Jingxun Chen

📣 103 participants and counting…
The 2025 Nothobranchius Symposium is fast approaching!
🧬 Join us in beautiful Jena, Germany, June 5–6, 2025, for cutting-edge talks on #killifish.
📝 Abstracts accepted until April 22
🔗 notho-2025.de
We look forward to meeting you at #Notho25!

Oligomeric RNA cryoEM structures revealed by Zhaoming Su and colleagues @science.org. Structural motifs that contribute to RNA multivalency: kissing loop, palindromic base-pairing, A-stacking, metal coordination, pseudoknot, minor-groove. First glimpse into molecular interactions of RNA multivalency

Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏

www.science.org/doi/10.1126/...

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Ribosomes cooperate through transient collisions to ensure efficient translation.

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

www.cell.com/cell/fulltex...

Global organelle profiling reveals subcellular localization and remodeling at proteome scale Organelle proteomics defines the cellular landscape of protein localization and highlights the role of subcellular remodeling in driving responses to perturbations such as viral infections.

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

www.cell.com/cell/fulltex...

✨✨The 2025 Keystone Symposium on Aging and Gerotherapeutics is coming up and early bird registration ends today! Very excited about our speaker lineup. Check it out!
www.keystonesymposia.org/conferences/...

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

Following the footsteps of the best :) Many thanks!

Would you mind adding me, too? Thank you so much!

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