Bloody brain 🧠
06.03.2026 19:12
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Bloody brain 🧠
for #fluorescencefriday we have the dance of blood vessels by @mind-western.bsky.social @shahrzadbahrampour.bsky.social @nadiahaghbinphd.bsky.social and Vladislav Novikov
#fluorescencefriday mapping the relationship between amyloid (green), microglia (magenta) and blood vessels (orange) in and aggressive model of AD. from @arashsalah.bsky.social @nadiahaghbinphd.bsky.social @shahrzadbahrampour.bsky.social @mind-western.bsky.social
#fluorescencedriday First attempt on NeuN labeling (magenta) to quantify the 3D distribution of neurons and interface with blood vessels (yellow) by @shahrzadbahrampour.bsky.social and @nadiahaghbinphd.bsky.social for the @mind-western.bsky.social @neuroak.bsky.social
A snow day for the brain — microglia mirroring winter’s touch ❄️!
#fluorescencefriday 🧠 from AppNL-G-F mouse model triple stained for amyloid beta (Cyan) IBA1 (microglia magenta) and CD31 (blood vessels yellow) thanks to @shahrzadbahrampour.bsky.social @nadiahaghbinphd.bsky.social and @arashsalah.bsky.social @mind-western.bsky.social
It's a Happy #FluorescenceFriday when we get a personal tour of the Western Lightsheet Microscopy Core, part of @touchscreencog.bsky.social + an integral part of #TRIDENT! 🧠 🔬 Sound intriguing? See more below🤓! @mind-western.bsky.social @lifecanvastech.bsky.social #NFRF
youtube.com/shorts/AA91I...
The TRIDENT proof-of-concept platform began in 2023 through the incredible support of a $24M grant from the Government of Canada's New Frontiers In Research Fund- Transformation stream.
Check out our website tridentpreclinicaltrials.org or the video below 👇 #NFRF
www.youtube.com/watch?v=RCr3...
#fluorescencefriday microglia (yellow) and Abeta plaques (magenta) in our AD mouse model in 3D from a cleared 🧠 using @lifecanvastech.bsky.social SHIELD Courtesy of @shahrzadbahrampour.bsky.social and @nadiahaghbinphd.bsky.social with @mind-western.bsky.social and @neuroak.bsky.social Low-res.
#fluorescencefriday shows some testing of ChAT staining in the mouse brain in cleared samples courtesy of @nadiahaghbinphd.bsky.social @mind-western.bsky.social
Great observation! Here’s an image from our dataset — the OB has a much higher vessel density than the rest of the brain, suggesting distinct vascular architecture. The video focus was set for brain contrast, causing overexposure in the highly vascular OBs.
Going for a rollercoaster ride on the spinal cord! 🤩
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
Lightsheet Meeting Series in Oct, @mind-western.bsky.social , pleasure to host Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @lifecanvastech.bsky.social @braincanada.bsky.social @maximoprado.bsky.social🔬🤩🧠
#fluorescencefriday Side by side comparison of alpha synuclein S129 (magenta), a marker of #parkinson’s , in M83 hemyzigous mice injected with human pre formed fibrils @shahrzadbahrampour.bsky.social Vlad Novikov clearing with SHIELD @lifecanvastech.bsky.social imaged at MIND platform @westernu.ca
Had a great time at the @mind-western.bsky.social Lightsheet Meeting Series this week, an amazing, interactive talk led by Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @braincanada.bsky.social @maximoprado.bsky.social🔬🖥️🤩
Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...
#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social
Great collaborative effort to get this done
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.
Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing
room 106
Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models
also poster 151
#FluorescenceFriday Testing a new microscope. Microglia (yellow) and S129 alpha synuclein (magenta) and nuclei (blue) spinning disc confocal image @leicamicrosystems.bsky.social
Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...
a second rendering for #fluorescencefriday
Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits
Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...
3D STED of PSD95-STAR RED, in cleared mouse brain tissue. 50% TauSTED 3D (left) and 100% TauSTED 3D (right), showing the difference in the axial resolution decrease from 274nm (left) to 143nm(right)! Sample prepared by Thomas Stroh group
Montreal Neurological Institute
(MNI). #MLMC 2025-July.
