Love it, thanks Joseph!
23.12.2025 03:44
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Love it, thanks Joseph!
#IDsky
Interested in thoughts on any of these trials as well as suggestions for other literature to include. @uwidfellowship.bsky.social @pergamic.bsky.social @rupalij.bsky.social
Want the full reading list?
See “Essential Publications in Infectious Diseases 2025” link below, with more details on essential literature from this year:
pdf: app.box.com/s/ny7m9d0pdi...
Ppt on request
Thanks for reading and for everything you do.
8️⃣ Big Picture Takeaways
📌 Guidelines often rest on limited evidence
📌 Treatment durations keep shrinking—even for TB
📌 PO often >> IV. Safe and patient centered.
📌 RSV prevention is a true breakthrough
📌 Despite setbacks, this is still an exciting time to be in ID 👇
7️⃣ Vaccines: A Standout Year
RSV vaccines: ~80–90% reduction in RSV hospitalizations in adults ≥60
mRNA flu vaccines: superior efficacy vs standard flu shots, with more reactogenicity
Emerging data suggest mRNA vaccines may synergize with cancer immunotherapy
Woot woot! 👇
6️⃣ COVID Therapeutics: Reappraisal
Large real-world data suggest Paxlovid offers little benefit in highly vaccinated older adults.
Its role in 2025 is increasingly narrow and should be framed honestly. 👇
5️⃣ Antimicrobials: Find the niche
Cefiderocol: noninferior, not superior; reserve for salvage
Olorofim: bright spot in mold infections. Rare mold trials are hard!
Dalbavancin: viable consolidation therapy after S. aureus bacteremia clearance
Gepotidacin is here! 👇
4️⃣ Mpox: A Hard Lesson in Evidence
Randomized trials now show no clinical benefit of tecovirimat for mpox.
Animal models and uncontrolled observational data may have misled us—an important cautionary tale for outbreak therapeutics. 👇
3️⃣ STIs: Paradigm Shifts
Two practice-changing NEJM trials:
Male partner treatment for bacterial vaginosis cut recurrence nearly in half
Twice-yearly lenacapavir for HIV PrEP showed ~90% protection
Implementation, cost, and access will determine real-world impact. 👇
2️⃣ Vector Control: Entomology ≠ Outcomes
Three trials, three lessons:
Ivermectin MDA ↓ malaria incidence
Permethrin baby wraps ↓ infant malaria by 66%
Indoor residual spraying dramatically ↓ mosquitoes but not infections
Bottom line: endpoints are key 👇
1️⃣ Guidelines: Shorter, Oral, Individualized
2025 continues the trend toward less is more:
CAP: shorter courses (3–5 days) if stable
TB: 4-month regimens now endorsed for select patients
cUTI: oral step-down even with bacteremia is appropriate
Individualize guidance!👇
picture of books, with text: "essential publications in ID, 2025 edition"
🧵 Essential ID Papers for 2025: A Clinician’s Guide
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
Love this— adding it to my teaching folder. Thanks for sharing Lisa!
Nice work! @drrossanarosa.bsky.social have you found a disinfectant for inpatient rooms that can be used universally regardless of colonization status or do auris rooms get their own cleaning/disinfection protocol?
Welcome! We’re thrilled to have you.
Congrats!
Welcome!
Very cool!
Very cool thanks for sharing.
Congrats!
Let us know what you decide!
💔 so very sorry to hear
mount rainier
orca jumping in front of space needle
🚨📣🚨📣
We're hiring!
Open search for Associate Director of Infection Prevention at UW Medical Center
Work in amazing academic environment with a phenomenal team.
Fantastic quality of life.
Did I mention protected time for scholarly activities?
DM w q's
apply.interfolio.com/160509
#IDsky
@pergamic.bsky.social @johnlynchid.bsky.social @paulpottingermd.bsky.social @germhuntermd.bsky.social @drrossanarosa.bsky.social @jlsalinas.bsky.social
Graduating fellows with interests in scholarship, med-ed, IP and clinical service are welcome to apply!
mount rainier
orca jumping in front of space needle
🚨📣🚨📣
We're hiring!
Open search for Associate Director of Infection Prevention at UW Medical Center
Work in amazing academic environment with a phenomenal team.
Fantastic quality of life.
Did I mention protected time for scholarly activities?
DM w q's
apply.interfolio.com/160509
#IDsky
What a great match! Can’t wait to meet them.
Thanks for sharing
Amazing opportunity
Great thread, thank you!