Vanesa Fernández-Moreira

Structure–activity insights into benzimidazole-based Ir(III) cyclometallated complexes for cancer therapy A family of cyclometallated Ir(iii) complexes incorporating benzimidazole-based C^N ligands and ancillary diimines with distinct functionalities, 2-(pyridin-2-yl)-1H-benzo[d]imidazole (L1), 4-(1H-benz...

Tremendously happy to finally see this work published! A wonderful collaboration with colleagues from the University of Vigo. Very proud of the team and the journey behind this study. pubs.rsc.org/en/content/a...

After an outstanding PhD defence by @antoniolinero.bsky.social. we’re enjoying the best of Murcia with @joseruizlab.bsky.social , @giampaolobarone.bsky.social and @kargesgroup.bsky.social! Proud moment.

A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction A novel Os(II)-Pt(IV)-Ceritinib (Os-Pt-Cer) conjugate enables triple-action anticancer therapy by integrating photodynamic therapy, chemotherapy, and immunogenic cell death (ICD) induction into a sin...

Thrilled to share that I’m a co-author of a new article recently published in Angewandte Chemie!
Huge thanks to @gassergroup.bsky.social , @martard.bsky.social , and Dan Gibson for the collaboration, support, and all the learning along the way. 🌟
#Research #Science

doi.org/10.1002/anie...

Very glad to share our new paper in @chemicalscience.rsc.org on in cellulo catalysis using our cyclodextrins, in collaboration with @gassergroup.bsky.social and @cariouk.bsky.social team and with Sylvain Roland, Hugo Madec and Yanis Tigherghar
pubs.rsc.org/en/content/a...

🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...

Goodbye @martard.bsky.social! Many thanks for your hard work! We wish you all the very best for the start of your independent career in Zaragoza!
@chimieparistechpsl.bsky.social

Second stop at ISQCH in Zaragoza. Had a fantastic day making new friends and discovering a very exciting department with lots of cool chemistry.

Very happy to welcome two exchange PhD students: Eva Morales-Pioz from the group of @vanesafm-isqch.bsky.social and Guglielmo Spinelli from @nanobic.bsky.social. Enjoy your stays at @chimieparistechpsl.bsky.social
@cariouk.bsky.social

Our chairs @albrecht-lab.bsky.social and @evaheviagroup.bsky.social are excited to welcome you to Bern and the opening #eucomc2025

A Homobimetallic Frustrated Lewis Pair Cobalt Catalyst for the Methanolysis of Hydrosilanes The bimetallic Co(I)/Co(–I) complex [Co(CO)2(κ3-P,N,P-PNHP)][Co(CO)4] (1) has shown excellent activities in the methanolysis of hydrosilanes, surpassing the related bimetallic Co(I)/Co(–I) complex [C...

Happy to share our Accepted Article in Angewandte Chemie
onlinelibrary.wiley.com/doi/10.1002/...

📸 A great moment at #LUCESCOSTAction in Zadar!
We gathered for the official group photo during the coffee break — celebrating collaboration, science, and new connections! 🌟🤝 @costprogramme.bsky.social

Nice to see our recent article on the Front cover- now published in Inorganic Chemistry Frontiers. doi.org/10.1039/D4QI.... Great collaboration with @MarchanLab_UB.

Molecular Design Principles for Photoactive Transition Metal Complexes: A Guide for “Photo-Motivated” Chemists Luminescence and photochemistry involve electronically excited states that are inherently unstable and therefore spontaneously decay to electronic ground states, in most cases by nonradiative energy release that generates heat. This energy dissipation can occur on a time scale of 100 fs (∼10–13 s) and usually needs to be slowed down to at least the nanosecond (∼10–9 s) time scale for luminescence and intermolecular photochemistry to occur. This is a challenging task with many different factors to consider. An alternative emerging strategy is to target dissociative excited states that lead to metal–ligand bond homolysis on the subnanosecond time scale to access synthetically useful radicals. Based on a thorough review at the most recent advances in the field, this article aims to provide a concise guide to obtaining luminescent and photochemically useful coordination compounds with d-block elements. We hope to encourage “photo-motivated” chemists who have been reluctant to apply their synthetic and other knowledge to photophysics and photochemistry, and we intend to stimulate new approaches to the synthetic control of excited state behavior.

A simple guide to the design of metal complexes in luminescence and photoredox catalysis.

With Giacomo Morselli and Christian Reber in JACS @jacs.acspublications.org

pubs.acs.org/doi/10.1021/...

Exciting news! 🌟@BioCuidadReal25 will take place from June 2-4! Join us for an incredible conference on #BioinorganicChemistry featuring amazing plenary speakers! Christelle Hureau, @iottgroup.bsky.social, Ramon vilar and Petra Heffeter

In situ generated cobalt(I) catalyst for the efficient synthesis of novel pyridines: revisiting the mechanism of [2 + 2 + 2] cycloadditions The [2 + 2 + 2] cycloaddition of alkynes and nitriles is an efficient and atom-economic method for the synthesis of pyridines. However, most of the examples so far reported entail the use of diynes, w...

