Isa Moreno

It’s finally here! 🎉
Delayed a bit by the classic post-PhD lab change, but very happy to see this work published. Thank you @lionelguy.bsky.social and @sellinlab.bsky.social 😄

Finally out! Did you ever wonder how a phylum with 10 core genes can make a conserved organelle? Read the paper! It's all about intrinsically disordered proteins! | PNAS www.pnas.org/doi/10.1073/...

Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts Abstract. Legionella pneumophila is an endosymbiotic bacterial species able to infect and reproduce in various protist and human hosts. Upon entry into hum

Moreno, @lionelguy.bsky.social et al. applied experimental evolution to identify genes conferring host specificity to L. pneumophila, highlighting the importance of mutations targeting the LerC protein and the LPS synthesis cluster.

🔗 doi.org/10.1093/molbev/msaf161

#evolbio #molbio #legionella

Nucleocytoviricota viral factories are transient organelles made by liquid-liquid phase separation Phase separation is a widespread mechanism in viral processes, mediating replication, host manipulation and virion morphogenesis. The phylum Nucleocytoviricota encompasses diverse and ubiquitous virus...

Here our revised version of our manuscript defining viral factories as biomolecular condensates. Hope you enjoy the reading.
www.biorxiv.org/content/10.1...