Craig Kaplan

Yes. Just percentiled.

grinding your beans #notcoffee

Truth

My brother, we had to explain a 1/3 pound burger was bigger than a quarter pound burger and still failed

I feel like I would say no?

That center is such a delight

Yeah

Today was my best chance at 990s so far and I blew it on 4. Nothing matters

Yes and no. They’ve done R56 before. But last year there were some of these done by GM and it was specifically to get some PIs eligible for MIRA

Answer a fundamental question of existence or admit the help page on my website is alive

Why isn’t the PA AG doing this? (We know why- but why don’t you let the people know how useless he is?)

The other account blew the description

43

Correlation is not causation 🪦

Cryo-EM maps of human DNA polymerase ε should be reevaluated in light of its unexpected behavior in vitro pubmed.ncbi.nlm.nih.gov/41790928/ #cryoEM

And exactly what you say- they have strong investigators that stayed in R01 pool instead of converting to MIRA, potentially due to 50% effort requirement on MIRA, but are in deep trouble because R01 pool reduced from 20-23% funding to 6-7%. They like had to do this to protect MIRA assurances

I think they are paying attention to at risk and yes I suspect that the pickups in second decile are single grant individuals. Note that many of these may also be two year R01s- funded to likely enable those individuals to be eligible for MIRA

It is not and it shifted ground greatly on R01s (even in 2024) from their historically stable levels- applications were dropping for years but funding rate was level, until 2024 where it took big hit, and then even greater last year.

My estimate is from NIGMS data for R01s. Applications are dropping but funded applications dropping much faster. I am waiting for official numbers. GM had to basically do a rug pull on R01s to save R35s, where they made explicit assurances to PIs as part of the 50% effort and no other apps deal

We are waiting for the break down by mech, and total application numbers, but this graph was based specifically on on R01s/R37s (but not R35s). Back of envelope says NIGMS funded about 7% of R01 applications. So 23.2% in 2023, 14.4% in 2024, to ~7% in 2025. Disaster.

He is a menace

That is my personal fave because we all just gravitated to it naturally as wow this is a stunner- and it felt nice that they had that success because for sure they were just a quality band that I am sure had to just grind all the time

that station played Something to Say, Scotty's Lament, Stone Cold Yesterday, Get a Gun, Over There, and the singles from Ring (I feel you will like all of these)

They have a lot of bangers - from their early albums to one that had a little bit of a hit in the UK ('74-'75 from album Ring). (my modern rock station in SLC Utah growing up played them)

just a square of a single color hahaha I am laughing so hard

Yes, I think he's just a podcaster/grifter now but maybe he goes back just to fill up his resentment tank from getting dirty looks and hearing people whispering behind his back.

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

Author also dug up what looks like an astroturf group that praised him- without saying who the group was.

I do not like the use of "divisive" as it makes his damage seem like a discussion point, but the verb is a relief