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Christopher A. Baker

@bakermind

Firstgen Scientist in Yale Center for Infection and Immunity using imaging and transcriptomic technologies to alleviate pain in long COVID and similar syndromes.

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24.11.2024
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Latest posts by Christopher A. Baker @bakermind

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Astroengrams: rethinking the cellular substrate for memory - Nature Reviews Neuroscience Recent evidence suggests that astrocytes, through coordinated activation in sparse ensembles, contribute to memory traces — termed ‘astro-neuronal engrams’. In this Perspective, Sánchez Romero and Nav...

The ghost of Golgi arises to challenge Cajal
www.nature.com/articles/s41...

04.01.2026 13:37 👍 2 🔁 0 💬 0 📌 0

He died rather soon after this show. Then I knew I had seen something of importance

30.12.2025 16:56 👍 1 🔁 0 💬 0 📌 0

Looking back at the setlist, it was killer.
Help->Slipknot!->Franklin's
New Minglewood Blues
Easy to Love You
Peggy-O
Masterpiece
Brown Eyed Women
Cassidy
Deal

China Cat Sunflower
I Know You Rider
Looks Like Rain
Terrapin Station
drums
The Other One
Morning Dew

The Weight

30.12.2025 16:28 👍 2 🔁 0 💬 1 📌 0
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Dating myself, but I'm always excited to hear a streaming recording of a show where I was present. My voice from the past is coming back to me

30.12.2025 16:28 👍 2 🔁 0 💬 1 📌 0
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They once told you to never read the comments, but one of the best parts of social media nowadays is reading the comments on official government posts

09.12.2025 12:53 👍 1 🔁 0 💬 0 📌 0

Importantly, Kidd et al. IMPROVED the field and led to real genetic causes of autism or psychiatric disorders. But there are certainly environmental causes of childhood psychiatric disorders too. So the goal (hopefully) is not to necessarily disprove, but instead to IMPROVE 4/4

17.11.2025 22:06 👍 0 🔁 0 💬 0 📌 0

Some disagree: one of my mentors warned against spending too much effort to disprove flawed assertions. Gotta light a candle, perhaps. Kidd not only cleaned up the literature but made seminal contributions (importance of considering diversity in genetic studies, ironically) 3/

17.11.2025 22:06 👍 0 🔁 0 💬 1 📌 0
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a cartoon character from south park says yeah a lot of the guys here are posers so you gotta be careful . ALT: a cartoon character from south park says yeah a lot of the guys here are posers so you gotta be careful .

It's common for a field to develop "trendy" topics (I'm old enough to remember nNOS) and also trendy to tear down trendy topics. Such criticism is still important (e.g. Ken Kidd helped a lot by removing spurious genetic association studies in psychiatric disease) 2/

17.11.2025 22:06 👍 0 🔁 0 💬 1 📌 0

I've been a fan of @wiringthebrain.bsky.social for many years and notice that he spent a lot of time criticizing epigenetics and now he's laying into gut-brain axis. 🧵 1/

17.11.2025 22:06 👍 1 🔁 0 💬 1 📌 0
Crystal-Clear Coffee Negroni : A Game-Changing Technique
Crystal-Clear Coffee Negroni : A Game-Changing Technique YouTube video by Truffles On The Rocks

Happy neuroscience?
Saw this and thought you might try it. It involves several things you love youtu.be/bHOE-5uR3Xg?...

17.11.2025 22:03 👍 2 🔁 0 💬 1 📌 0
Facts Don't Win Buy-In (Learn What Actually Does)
Facts Don't Win Buy-In (Learn What Actually Does) YouTube video by Dr. Grace Lee

This essential truth applies to vaccine debates, political issues, and public trust of scientists: facts only helps humans justify the choice they are already making. To persuade anyone you must appeal to personal safety and identity first.
youtu.be/dtxjpLCVTMQ?...

16.11.2025 15:54 👍 0 🔁 0 💬 0 📌 0
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Which Renaissance painting is this

06.11.2025 22:34 👍 0 🔁 0 💬 0 📌 0
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Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

The first paper for this year's medicine Nobel was NOT published in Science, Nature, or Cell. www.nobelprize.org/prizes/medic...

