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Diabetologia

@diabetologiajnl

We publish high-quality, cutting edge articles on all aspects of diabetes, from basic science through translational work to clinical research

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15.11.2024
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Latest posts by Diabetologia @diabetologiajnl

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GlucoseGo: a simple tool to predict hypoglycaemia during exercise in type 1 diabetes - Diabetologia Aims/hypothesis This study aimed to develop an accessible tool, derived using machine learning, to predict hypoglycaemia risk at the start of exercise and to provide clear, rapid risk assessment to su...

New data on #GlucoseGo, a simple tool developed with machine learning, which predicts hypoglycaemia risk in #Type1Diabetes, just using starting glucose & exercise duration. Supporting safer workouts! πŸƒβ€β™€οΈπŸ’‘πŸ©Ί #DiabetesResearch #T1DExercise link.springer.com/article/10.1... πŸ”“

10.03.2026 11:55 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1 - Diabetologia Aims/hypothesis A highly specific mosaic transcriptional environment guides the fate of pancreatic progenitors during development and maintains the identity of mature endocrine cells. In mice, one suc...

Up front & free to read in our March issue #editorspicks: MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1 doi.org/10.1007/s001...

10.03.2026 11:18 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion - Diabetolo... Aims/hypothesis The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts tha...

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1... πŸ”“

09.03.2026 10:34 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Mitochondrial cristae density is trainable in human skeletal muscle rdcu.be/e7pc5

Thanks to the reviewers and @diabetologiajnl.bsky.social for the constructive feedback and for publishing our work.

Thread below:

08.03.2026 11:07 πŸ‘ 6 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Promotional graphic announcing a call for applications for the EASD Albert Renold Travel Fellowship Programme. The text explains that the programme enables scientists and clinicians to advance their diabetes research projects by learning specific techniques or clinical skills at other institutions. The design features teal and green geometric shapes, an image of a laboratory pipette dispensing liquid into test tubes on the right, the EFSD logo at the bottom left, and the website europeandiabetesfoundation.org at the bottom right.

Promotional graphic announcing a call for applications for the EASD Albert Renold Travel Fellowship Programme. The text explains that the programme enables scientists and clinicians to advance their diabetes research projects by learning specific techniques or clinical skills at other institutions. The design features teal and green geometric shapes, an image of a laboratory pipette dispensing liquid into test tubes on the right, the EFSD logo at the bottom left, and the website europeandiabetesfoundation.org at the bottom right.

πŸ“’ The Albert Renold Travel Fellowship programme is open for applications! Don’t miss out - apply now to boost your #earlycareer journey:
βœ…Receive up to €10,000
βœ…3months research stay

πŸ“… Deadline: 15 April 2026

Apply via the #EFSD Programme Portal πŸ‘‰ www.europeandiabetesfoundation.org/programmes/p...

05.03.2026 09:47 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Impact of cardiovascular autonomic neuropathy on cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes - Diabetologia Aims/hypothesis The aim of this work was to compare the cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes with or without cardiovascular auto...

Up front & free to read in our March issue #editorspicks: Impact of cardiovascular autonomic neuropathy on cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes doi.org/10.1007/s001...

06.03.2026 16:21 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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Fully closed-loop systems: can people with type 1 diabetes just do it? Insights from open-source systems - Diabetologia Automated insulin delivery (AID) systems have significantly advanced diabetes management, progressively reducing user interactions required for optimal glucose management. This review evaluates the cu...

Up front & free to read in our March issue #editorspicks: Fully closed‑loop systems: can people with type 1 diabetes just do it? Insights from open‑source systems doi.org/10.1007/s001...

06.03.2026 08:07 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial - Diabetologia Aims/hypothesis We aimed to investigate canagliflozin’s effects on myocardial fibrosis, cardiac structure and function, and microcirculation in high-cardiovascular-risk type 2 diabetes mellitus throug...

