@divyankm
Rationalist. Scientist. PhD. Proteomics & Phosphoproteomics. Tumor hypoxia. Intrstd in •Evolution of & acquired chemoresistance •Gene Regulation & its evolution •AI led DD Skilled: Proteomics, genomics, sc-&spatial-transc, mol-cell bio, drug screening
I would strongly put the blame on prevalent, subconscious reductionist thinking. More systems thinking (in general) the community starts to become, more interdisciplinary we'll see.
Perplexity works better in this sense. It even provides citations (not made up as chatgpt) for any scientific query as well.
Yeah..but fast production of papers i.e. being prolific is so much promoted/looked for. Also which is dependent on funding.
Slow "real science" therefore slows your career trajectory?
Hello! Could you pls allow DM here for discussing this?
What could be possible cellular/biological reason(s) for change in transcripts/transcriptome not being consistent with changes in respective proteins/proteome?
What advantage would it give a biosystem to make RNA if not to be translated?
If you think research is expensive, try disease.
-- Mary Lasker
Penning down after a while
A great support system really forces you to become the best version of yourself.🫶🏽
Explorer, philosopher, sometimes poet.
'I much prefer the British spelling of “diarrhea” which is “diarrhoea” because it looks like you’ve lost control of your vowels.' -- Sal Robins
Doing good science is 90% finding a science buddy to constantly talk to about the project.
Would you be hiring wet-lab postdocs too?
#NatureReviewsCancer🚨
The #CancerDepMap is an invaluable, publicly available resource for systemically identifying cancer vulnerabilities. In this #Perspective, Bill Hahn & team (@broadinstitute.org) review its impact, uses, limitations & efforts to improve + expand its use.
go.nature.com/4fiZ6sw
Stephen Jay Gould talks in his book Bully for Brontosaurus about non-adaptive mechanism of evolution in NZ kiwis and their eggs.
How far have come..? in knowing of phenotypes which have come off just as by-the-way or as compensatory needs?.
Biomolecular condensates are frequently discussed in the context of different cellular processes.
This Review is dedicated to their function in the regulation of transcription. @bsabari.bsky.social et al. discuss condensate organisation and their impact on gene activation in development & disease.
Naïve question: When RNA Polymerase finishes transcription and detaches from DNA, does it do so as an intact complex, or does it have to split apart to release the DNA strand it's been encircling?