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Louise Marston

@proflouisemarston

Professor of Clinical Trials Statistics at Priment Clinical Trials Unit, UCL. England rugby fan, Trailfinders Women. Often out taking photographs.

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16.11.2024
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Latest posts by Louise Marston @proflouisemarston

Great pics. Hope you had an enjoyable trip.

28.02.2026 14:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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SPCR Studentships in Primary Health Care

NIHR School of Primary Care Research (SPCR) #PhDStudentship opportunity at UCL πŸ“£

Applications are invited from individuals with a strong academic record who wish to develop a career in primary care research.

Deadline: Monday 23rd March at 12pm. www.spcr.nihr.ac.uk/career-devel...

18.02.2026 09:49 πŸ‘ 17 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0

Not raining near Kew, but expect to get wet when I am out this evening.

13.02.2026 17:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Kew did PPI for its Kew Orchids 2026! Kew did PPI for its Kew Orchids 2026!

@rbgkew.bsky.social had a public involvement panel for #KewOrchids! www.flickr.com/photos/louis...

09.02.2026 19:13 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Research Our programme of internationally competitive research addresses the management and prevention of disease in high-priority areas of health.

πŸš€ NIHR SPCR PhD Studentships now open at UCL PCPH!
We’re inviting applications from outstanding candidates interested in developing a career in primary care research.
πŸ“… Start: October 2026
More info:
PCPH research: www.ucl.ac.uk/population-h...
SPCR studentships: www.spcr.nihr.ac.uk/career-devel...

30.01.2026 11:49 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Well done Jack!

30.01.2026 11:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The bin men will usually collect them if they are left out on a specific day.

07.01.2026 15:30 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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PhD Studentship Opportunity: TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using Natural Language Processing - Opportunities at UCL 93352 Find out more from about PhD Studentship Opportunity: TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using Natural Language Processing at UCL at Postgraduate Studentships and...

πŸ“’ PhD Studentship Opportunity at UCL
Interested in AI, NLP, and health? We’re recruiting a PhD student for TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using NLP
Open to home& overseas applicants
Deadline: Mon 26 Jan 2026 www.postgraduatestudentships.co.uk/opportunity/...

07.01.2026 14:41 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Also everyone needs a statistician!

26.12.2025 17:53 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

23rd!

23.12.2025 15:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It will probably think I am 400 years old!

20.12.2025 10:55 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

option 3 is definitely the one to go with!

08.12.2025 09:18 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
tools for symptoms of depression among young adults (18 to 25 years old) in East Asia and the Pacific. A total of
22 studies with 24,069 participants were included, covering both clinical and non-clinical populations. Nine selfadministered
screening tools were identified, with Patient Health Questionnaire-9 (PHQ-9), Patient Health
Questionnaire-2 PHQ-2, and Centre for Epidemiological Studies Depression (CES-D) being the most frequently
studied. PHQ-9 demonstrated moderate to excellent internal consistency reliability, with Cronbach’s alpha
ranging from 0.67 to 0.92, and a pooled AUC of 0.86, indicating strong screening accuracy. PHQ-2, showed an
Area Under the Curve (AUC) of 0.85, high sensitivity (0.96), and moderate specificity (0.80). CES-D exhibited an
AUC of 0.87, good sensitivity (0.81), and specificity (0.78), with high heterogeneity (IΒ² = 74.70 %–86.69 %). The
meta-analysis revealed substantial variability in sensitivity and specificity across settings, with differences in
study methodologies, cutoff scores, and reference standards contributing to high heterogeneity. Additionally,
95.5 % of studies had a moderate risk of bias in patient selection, affecting generalizability. Despite these limitations,
PHQ-9, PHQ-2, and CES-D remain valuable tools for identifying symptoms of depression among young
adults. The accessibility, ease of administration, and strong psychometric properties of these tests support their
continued use in resource-limited settings, though standardization of methodologies and expanded regional
validation are needed to improve screening accuracy and applicability.

tools for symptoms of depression among young adults (18 to 25 years old) in East Asia and the Pacific. A total of 22 studies with 24,069 participants were included, covering both clinical and non-clinical populations. Nine selfadministered screening tools were identified, with Patient Health Questionnaire-9 (PHQ-9), Patient Health Questionnaire-2 PHQ-2, and Centre for Epidemiological Studies Depression (CES-D) being the most frequently studied. PHQ-9 demonstrated moderate to excellent internal consistency reliability, with Cronbach’s alpha ranging from 0.67 to 0.92, and a pooled AUC of 0.86, indicating strong screening accuracy. PHQ-2, showed an Area Under the Curve (AUC) of 0.85, high sensitivity (0.96), and moderate specificity (0.80). CES-D exhibited an AUC of 0.87, good sensitivity (0.81), and specificity (0.78), with high heterogeneity (IΒ² = 74.70 %–86.69 %). The meta-analysis revealed substantial variability in sensitivity and specificity across settings, with differences in study methodologies, cutoff scores, and reference standards contributing to high heterogeneity. Additionally, 95.5 % of studies had a moderate risk of bias in patient selection, affecting generalizability. Despite these limitations, PHQ-9, PHQ-2, and CES-D remain valuable tools for identifying symptoms of depression among young adults. The accessibility, ease of administration, and strong psychometric properties of these tests support their continued use in resource-limited settings, though standardization of methodologies and expanded regional validation are needed to improve screening accuracy and applicability.

