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Artemy Kolchinsky

@artemyte

Researcher studying nonequilibrium thermodynamics, information theory, origin of life, complexity. Currently at Universitat Pompeu Fabra in Barcelona, Spain

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27.10.2024
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Latest posts by Artemy Kolchinsky @artemyte

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In 1874, Georg Cantor published one of the most important papers in math’s 4,000-year history. The ideas in it were stolen. 🧡

25.02.2026 16:33 πŸ‘ 29 πŸ” 11 πŸ’¬ 4 πŸ“Œ 2
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Evolution of error correction through a need for speed Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

Fascinating paper β€” molecular error correction might not incur an accuracy/speed tradeoff. In fact, it may be favored by evolution simply due to increased speed
www.science.org/doi/10.1126/...

23.02.2026 08:56 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
The shape at left is angular, while the shape at right has rounded bulges.  This picture is used as a test to demonstrate that people may not attach sounds to shapes arbitrarily. 

From here:

https://commons.wikimedia.org/wiki/File:Booba-Kiki.svg

The shape at left is angular, while the shape at right has rounded bulges. This picture is used as a test to demonstrate that people may not attach sounds to shapes arbitrarily. From here: https://commons.wikimedia.org/wiki/File:Booba-Kiki.svg

Which of these shapes looks like the sound "bouba", and which looks like the sound "kiki"?

People of all cultures agree on this, and now it's been found that baby chicks do too:

phys.org/news/2026-02...

It's called the bouba/kiki effect, and I think it follows from physics!

(1/2)

22.02.2026 21:26 πŸ‘ 14 πŸ” 3 πŸ’¬ 2 πŸ“Œ 1
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Our paper w/ @maguilera.net & Sosuke Ito is out in PRL. We combine ideas from stochastic thermodynamics & nonequilibrium Maximum Entropy to quantify forces + dissipation in high-dimensional nonequilibrium systems, including spin glasses and neural data

link: journals.aps.org/prl/abstract...

19.02.2026 12:08 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Joe Halpern passed away Friday at the age of 72. He was a leader in mathematically reasoning about knowledge.

www.linkedin.com/pos...

16.02.2026 07:34 πŸ‘ 8 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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β˜€οΈ 2026 Summer School in the Pyrenees - Unifying Mathematical Models of Biodiversity
Applications are now open!
This school offers a state-of-the-art overview for interdisciplinary theoreticians.
πŸ—“οΈ July 5-11
🎯 PhD students to senior researchers
ℹ️ intp.science/en/summer26....
πŸ“­ contact@intp.science
🌐πŸ§ͺ

28.01.2026 10:39 πŸ‘ 18 πŸ” 10 πŸ’¬ 0 πŸ“Œ 1
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Can we engineer cognition in aneural systems? What are the challenges and implications? Can synthetic biology be used to interrogate basal cognition? Our new paper with @jordiplam.bsky.social explores these questions using models of minimal gene circuits. Available here pubs.acs.org/doi/pdf/10.1...

10.02.2026 21:50 πŸ‘ 27 πŸ” 6 πŸ’¬ 1 πŸ“Œ 1
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Point of no returns: researchers are crossing a threshold in the fight for funding With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

"In other words, European taxpayers will have spent more on the funding process than on the funding itself, and the scientific ecosystem has been drained"

The situation is rapidly becoming unsustainable: the current research funding scheme does not work.

www.nature.com/articles/d41...

28.01.2026 12:59 πŸ‘ 15 πŸ” 9 πŸ’¬ 2 πŸ“Œ 0

A remarkable preprint that shows emergence of active protocells from simple starting conditions

26.01.2026 21:07 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

If you work on the origins of life / prebiotic chemistry, consider joining OoLEN 🧬🌍

We’re an early-career community for connecting across disciplines, sharing opportunities, and building momentum together.

Join: oolen.org/join
(And feel free to reply with what you work on!)
#OriginOfLife

12.01.2026 08:00 πŸ‘ 11 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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Launch of new Canada Impact+ Research Training Awards As announced in Budget 2025 -

Interested in the intersection of nonequilibrium thermodynamics and biophysics? Think Canada might be a nice place for your PhD/postdoc? Talk to me! Brand-new funding opportunity has quick deadline (so likely undersubscribed). nserc-crsng.canada.ca/en/news/laun...
SFU internal deadline Feb 11

06.01.2026 14:04 πŸ‘ 6 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Nucleation - Wikipedia

Yes, its possible to have local maxima of entropy. Supercooled water is one example, as are other phase transitions that require a "nucleation" event. en.wikipedia.org/wiki/Nucleat...

06.01.2026 16:39 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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"Choosing problems is the primary determinant of what one accomplishes in science."
'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists.
pni.princeton.edu/document/1136

05.01.2026 15:09 πŸ‘ 37 πŸ” 11 πŸ’¬ 0 πŸ“Œ 1
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Thermodynamic Geometric Constraint on the Spectrum of Markov Rate Matrices A thermodynamic constraint is placed on the spectrum of Markov rate matrices, allowing for a better understanding of the dynamics of biochemical clocks.

New paper in PRL on the relationship between thermodynamic driving and eigenvalues in Markovian master equations. We prove a weaker version of a beautiful conjecture proposed by Uhl and Seifert. Led by Guo-Hua Xu, with Jean-Charles Delvenne and Sosuke Ito
journals.aps.org/prl/abstract...