Novel RCT: Canagliflozin reduces myocardial fibrosis (by CMR) in high-risk #T2DM, providing imaging evidence for its cardioprotection. A mechanism beyond glycaemic management. #SGLT2i #CardioDiabetes #HeartFailure #DiabetesResearch link.springer.com/article/10.1... πŸ”“

05.03.2026 11:34 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Maternal pre-pregnancy BMI differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus pregnancies, with alkalinisation-associated reduction of ade... Aims/hypothesis Gestational diabetes mellitus (GDM) is associated with fetoplacental endothelial dysfunction, including impaired extracellular clearance of adenosine, a vasodilator, in HUVECs. This st...

Maternal pre-pregnancy BMI defines distinct fetoplacental endothelial phenotypes, shaping intracellular pH regulation, NHE1 activity and adenosine transport. Precision stratification may refine risk assessment in #GDM #BMI #Pregnancy link.springer.com/article/10.1...

05.03.2026 11:32 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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πŸ”’ Cost is certainly a factor why only 15% of the 8 million people living with #T1D use an #AIDsystem. Inge Van Boxelaer points towards #opensource software to increase access in our latest #ExpertsInsights episode.

πŸ“Ί Watch it here: easd-elearning.eu/episode/360/...

#diabetes #technology

04.03.2026 12:59 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes - Diabetologia Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes mellitus. Despite its importance, non-adherence remains a prevalent issue, with...

Up front & free to read in our March issue #editorspicks: Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes doi.org/10.1007/s001...

04.03.2026 15:11 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle - Diabetologia Aims/hypothesis Exercise elicits a spectrum of metabolic and inflammatory responses that are crucial for skeletal muscle adaptation and overall health, particularly in the context of metabolic disease...

New study from @ki.se shows that exercise induces macrophage-derived thromboxane in skeletal muscle, enhancing glucose uptake and improving glucose tolerance in mice link.springer.com/article/10.1... πŸ”“ @nicopillon.bsky.social

03.03.2026 14:16 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
Promotional graphic for EASD 2026 announcing the EASD Annual Meeting, taking place 28 September - 2 October 2026 in Milan, Italy. The text reads β€œRegister now for the EASD Annual Meeting! Join us in Milan to discover what’s next in diabetes science and care.” The design features red and white blocks with stylised silhouettes of Milan landmarks on the right, the EASD 2026 Milan logo at the bottom left, and easd.org at the bottom right.

Promotional graphic for EASD 2026 announcing the EASD Annual Meeting, taking place 28 September - 2 October 2026 in Milan, Italy. The text reads β€œRegister now for the EASD Annual Meeting! Join us in Milan to discover what’s next in diabetes science and care.” The design features red and white blocks with stylised silhouettes of Milan landmarks on the right, the EASD 2026 Milan logo at the bottom left, and easd.org at the bottom right.

πŸ“’ Registration is officially OPEN for #EASD2026!

Join us in Milan or virtually from 28 September - 2 October 2026 for the 62nd EASD Annual Meeting!

βœ…World-class science
βœ…Networking & industry insights

Register now via MyEASD: www.easd.org/annual-meeti...

#Diabetes #Registration

03.03.2026 10:31 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Webinar Series promotional graphic from EASD Early Career Academy. It lists: Date - 5 March 2026, 16:30 CET; Guest - Prof. Amalia Gastaldelli, National Research Council, Italy; Topic - β€œCould we change the course of MASLD - what is available and what is in the pipeline?” The EASD logo appears at the bottom left and the website easd.org/academy at the bottom right.

Webinar Series promotional graphic from EASD Early Career Academy. It lists: Date - 5 March 2026, 16:30 CET; Guest - Prof. Amalia Gastaldelli, National Research Council, Italy; Topic - β€œCould we change the course of MASLD - what is available and what is in the pipeline?” The EASD logo appears at the bottom left and the website easd.org/academy at the bottom right.

