Neuropsychopharmacology

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats Neuropsychopharmacology - Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation...

In ♂️🐀 pre-surgical stress exacerbated & prolonged somatosensory hypersensitivity, pain-related aversion & anxiety via enhanced spinal microglial NLRP3–interleukin-1β signaling, with effects mediated by β-adrenergic receptor activation

Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis Neuropsychopharmacology - Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based...

Using MVPA of resting-state fMRI identify 🧠 features to distinguish MDD patients with versus without a history of suicide attempts, findings implicate disrupted sensory–cognitive integration as a link from trauma to suicide risk in MDD

Modulation of hierarchical motor sequence learning by alpha-synuclein and the adenosine A2A receptor Neuropsychopharmacology - Modulation of hierarchical motor sequence learning by alpha-synuclein and the adenosine A2A receptor

This study explored how alpha-synuclein aggregation in the SNc disrupts executive function in Parkinson’s disease using a hierarchical motor sequence learning paradigm, finding adenosine A2A receptors as a promising therapeutic target 💊

That's all for this for #TWiNPP - see you the same time, same place, next week (and every week after)

Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine Neuropsychopharmacology - Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine

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A review from Lenze et al., focuses on an evidence-informed stepwise algorithm for approaching precision pharmacotherapy for late-life depression (LLD) 💊

Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice Neuropsychopharmacology - Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice

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Gyles et al. use a 🐭 model of treatment-resistant MDD (TRD) & RNA sequencing to reveal transcriptional signatures associated with antidepressant treatment / Angélica Torres-Berrío, PhD @sinaibrain.bsky.social Eric Nestler Eric Parise

Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial Neuropsychopharmacology - Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial

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From Jin et al., an individualized task-guided accelerated continuous theta burst stimulation strategy targeting the right dorsolateral prefrontal cortex shows efficacy in alleviating depressive and anxiety symptoms while improving social dysfunction in MDD 🧠

We're back with another run down of what's new #ThisWeekInNPP

See below for the latest on continuous theta burst stimulation, transcriptional signatures from a mouse model of TRD, and a precision pharmacotherapy for late-life depression 👇

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Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression Neuropsychopharmacology - Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression

In this review, the authors examine factors contributing to depressive episode recurrence following remission in late-life depression, integrating evidence across cognitive, behavioral, social, environmental, and neuroimaging domains 🧠

From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation Neuropsychopharmacology - From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation

Do resting-state dynamics network predict task-evoked 🧠 responses under pharmacological modulation?

Findings suggest intrinsic network dynamics influence drug-specific modulation of cognitive control & may support individualized txt

Central amygdalar PKCδ neurons mediate fentanyl withdrawal Neuropsychopharmacology - Central amygdalar PKCδ neurons mediate fentanyl withdrawal

Circuit mapping of PKCdelta–expressing neurons in the lateral capsule of the CeA identified opioid-sensitive inputs, implicating central amygdala protein kinase C-delta neurons as key mediators of the somatic features of opioid withdrawal

In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain Neuropsychopharmacology - In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain

This study examined mGluR5 availability in individuals with & without chronic pain across psychiatric diagnoses; ⬇️ availability was associated with ⬆️ depression, anxiety, & executive dysfunction, highlighting mGluR5 as a potential treatment target

Thanks for the shoutout! We're very excited to share this review!

And that's a wrap for this week!

Join us next Tuesday for the next installment of This Week in NPP #TWiNPP

The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner Neuropsychopharmacology - The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner

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Castell et al. demonstrate that the sodium leak channel NALCN in dopamine D2 receptor-expressing striatal neurons modulates response to anti-dopaminergic treatments in a sex-specific manner

Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity Neuropsychopharmacology - Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity

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From Kuang et al., a machine learning study that suggests that stress-related neurotoxicity may contribute to cognitive decline in PTSD / Anthony Chesebro

Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway Neuropsychopharmacology - Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway

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Ascone et al. show that psilocybin microdosing rescues recognition memory deficits, potentially via neurotrophic signaling, in a mouse 🐀 model of Fragile X Syndrome

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Olu Ajilore, MD, PhD and Dr. Reynolds underscore key contributors to heterogeneity in later life and highlight importance of computational psychiatry and implementation science for developing tractable real-world solutions

Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity Neuropsychopharmacology - Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity

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Tan et al. show that adaptive harm avoidance is dependent on a time-sensitive window of GABA-mediated inhibition of VTA dopamine neurons during punishment learning

Sex-dependent developmental changes in behavior, brain structure, functional connectivity, and sensory perception following exposure to psilocybin during adolescence Neuropsychopharmacology - Sex-dependent developmental changes in behavior, brain structure, functional connectivity, and sensory perception following exposure to psilocybin during adolescence

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From Sahoo et al., exposure to psilocybin during adolescence induces long-term changes in the brain and behavior in a sex-specific manner

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The Olympics are over, but #TWiNPP never ends! 🥇

See below for the newest articles published in NPP (they all get medals in our books!) 👇

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles Neuropsychopharmacology - Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles

Be sure to check out Dr. Trainor's recent NPP paper, which inspired this episode ⤵️

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles NPP BrainPod · Episode

Oxytocin is perceived to have anti-anxiety & affiliative effects - that’s why many are excited about it as a potential therapeutic💊

Our latest BrainPod episode features Dr. Brian Trainor, whose lab has been exploring oxytocin for the past decade 🎙️

Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area Neuropsychopharmacology - Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area

This study investigates how stress modulates nociceptin/orphanin FQ signaling within midbrain reward circuitry, identifying a potential mechanistic link between stress and motivation relevant to anxiety and depression

In this comment, the authors argue that impaired brain energetics, characterized by a shift from oxidative phosphorylation to glycolysis, is a shared feature of neuropsychiatric disorders and a promising therapeutic target

Differential neural responses to rhythmic and patterned TMS protocols: Insights from EEG spectral analysis Neuropsychopharmacology - Differential neural responses to rhythmic and patterned TMS protocols: Insights from EEG spectral analysis

This study used TMS–EEG in patients with major depressive disorder to compare network effects of rhythmic and patterned repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex

The positive allosteric modulator GNE-9278 increases gating, conductance, and Ca2+ permeability for GluN2D-containing NMDA receptors Neuropsychopharmacology - The positive allosteric modulator GNE-9278 increases gating, conductance, and Ca2+ permeability for GluN2D-containing NMDA receptors

This study examined the mechanism of action of the NMDA receptor positive allosteric modulator GNE-9278 and its subtype-specific effects

a woman holding a guitar and making a heart with her hands ALT: a woman holding a guitar and making a heart with her hands

Check back in next week for another weekly roundup of #TWiNPP!

Hair cortisol concentrations as a putative biomarker for suicidal behavior - Neuropsychopharmacology Neuropsychopharmacology - Hair cortisol concentrations as a putative biomarker for suicidal behavior

Finally, Taraban et al. show that hair cortisol concentrations may be an objective biomarker of suicide in high-risk adults @NadineMMelhem

www.nature.com/articles/s41...