20.12.2025 02:08 πŸ‘ 12 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Cooperation is a universal feature of complex systems, from the origins of life and microbiomes to societies. What universal patterns can be found in these systems? Here's our new @pnas.org paper. @jordipinero.bsky.social @artemyte.bsky.social @sfiscience.bsky.social www.pnas.org/doi/epdf/10....

19.12.2025 18:44 πŸ‘ 75 πŸ” 30 πŸ’¬ 4 πŸ“Œ 2
When SchrΓΆdinger Reinvented the Wheel Erwin SchrΓΆdinger’s β€œWhat is Life?” is perhaps one of the most influential works in theoretical biology, but what if I told you that one of the key ideas discussed in it was nothing new?

The characterization of life as a thermodynamic phenomenon out of equilibrium is usually attributed to SchrΓΆdinger.

What if I told you that he wasn't the first (not even the secondπŸ˜Άβ€πŸŒ«οΈ) to reach that famous and influential conclusion?/1

#complexitycatπŸˆβ€β¬›

amahury.github.io/posts/reinve...

17.10.2025 13:35 πŸ‘ 18 πŸ” 6 πŸ’¬ 2 πŸ“Œ 4
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936

It's part of a great special issue on fundamental constraints on the origins of life, organized by
@ricardsole.bsky.social and Chris Kempes royalsocietypublishing.org/toc/rstb/202...

07.10.2025 13:10 πŸ‘ 12 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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After a long time in the making, my paper on nonequilibrium thermodynamics of Darwinian evolution has been published in Philosophical Transactions B. Updated version: arxiv.org/abs/2112.02809

07.10.2025 09:33 πŸ‘ 60 πŸ” 17 πŸ’¬ 3 πŸ“Œ 2
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Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936

How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social

02.10.2025 09:04 πŸ‘ 73 πŸ” 31 πŸ’¬ 1 πŸ“Œ 0

Possible biosignatures detected on Mars
www.nature.com/articles/d41...

15.09.2025 21:19 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Modern aspects of Markov chains: entropy, curvature and the cutoff phenomenon The cutoff phenomenon is an abrupt transition from out of equilibrium to equilibrium undergone by certain Markov processes in the limit where the size of the state space tends to infinity: instead of ...

Reading this beautiful review of the "cutoff timescale" in Markov chains, the timescale over which a system relaxes from nonequilibrium to equilibrium behavior arxiv.org/abs/2508.21055

15.09.2025 20:54 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Center for the Alignment of AI Alignment Centers We align the aligners

This new center strikes the right tone in approaching the AI alignment problem. alignmentalignment.ai

11.09.2025 20:47 πŸ‘ 59 πŸ” 14 πŸ’¬ 4 πŸ“Œ 4
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Can a single cell learn? Even without a brain, some microbes show simple forms of cognition. Can this basal cognition be engineered? Check our new paper with @jordiplam.bsky.social on the minimal synthetic circuits & their cognitive limits. @drmichaellevin.bsky.social www.biorxiv.org/content/10.1...

10.09.2025 11:48 πŸ‘ 110 πŸ” 42 πŸ’¬ 4 πŸ“Œ 6
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Kyoto Workshop on Quantum Thermodynamics and Stochastic Thermodynamics 2025 Schedule and VenueDecember 8-12, 2025Β Panasonic Auditorium, Yukawa Hall, YITP, Kyoto University, JapanScopeRecent advances in physics have increasingly highlighted the need to understand energy conver...

Helping to organize this workshop on quantum and stochastic thermodynamics in Kyoto, Japan, Dec 8-12. Resource theory, optimal transport, and more. Submissions open!

indico.yukawa.kyoto-u.ac.jp/event/68/

05.09.2025 00:43 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Physics of Life: Exploring Information as a Distinctive Feature of Living Systems Living systems are defined by their active acquisition and use of information. This Roadmap surveys current research on life's information processes and their importance for the search for life beyond...

Here is our new paper that we're really excited about. What makes a cell different from a rock? The answer we argue is the USE of information. But information carries meaning and that changes everything if we want to understand the "physics of life".

journals.aps.org/prxlife/abst...

04.09.2025 11:38 πŸ‘ 12 πŸ” 7 πŸ’¬ 4 πŸ“Œ 1
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Proud of this preprint with my friends Jonathan Bauermann and @artemyte.bsky.social, about chemical oscillators & phase separation! Main findings:
1. Phase separation controls frequency and amplitude of oscillations
2. If reactions are fast, spirals of droplets emerge!

arxiv.org/abs/2507.16030

01.08.2025 08:13 πŸ‘ 15 πŸ” 4 πŸ’¬ 5 πŸ“Œ 1
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How can we build a general theory of mutualistic communities? After five years, we finally completed a new Neutral Theory of Cooperation that is fully solved analytically and displays remarkable properties @jordipinero.bsky.social @artemyte.bsky.social @manlius.bsky.social arxiv.org/abs/2506.09737

12.06.2025 20:16 πŸ‘ 68 πŸ” 26 πŸ’¬ 2 πŸ“Œ 0
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We have a new preprint about measuring entropy production in high-dimensional systems, using ideas from information geometry. We successfully infer EP from brain recordings and spin models containing 1000+ degrees of freedom. With
@maguilera.net and Sosuke Ito arxiv.org/abs/2505.10444

10.06.2025 14:29 πŸ‘ 11 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore key ideas from evolutionary theory and are seriously flawed. Check this paper in PNAS www.pnas.org/doi/abs/10.1...

31.05.2025 15:55 πŸ‘ 74 πŸ” 27 πŸ’¬ 3 πŸ“Œ 3