πŸŽ₯This week, our EASD Early Career Academy is hosting a #webinar w. Prof. Amy Gastaldelli, co-author of the @easlnews.bsky.social Guidance on the full steatotic #liverdisease trajectory on #MASLD: treatments & what's next.

πŸ“… 5 March 2026 |πŸ•› 16:30 CET

πŸ‘‰ Register now: us06web.zoom.us/webinar/regi...

02.03.2026 13:06 πŸ‘ 6 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Real-world evidence on the CamAPS FX hybrid closed-loop system in people living with type 1 diabetes - Metabologia Metabologia - We analysed real-world data to evaluate the performance of the CamAPS FX hybrid closed-loop system I people living with type 1 diabetes. Users from 19 countries across different age...

Real-world evidence from >35,000 users demonstrates the performance of the CamAPS FX hybrid closed-loop system with outcomes comparable to those reported from previous randomised controlled studies link.springer.com/article/10.1... πŸ”“

02.03.2026 10:45 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Our March cover illustrates the β€˜rhythm of duodenal myoelectrical activity’. In this issue, Yun et al report that antro-duodenal electrical stimulation mimics RYGB surgery to restore glucose homeostasis and may present an alternative treatment for #T2D link.springer.com/article/10.1...

02.03.2026 08:45 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Subtypes of newly diagnosed type 2 diabetes and risk of complications: analysis of electronic health records in the USA - Diabetologia Aims/hypothesis Data-driven subtyping of type 2 diabetes has not been translated into clinical practice due to the lack of routine fasting glucose and insulin measurements. We aimed to identify type 2...

In a nationwide study, we identified type 2 diabetes subtypes using electronic health records in the USA, revealing distinct risks of vascular complications and opportunities to advance precision medicine in routine clinical care #T2D #DiabetesResearch link.springer.com/article/10.1...

02.03.2026 08:43 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Graphic with a blue gradient background announcing β€œCall for nominations - EASD Honorary Membership 2026.” The text invites members to submit nominations for lifetime EASD Honorary Membership. The EASD logo appears at the bottom left, and the website β€œeasd.org” is shown at the bottom right, with circular design elements on the right side of the image.

Graphic with a blue gradient background announcing β€œCall for nominations - EASD Honorary Membership 2026.” The text invites members to submit nominations for lifetime EASD Honorary Membership. The EASD logo appears at the bottom left, and the website β€œeasd.org” is shown at the bottom right, with circular design elements on the right side of the image.

πŸ“’ Call for Nominations: EASD Honorary Membership 2026
Nominate a colleague who has made outstanding contributions to diabetes #research and the EASD community.

πŸ“© Deadline: πŸ“… 27 March 2026 | πŸ•› 23:59 CET

Learn more: www.easd.org/membership/h...

#diabetes #HonoraryMembership #Nominations

26.02.2026 10:51 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Promotional EASD graphic showing a panel discussion. On the left, Prof. Nita Forouhi (University of Cambridge) and Prof. Michael Lean (University of Glasgow) are seated on stage, each holding an EASD-branded microphone. The right side features EASD branding and a stylised audio waveform. The title reads: β€œTailored nutrition and low-calorie diet remission updates.”

Promotional EASD graphic showing a panel discussion. On the left, Prof. Nita Forouhi (University of Cambridge) and Prof. Michael Lean (University of Glasgow) are seated on stage, each holding an EASD-branded microphone. The right side features EASD branding and a stylised audio waveform. The title reads: β€œTailored nutrition and low-calorie diet remission updates.”

πŸŽ™οΈ Can #type2diabetes be reversed? Weight loss & whole-food nutrition hold the key.

Experts Prof. Nita Forouhi and Prof. Michael Lean discuss ultra processed foods, meat and #diabetes remission in a new must-hear #podcast episode.

πŸŽ§πŸ‘‰ Listen now: www.easd.org/media-centre...

