Olivia C. Ghirardelli Smith

Cold memories control whole-body thermoregulatory responses - Nature Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

We all know how powerful memories can feel, but new work published in @nature.com shows that the memory of being exposed to cold conditions in a specific environment can alter a mouse's whole-body metabolism 🧪 www.nature.com/articles/s41...

Frontiers | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient

Check out the case report we wrote on a fascinating case of teratoma in the testes. This case illustrates that pure mature teratomas occurring in postpubertal males cannot invariably be classified into the benign teratoma category.

www.frontiersin.org/journals/onc...

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social

YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)

Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma - Nature Communications VEGF-C induced lymphangiogenesis combined with immunotherapy approaches can promote anti-tumor immune responses. Here the authors report that lymphaticderived oxysterols promote anti-tumor immunity an...

#WeekendRead! #LipidPower! Hugues, Sun &co show @natcomms.bsky.social that lymphatic endothelial cells #LECs modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses during immunotherapy!!

This is figure 3, which shows TRIM28-dependent developmental heterogeneity primes cancer outcomes.

A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

Excited to share my PhD work from Rafi Ahmed’s lab, now published in @nature.com. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for a non-prescient immune system! tinyurl.com/53nrpsa6

#Immunology out now @science.org

ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.

https://buff.ly/42iBst0

How are durable antibody-responses to vaccines induced? News & Views paper discussing excellent new work by Cortese et al in Nature Immunology: www.nature.com/articles/s41...
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky

This paper is now online: www.nature.com/articles/s41... and it is fascinating!!

Excited for the CellSymposia "Neuro-immune Axis: Charting the Periphery" in New York City Sept 7-9, 2025, in partnership with the Allen Discovery Center for Neuroimmune Interactions! Keynotes: David Julius & @tcellogic.bsky.social. Check out the speaker list! www.cell-symposia.com/neuroimmunol...

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...

Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...

Another beautiful example of @victora.bsky.social 's LIPSTIC ("labeling immune partnerships by sorTagging intercellular contacts") technique in action!

Outstanding work from @KKellermanUCCOM @JankowskiLab @CincyImmunology @CincyMSTP @RothenbergLab @CincyResearch identifying a neuroimmune circuit involving IL-4 and NaV1.8+ sensory nerves that regulates allergic inflammation in the esophagus
www.biorxiv.org/content/10.1...

Meningeal neutrophil immune signaling influences behavioral adaptation following threat Wu et al. demonstrate how neutrophils, located within the protective layers of the brain, respond to social threats and modulate psychological processes. This process is governed by testosterone in a ...

www.cell.com/neuron/fullt...

Hi Kueh lab, thank you for setting this up, I would love to be added and recommend my fellow Masopust labmate @buck-oflanagan.bsky.social as well

I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added.

Looking forward to scientific discussions and updates on our favorite immune cell type!

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Intramuscular mRNA vaccination induces pulmonary resident memory T cells that can be further expanded with intranasal boosting.

How does route of mRNA vaccination impact localization and abundance of memory T cells? shorturl.at/foBMY.

Hi Anna, I would love to be added! Thank you!

Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k

Hi Jon, I would love to be added! Thanks!

Hi Tobias, please add me!

Ever wondered what T cell immunosurveillance of 🐭 mammary ducts looks like? Check out our image featured on the cover of Science Immunology, showing CD103+ (pink) antiviral memory T cells (cyan) w/ in the ductal epithelium 🤩

Beyond grateful to receive an F30 from NIAID! This award will support my training in the Masopust lab studying how resident memory T cells communicate with the rest of the body 🗣️ Thank you to many in UMN MSTP, CFI, and beyond for the support.