Validated self-administered screening tools to identify depression among young adults (18 to 25-years-old) in East Asia and the Pacific Region low-and-middle income countries (LMICs): A systematic review by my PhD student Dennis Dantic. https//www.science... @ucl-primarycare.bsky.social

26.11.2025 08:55 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

Blackpool North railway station

16.11.2025 14:26 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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a picture of a graduation cap and tassel with the words congrats you did it ALT: a picture of a graduation cap and tassel with the words congrats you did it

πŸŽ‰ Big congrats to Tas Rookes for passing her PhD viva with flying colours!
🧠 Thesis: Improving engagement in health promotion for older adults with mild cognitive impairment
πŸ‘ Supervised by Professor Kate Walters, Louise Marston, Rachael Frost, Megan Armstrong & Yolanda Barrado-MartΓ­n

04.11.2025 16:16 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

We're excited to share our latest work on estimands in clinical trials!

πŸ“„ Estimating treatment effects in trials with outcome data truncated by death: A case study on aligning estimators with estimands.

πŸ”— Read the full paper: journals.sagepub.com/doi/10.1177/...

27.10.2025 14:42 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Apply to work with me and a great team at @uclpsychiatry.bsky.social to do some exciting research using electronic health records! The position is funded for 19 months in the first instance and you’ll be joining a fascinating NIHR project: www.ucl.ac.uk/work-at-ucl/...

17.10.2025 08:40 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Background
Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population.
Aim
To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI.
Design
State-of-the art review
Method
Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure.
Results
From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing.
Conclusion
There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.

Background Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population. Aim To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI. Design State-of-the art review Method Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure. Results From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing. Conclusion There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.

Evidence for health promotion interventions to improve cognitive and physical functioning outcomes in older adults with MCI: A state-of-the-art review www.sciencedirect.com/science/arti... @ucl-caps.bsky.social @ucl-primarycare.bsky.social @drmegs.bsky.social @tasminrookes.bsky.social

07.10.2025 18:26 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Swallowing prehabilitation for people with head and neck cancer: a pilot cluster-randomised feasibility trial of the SIP SMART intervention Objectives To assess the feasibility of delivering the swallowing prehabilitation intervention known as Swallowing Intervention Package: Self-Monitoring, Assessment and Rehabilitation Training (SIP SM...

πŸ“’ New Publication Alert
Congratulations to @Roganie Govender and the entire team on their latest publication! A fantastic achievement!
@ucl-primarycare.bsky.social
bmjopen.bmj.com/content/15/9...

26.09.2025 17:05 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Insult to Muppets and Sesame Street characters.

23.09.2025 18:25 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Every data point tells a story.

Statisticians ensure those stories are heardβ€”spotting safety concerns, reducing bias, and ensuring ethical outcomes in clinical trials.

πŸ”— ukcrc-ctu.org.uk

#Statistics #UKCTUNetwork #WorldPatientSafetyDay2025

17.09.2025 08:47 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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I have just been bought this!

12.09.2025 12:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It is towards the end of our protocol templates...

12.09.2025 09:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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πŸ“’ New dataset drop!
The BRHS @ucl-brhs.bsky.social is now available via @ukdataservice.bsky.social πŸŽ‰
πŸ”— ukdataservice.ac.uk
7,735 men tracked over 50 years = goldmine for research on heart health, ageing & behaviour.
Prof. Wannamethee: β€œUnparalleled insights into ageing & heart health.”

04.09.2025 10:03 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Some on the Sainsbury's website...though not the Taste the Difference, with alcohol one yet.

I might need to go pudding shopping in the name of research.

03.09.2025 18:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

In other news, I finished my last Christmas pudding from last Christmas this week.

03.09.2025 18:39 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Some Christmas products in Morrisons, but do not think there is cake yet.

03.09.2025 18:38 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The colour matches Mr Bump!

15.08.2025 11:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Figure.  SPIRIT 2025 Diagram of the Schedule of Enrollment, Interventions, and Assessments

Figure. SPIRIT 2025 Diagram of the Schedule of Enrollment, Interventions, and Assessments

πŸ“Œ The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research.

ja.ma/4fzMVZS

10.08.2025 16:00 πŸ‘ 30 πŸ” 20 πŸ’¬ 0 πŸ“Œ 2
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COVID-19 and the Physio4FMD trial: Impact, mitigating strategies and analysis plans Functional motor disorder (FMD) is a common cause of disabling neurological symptoms such as weakness and tremor. Physio4FMD is a pragmatic, multicent…

Analysis plan for the main trial analysis paper - published because COVID-19 intervened with the trial and we changed some of the analyses due to that: COVID-19 and the Physio4FMD trial: Impact, mitigating strategies and analysis plans www.sciencedirect.com/science/arti...

31.07.2025 18:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0