27.02.2026 10:35 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Type 1 diabetes, ageing and frailty: an underexplored intersection - Diabetologia Over recent decades, the life expectancy of individuals with type 1 diabetes has steadily improved due to advances in therapies that enhance metabolic control alongside better prevention and managemen...

People with T1D are increasingly reaching older age, with heterogeneous ageing trajectories. This review explores frailty, sarcopenia, cognitive impairment & implications for personalised geriatric-informed diabetes care
link.springer.com/article/10.1... πŸ”“

26.02.2026 16:22 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
Figure 1: The four person-centred priorities for the design and implementation of AI-driven clinical decision support systems (AI-CDSS).

Figure 1: The four person-centred priorities for the design and implementation of AI-driven clinical decision support systems (AI-CDSS).

A new consensus roadmap with 14 recommendations to guide the use of #AI in #diabetescare is out! It aims to improve workflows & reduce administrative burdens amongst others,explain @barttorbeyns.bsky.social & Stefano Del Prato from the @eudiabetesforum.bsky.social.πŸ”— easd-elearning.eu/news/461/Rea...

25.02.2026 13:21 πŸ‘ 6 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Geospatial clustering of type 1 diabetes in Sweden: a cohort study based on all residential locations from birth to diagnosis - Diabetologia Aims/hypothesis Type 1 diabetes develops gradually, and previous exposures may influence incidence. We aimed to assess the geographical variation in type 1 diabetes incidence in Sweden by considering ...

Incidence of type 1 #diabetes in Sweden is highest in rural, central areas &lowest in urban areas. Strongest patterns link to early childhood residence, suggesting local environmental factors influence the risk of #T1D #DiabetesResearch link.springer.com/article/10.1... πŸ”“

25.02.2026 08:09 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Exercise in type 1 diabetes: real-world data on glucose levels and hypoglycaemia risk from over 420,000 exercise sessions - Diabetologia Aims/hypothesis This large observational cohort real-world study explored the effects of three forms of exercise (walking [WALK], aerobic excluding walking [AER] and anaerobic [ANAER]) on glucose leve...

How does exercise impact glucose levels in T1D? Analysis of 428,058 exercise sessions shows aerobic exercise lowers glucose more than anaerobic, with greater 24 h glycaemic benefits but higher acute hypoglycaemia risk. #T1D #Diabetes #Exercise link.springer.com/article/10.1... πŸ”“

24.02.2026 19:39 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Novel deuterium metabolic imaging technique reveals distinct patterns of postprandial hepatic glucose homeostasis in individuals with type 1 diabetes and healthy control individuals: a case–control st... Aims/hypothesis Subcutaneous insulin delivery in individuals with insulin-deficient type 1 diabetes bypasses the portal circulation, disrupting the physiological porto-systemic insulin gradient and af...

Study exploits a novel deuterium metabolic imaging technique to reveal distinct patterns of postprandial hepatic glucose homeostasis in patients with type 1 #diabetes, comparing them to healthy controls. #liver #glucose #metabolism #deuterium link.springer.com/article/10.1... πŸ”“

24.02.2026 09:56 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Promotional graphic for EASD featuring a panel discussion titled β€œRecurrent severe hypoglycaemic events: What to do?” On the left, three seated speakers hold blue EASD-branded microphones. From left to right: Prof. J. Hans DeVries (University of Amsterdam), Prof. James A.M. Shaw (Newcastle University), and Prof. Jane Speight (Deakin University). They are seated in black armchairs against a wooden wall, engaged in conversation. The right side of the image has a blue graphic background with the EASD logo and a stylised white audio waveform across the centre.

Promotional graphic for EASD featuring a panel discussion titled β€œRecurrent severe hypoglycaemic events: What to do?” On the left, three seated speakers hold blue EASD-branded microphones. From left to right: Prof. J. Hans DeVries (University of Amsterdam), Prof. James A.M. Shaw (Newcastle University), and Prof. Jane Speight (Deakin University). They are seated in black armchairs against a wooden wall, engaged in conversation. The right side of the image has a blue graphic background with the EASD logo and a stylised white audio waveform across the centre.

