUK 2025 A biannual gathering of parasitologists from across the UK to discuss all things coccidian!

There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's @crick.ac.uk (very central) & we're cooking up some fun swag :) www.eventbrite.co.uk/e/coccidiauk...

Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...

Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages?
Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh: www.findaphd.com/phds/project...

Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...

Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.

Join us at 12 noon on Thursday 14th November!

Register at docs.google.com/forms/d/e/1F...

Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com

If you’re interested in solving bacterial mysteries, this PhD project is for you!

www.findaphd.com/phds/project...

Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...

Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in
@PLOSPathogens
journals.plos.org/plospathogen...

Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.

Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️

A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria