Helfrid Hochegger

UK research councils pause applications for major research grants - The Economic Times Three major UK research councils have temporarily halted applications for several funding programmes, sparking concerns among scientists about potential research spending cuts. The Medical Research Co...

I sure hope this is fake news! economictimes.indiatimes.com/nri/study/uk...

Every year, I inch further and further towards the southwest of this graph.

From Sendai to Kyoto: the HFSP Science Summit Japan 2025 connected outstanding scientists and young researchers in a week of collaboration and discovery.
📖 Read the full story → zurl.co/5eYb5
🧪 #sts #HFSPSummitJapan

Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...

From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.

wi.mit.edu/news/alterna...

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...

Claude for Life Sciences Discover how Claude accelerates life sciences research with new scientific connectors, skills, and improved performance for drug discovery and clinical work.

Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵

www.anthropic.com/news/claude-...

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

I would if I didn’t have a job already:-) super interesting project and great lab to work in!

Just over one week until this opportunity closes!

If you’re an ambitious computational scientist looking for a Postdoc position, apply now

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.

Periodic excretion patterns of seabirds in flight Uesaka and Sato report on the excretion patterns of seabirds in the open ocean determined using a rear-facing video logger.

@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...

As universities, we need to do better!

What resources does your institution provide? What more should we be doing?

Thanks to @restispolitics.bsky.social for raising this!

As students come back to campus in the UK, 8% of female students are likely to experience rape during their undergraduate years, especially in the first months of their studies.

revoltsexualassault.com/wp-content/u...

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

Beautiful work! Congrats.

Thanks for sharing our work @bladoux.bsky.social (you just made the lead author @marcoenriquez18.bsky.social very happy 😊)

Blood cancer awareness month. Image from Blood Cancer UK campaign. "It takes Science and Stubbornness".

Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

RNA Pol II inhibition activates cell death independently from the loss of transcription When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...

I’m excited to highlight our latest paper, just published in Cell 🎉

We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.

1/n 🧪

www.cell.com/cell/fulltex...

... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.

Fantastic team effort led by Robert Zach.
Special thanks to @CR_UK and @wellcometrust for support and the many other authors to make this collaboration possible 🙏. Happy to discuss the work - comments and questions welcome!

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...

We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply:
www.sussex.ac.uk/study/fees-f...

PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.

Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you

url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.

www.nature.com/articles/s41...

Lovely retrospective for Dan Dennett.

Zotero is the way

Thanks to the @simplyoncology.bsky.social guys for this opportunity to talk about everything high grade glioma!