06.10.2025 15:00 👍 0 🔁 0 💬 0 📌 0

Seems like those suing are non-profits, and those not suing are corporations. What's worth exploring is whether tech STARTUPS will sue, because the $100K system favors tech giants that can easily absorb the excess cost

06.10.2025 01:14 👍 0 🔁 0 💬 0 📌 0

My wife keeps telling me about that place. We're in Connecticut now and it seems so close but also so far if you know what I mean

06.10.2025 01:07 👍 1 🔁 0 💬 1 📌 0

... the right has been quite adept at this, simply bathing in hypocrisy as required to achieve the ends of destroying progressive and centrist ideals. Should the left take the same road? Or will holding to their ideals actually be the better choice for attracting support based on authenticity?

06.10.2025 01:06 👍 0 🔁 0 💬 0 📌 0

It's interesting work that highlights a typical poltical problem: ideology versus pragmatism. Making an ethical stand is important, but some consider that such stands might be futile unless power is achieved through pragmatic actions that might require compromising one's ethics...

06.10.2025 01:06 👍 2 🔁 0 💬 1 📌 0

What's the point? It's deserted? That's capitalism at work I guess

06.10.2025 00:55 👍 2 🔁 0 💬 0 📌 0

💯
When not private equity, it's often just greed or topheaviness

02.10.2025 10:38 👍 0 🔁 0 💬 0 📌 0

The one critique that shocked me was: "The NIH Director has never been the PI on an NIH grant". Not sure if that's true but I'm not surprised

30.09.2025 12:09 👍 4 🔁 1 💬 0 📌 0
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So glad I've spent the last couple of days in the woods immersed in science and teamwork with @virusesimmunity.bsky.social, @yalecii.bsky.social, and colleagues, unplugged from media for the most part

13.09.2025 13:02 👍 2 🔁 0 💬 1 📌 0

Lol it's just for the photo - intent was to get the Sound in the background. Definitely not keeping the glass on that railing

05.09.2025 23:40 👍 2 🔁 0 💬 0 📌 0

That was Dennis Kucinich's idea. At least it was novel. Trump just went back to his favorite era: 1938. I remember last week when Trump said he stopped 7 wars and should get the Peace Prize; now he's all in on war

05.09.2025 23:35 👍 1 🔁 0 💬 0 📌 0
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I made a chartreuse swizzle to start

05.09.2025 23:31 👍 2 🔁 0 💬 1 📌 0
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A farewell to the summer with a suggestion from @anderseriksson.bsky.social : it's not Mountain Dew; it's a chartreuse swizzle (Chartreuse, pineapple juice, lime juice and falernum), which is orders of magnitude more expensive (glass from Cognitive Surplus)

05.09.2025 23:29 👍 0 🔁 0 💬 0 📌 0

Thank you for reaching out.
Yes some people were concerned about what I had disclosed, and others began to harass me just for being a researcher in the field. I deactivated the account to remove the previous disclosures and take a break from some of the haters

13.08.2025 16:26 👍 1 🔁 0 💬 1 📌 0

This paper is suggestive but not conclusive - it shows that dumping spike protein on human retina cultures induces beta amyloid that colocalizes with spike, and that similar colocalization is detected in postmortem retina from COVID patients. Very thought-provoking nevertheless

09.07.2025 14:54 👍 0 🔁 0 💬 0 📌 0
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids You have to enable JavaScript in your browser's settings in order to use the eReader.

intersection of SARS-CoV-2 and beta amyloid gets at concepts that have bugged me for years: 1) that amyloid deposition is an antecedent of infection or host defense, and 2) that spike protein itself may have amyloidogenic properties. science.org/doi/epdf/10....

09.07.2025 14:54 👍 0 🔁 0 💬 1 📌 0
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I made a post earlier about Fluorescence Friday, but some people say it's Fascist Friday because of the ouster of UVA president... to which I say I'm still going to do science for the public interest for as long as I can

27.06.2025 18:35 👍 2 🔁 0 💬 0 📌 0
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The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour - Nature A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

new pathway discovered by Tomomi Yoshida, Andrew Wang, and tons of other great @Yale folks, described in this recent report @ Nature www.nature.com/articles/s41...

27.06.2025 18:28 👍 0 🔁 0 💬 0 📌 0