Christian Münch

🎉 In the final round of the ExStra Program of the DFG, the CPI has been selected & is honored with funding for another 7 years! 🏆 With the vision that “precision biology drives precision medicine”, funds will be used for high-risk, innovative research for cardiopulmonary health ❤️🫁!

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster!
A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de
#ClustersOfExcellence #SCALEcluster 🧵

🗺️ Interactive Map Update!

The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉

Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com

#ProteinDegradation

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

Congratulations!!!

G-quadruplexes and their unexpected ability to fold proteins | PNAS G-quadruplexes and their unexpected ability to fold proteins

Have a look at our newest commentary in @pnas.org :

"G-quadruplexes and their unexpected ability to fold proteins"

Full text: www.pnas.org/doi/10.1073/...

#G4 #quadruplex #proteins #folding

Fantastic work and important inside into a longstanding question!

Rupert Beale @bealelab.bsky.social and co-workers @crick.ac.uk @imperialcollegeldn.bsky.social show that #caspase cleavage of #influenza A #virus M2 disrupts M2-LC3 interaction and regulates virion production.

-> www.embopress.org/doi/full/10....

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658 Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Life Sciences Bridge Award – the award for talented researchers in #lifeSciences: the Aventis Foundation Life Sciences Bridge Awards are endowed with a subsidy amount of 100,000 each. Guidelines and application at bridge.aventis-foundation.org
Deadline: 30 April 2025

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....

Just one week left to apply!

Compositionally unique mitochondria in filopodia support cellular migration Marlar-Pavey et al. determine that a subpopulation of compositionally unique mitochondria, METEORs, dynamically localize to filopodia. Loss of mitochondrial targeting to filopodia correlates with a re...

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social!

www.cell.com/current-biol...

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
www.science.org/doi/10.1126/...

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Ribosomes cooperate through transient collisions to ensure efficient translation.

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

www.cell.com/cell/fulltex...

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!

Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...

We are on the home stretch! 🏁

Only 1.5 weeks left to #apply for our #gradschool!

Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!

👉 imprs-cbp.mpg.de/call-for-app...

#imprs_cbp #imprs2impress #science

Assistant Professor in Biophysics

#Jobs We are looking for a new colleague! Tenure Track Assistant Professor in Biophysics in the domains of functional imaging and biophysics. More info here: www.wur.nl/en/vacancy/a...

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Home International Max Planck Research School on Subcellular Architecture and Dynamics

imprs-cbp.mpg.de

Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs

Wrapped up our first Symposium on Advances in Therapeutic Approaches! 🎉 Huge thanks to all the inspiring speakers and extra kudos to our very own @thatmassspecguy.bsky.social for unveiling our innovative #proteomics methods to profile E3 ligase & #PROTAC targets. 🔬✨
#TheraNova, #ENABLE, #Proxidrugs

What a great joy to meet up with the PROGENIE group to discuss the future of #proteostasis and all the topics of new and not-anymore-so-new PIs.

Join us next time if you are a new PI in Europe working on proteostasis, 👉https://molsysmed.de/project/proteostasis-group-of-european-new-investigators

Thank you Ville

Thank you Arun

Thank you Leo

Thank you Guille

Thank you André

Thank you Julien