Stem Cell Reports

Online now! Genome-engineered human pluripotent stem cells evade immune rejection in humanized mice, surviving 5 months in transplantation models. The study provides proof-of-principle for universal donor stem cells for regenerative medicine. https://ow.ly/eoiv50YqeT2

ISSCR

Online Now in Stem Cell Reports: A robust platform for investigating human oral epithelial development provides a valuable foundation for organoid-based research on oral organs. https://ow.ly/P8fr50YoFep

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New commentary reframes TNF in hematopoiesis. TNF’s effects are cell type-, context-, and time-dependent. Rather than being simply “bad,” TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity. https://ow.ly/sATS50YoF62

Lund University

Leiden University Medical Center co-cultured female human primordial germ cell-like cells (hPGCLCs) in two distinct niche compartments.  In both niches, stem cell factor was crucial for hPGCLC survival, highlighting that niche shifts are required for germ cell development https://ow.ly/oxkq50YoF3P

ASCL1 promotes nuclear shrinkage in #transdifferentiation by suppressing NUP37 and reducing the nuclear pore complex (NPC), which gates nuclear transport, suggesting a critical role of NPC in controlling nuclear size to match cell state. https://ow.ly/CfV950YoEua

ISSCR | Cell Press

New commentary from @umichdentistry.bsky.social proposes “regenesis” as an integrative framework to describe hybrid and intermediate tissue outcomes, moving beyond the traditional repair vs. regeneration binary in stem cell-based medicine. https://ow.ly/5XRr50YoEak

ISSCR | Cell Press

New study in Stem Cell Reports reveals a critical role for Shugoshin 2A (Sgo2a) in suppressing the 2-cell-like state to maintain the homeostasis and genome stability of embryonic stem cells #stemcells https://ow.ly/wIvh50YoE0c

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Stem Cell Reports is pleased to be the Official Meeting Journal of the 20th Annual Wisconsin Stem Cell Symposium, taking place 15 April in Fitchburg, Wisconsin, USA. Learn more: https://ow.ly/W2MI50Yn1oX

Help advance the field of stem cell science and regenerative medicine by serving as an Early Career Editor for ISSCR's society journal, Stem Cell Reports! Applications are due 13 March. Learn more: https://ow.ly/r7qw50XWbKR

New research from reNEW and The University of Copenhagen bridges structural chromatin changes during replication with functional outcomes, showing that replication creates a “window of opportunity” that advances the chromatin landscape during cell identity change. https://ow.ly/WltR50YimBG

Transcriptomic & multiplex immunostaining datasets demonstrate that #MYO5B is critical for intestinal epithelial stem & progenitor cell functions #MVID #intestine #stemcell #proliferation #differentation https://ow.ly/W9ZK50Yim7F

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Check out the editorial from Editor-in-Chief Janet Rossant: Enhancing rigor and reproducibility by implementing STAR Methods and the ISSCR Standards Checklist in Stem Cell Reports https://ow.ly/Yvyy50YiCc8

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

STEM-PD Trial: New research shows RC17 hESC-derived mesencephalic dopaminergic neural progenitor cells do not activate human T cells in vitro and reduced T cell CD25 expression and proliferation, supporting their immunological safety. https://ow.ly/iCa150YgFrY

ISSCR | Cell Press

New research from Regeneron highlights a previously unrecognized role of M-cadherin in fetal myofiber formation, showing it regulates the formation of adherens junctions and secondary myofibers to determine adult myofiber number and muscle mass. https://ow.ly/AiNa50YeyE8

ICYMI: A landmark guide for stem cell therapy authored by global leaders in stem cell and regenerative medicine research, including Sinai Health's Dr. Andras Nagy, Senior Investigator at #LTRI

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Online now! Acute estradiol/progesterone loss compromises the biology and function of neurogenic niches during a vulnerable female aging period, with hormone treatment rescuing neurological and behavioral deficits in female rats. https://ow.ly/ZN2h50YeyrT

New research from Leiden University Medical Center! A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells, and highlights how AI can scale assessment of drug-induced cardiotoxicity. https://ow.ly/Z2R450Yeymp

New research in Stem Cell Reports shows that the timing of embryonic stem cell differentiation is not directly determined by the cell cycle. https://ow.ly/uKyg50Yeygy

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

Improving rigor in stem cell research: New study in Stem Cell Reports highlights gaps in reporting and shows how implementing ISSCR standards can strengthen reproducibility in human stem cell studies. https://ow.ly/7PiO50Yey7Y

Cell Press | The Gairdner Foundation | SickKids Foundation

In the new Stem Cell Report podcast episode, guests discuss new approaches to improving the derivation & characterization of human sensory neurons through the development of a genetic toolkit to fluorescently label specific sensory neuron subtypes. https://ow.ly/G6Fx50YcyVO

Thrilled to see our latest work featured on the cover of Stem Cell Reports: www.cell.com/stem-cell-re... !

And thanks to Stem Cell Reports @stemcellreports.bsky.social and the ISSCR @isscr.org for highlighting our work!

Online now from University of New South Wales! In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia, informing future studies in delivering a more reliable standard therapy to improve clinical outcomes. https://ow.ly/lWWV50Yaerm

#STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism, providing insights into how its loss-of-function can contribute to increased type 2 #diabetes risk. https://ow.ly/ku9z50YexWR

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study shares an improved strategy to generate porcine induced pluripotent stem cells (piPSCs) with key features including flat morphology with feeder-free culture, #teratoma and #blastoid formation, and efficient CRISP-Cas9 editing. https://ow.ly/PpVM50Yaeeh

Serve the stem cell and regenerative medicine community by participating in the editorial review process as a Stem Cell Reports Early Career Editor. Applications are due 13 March. Learn more and apply: https://ow.ly/W09t50XWbgu

ISSCR | Mingxia Gu

Online now in Stem Cell Reports! Erythropoietin exposure disrupts B cell development and drives the emergence of myeloid-biased biphenotypic progenitors #lymphopoiesis #hematopoiesis #myelopoiesis https://ow.ly/Po5Q50YacSq

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study from Washington University in St. Louis is live in Stem Cell Reports: Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem cell lineage commitment. https://ow.ly/rxyU50YacMj

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

New study analyzes 532 RNA-seq datasets to map promoter activity in #hematopoiesis, providing insights into promoter-mediated regulation and a foundation for targeting promoter-specific mechanisms in disease.
ISSCR
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(26)00002-0

Ludovic Vallier (Vallier Lab), Stem Cell Reports Associate Editor, is attending the 4th Dubai Stem Cell Congress in Dubai today! Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!