πŸŽ™οΈβš οΈ Severe #hypoglycaemia remains a major fear in type 1 #diabetes . Even with #CGM & #AID , risk isn’t eliminated & how does #Psychology shape prevention?

A vital discussion w. experts Prof. J. Hans De Vries, Prof. James Shaw & Prof. @janespeight.bsky.social .

πŸŽ§πŸ‘‰ www.easd.org/media-centre...

20.02.2026 11:59 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Promotional graphic reading β€œCall for Applications - EFSD/Novo Nordisk Foundation Future Leaders Award Programme.” Text explains the programme supports clinical and basic scientists in European diabetes research as they transition to tenured academic appointments and develop into future leaders. On the right, a close-up image shows a researcher using a microscope. The EFSD logo and the website β€œeuropeandiabetesfoundation.org” appear at the bottom, set against a teal and green abstract background.

Promotional graphic reading β€œCall for Applications - EFSD/Novo Nordisk Foundation Future Leaders Award Programme.” Text explains the programme supports clinical and basic scientists in European diabetes research as they transition to tenured academic appointments and develop into future leaders. On the right, a close-up image shows a researcher using a microscope. The EFSD logo and the website β€œeuropeandiabetesfoundation.org” appear at the bottom, set against a teal and green abstract background.

πŸš€ Take the next step in your #diabetes #research career & apply for the #EFSD/@novonordiskfond Future Leaders Award Programme today - support the next generation of diabetes research leaders in #EU!

πŸ“… Deadline: 2 Mar 2026 |πŸ•› 12:00 CET

πŸ”—πŸ‘‰Apply now: www.europeandiabetesfoundation.org/programmes/p...

19.02.2026 09:59 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Red and green skateboards carrying molecules on a wave. The cover illustration is a representation of the discovery that reprogramming duodenal myoelectrical hyperactivity drives diabetes remission. A central waveform depicts myoelectrical signals shifting from red (diabetic state) towards blue-green (recovery), while insulin molecules, electrical symbols and beta cell icons dynamically align with the rhythm.

Red and green skateboards carrying molecules on a wave. The cover illustration is a representation of the discovery that reprogramming duodenal myoelectrical hyperactivity drives diabetes remission. A central waveform depicts myoelectrical signals shifting from red (diabetic state) towards blue-green (recovery), while insulin molecules, electrical symbols and beta cell icons dynamically align with the rhythm.

Our March issue is online now! link.springer.com/journal/125/...

19.02.2026 13:22 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort - Diabetologia Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whet...

Higher frequency of beef intake during childhood, but not pork, was associated with increased risk of type 1 diabetes in genetically predisposed individuals. Findings from the Swedish ABIS cohort. @amlampousi.bsky.social @ki.se #T1D #DiabetesResearch link.springer.com/article/10.1... πŸ”“

19.02.2026 11:02 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
EASD branded hiring graphic with the text: 'We are hiring! Scientific Research Coordinator - For an EU-wide research project on the early treatment of type 2 diabetes. easd.org'

EASD branded hiring graphic with the text: 'We are hiring! Scientific Research Coordinator - For an EU-wide research project on the early treatment of type 2 diabetes. easd.org'

πŸ“’ Hiring: we're looking for a motivated Scientific Research Coordinator to join our team. Unique opportunity to shape an EU-wide research project on the early treatment of #type2diabetes.

βœ…18 months (potential extension)
βœ…RemoteπŸ‡ͺπŸ‡Ί/ DΓΌsseldorfπŸ‡©πŸ‡ͺ

Apply now πŸ‘‰ www.easd.org/uploads/JobA...

18.02.2026 10:01 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0