Happy to share our new work cobalt-catalyzed [2 + 2 + 2] cycloadditions
pubs.rsc.org/en/content/a...

A novel benzothiazole-1,2,3-triazole-based arene osmium(II) complex as an effective rhabdomyosarcoma cancer stem cell agent We designed a series of pseudo-octahedral arene Os(ii) complexes (Os1–Os5) with the general formula [(η6-p-cym)Os(BTAT)Cl]+, where BTAT represents chelating N^N′ ligands based on the 1-aryl-4-benzothi...

A novel arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent - now published in InorgChemFront in collaboration with Viktor Brabec pubs.rsc.org/en/content/a... Congrats to all the co-authors.

Come join us for our biannual meeting in Ciudad Real!

More info here:
www.biociudadreal.es

The Jonathan L. Sessler Fellowship for Emerging Leaders in Bioinorganic and Medicinal Inorganic Chemistry - American Chemical Society American Chemical Society: Chemistry for Life.

📣 Attention #chemsky:
Nominate an emerging leader in Bioinorganic and Medicinal Inorganic Chemistry for the Jonathan L. Sessler Fellowship
📅 Deadline: January 31
All info: www.acs.org/funding/scho...

Please tell all your colleagues on and off 🦋

🌟 Starting the year with exciting news! Our Frontier paper is now out in @daltontrans.bsky.social
💡Breaking the deep-red light absorption barrier of iridium(iii)-based PSs.
👉🏻https://pubs.rsc.org/en/content/articlelanding/2025/dt/d4dt03014a
@joseruizlab.bsky.social @gassergroup.bsky.social

Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Ren, Gao, and co-workers @InorgChem #iridium #Ir2 #PDT #PTT #ROS #IR

Super excited to launch with @albrecht-lab.bsky.social the #bluesky account #EUCOMC2025 @eucomc2025.bsky.social
Come to #Bern in July 6-10 2025 for a feast of #organometallic #chemistry and to discover one of the nicest cities in the world🇨🇭! #SCS #EuChemS Follow the account for further details!

Check out our article in Dalton Trans. about a Necrosis Inducing Tetranuclear Ru(II)-Re(I) complex for Anticancer Therapy. Congrats to Julia, Eleni, Stephan, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D4DT...

Merry Christmas and Happy New Year 2025! Our best wishes for all of you!

Check out our article in J. Med. Chem. @acsmedi.bsky.social about the Combinatorial Synthesis toward the Discovery of Highly Cytotoxic Fe(III) Complexes. Congrats to Felix, Lisa, Zisis, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de pubs.acs.org/doi/10.1021/...

Congrats Pepe and coworkers!!!

A Novel Substituted Benzo[g]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent Herein, we describe and investigate biological activity of three octahedral ruthenium(II) complexes of the type [Ru(C∧N)(phen)2]+, RuL1–RuL3, containing a π-expansive cyclometalating substituted benzo[g]quinoxaline ligand (C∧N ligand) (phen = 1,10-phenanthroline). Compounds RuL1–RuL3 in cervical, melanoma, and colon human cancer cells exhibit high phototoxicity after irradiation with light (particularly blue), with the phototoxicity index reaching 100 for the complex RuL2 in most sensitive HCT116 cells. RuL2 accumulates in the cellular membranes. If irradiated, it induces lipid peroxidation, likely connected with photoinduced ROS generation. Oxidative damage to the fatty acids leads to the attenuation of the membranes, the activation of caspase 3, and the triggering of the apoptotic pathway, thus implementing membrane-localized photodynamic therapy. RuL2 is the first photoactive ruthenium-based complex capable of killing the hardly treatable colon cancer stem cells, a highly resilient subpopulation within a heterogeneous tumor mass, responsible for tumor recurrence and the metastatic progression of cancer.

Glad to share our recent paper in collaboration with Prof. Brabec, published in JMC. Congrats to all co-authors!
pubs.acs.org/doi/full/10....

Check out our paper in J. Biol. Inorg. Chem. @springer1842.bsky.social about the shift of cell death mechanism in primary human neutrophils upon treatment with a Ru(II) polypyridine complex. Great collaboration with the Kruss Group! Congrats Nicolas and Jennifer! dx.doi.org/10.1007/s007...

Mitochondria Localized Anticancer Iridium(III) Prodrugs for Targeted Delivery of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors and Cytotoxic Iridium(III) Complex | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Venkatesh & co-workers @InorgChem #iridium #mitochondria #Mcl_1 #esterase

Congrats Benoît!!! 🥂

Excellent talk from Ana Belén Caballero at the ISQCH in Zaragoza, sharing her results in controlling amyloil aggregation. It was a pleasure listen to new metal-based approaches in medicine! @unizar.es @csic.es