Ryan MacDonald

Muller glia (green) regulate local retinoic acid signalling to specialise photoreceptor outer segments (magenta)for high acuity visual function

Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. www.biorxiv.org/content/10.6.... We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity visual function.

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

Hi all, we got a grant for a cool project that will follow up of our paper published a few months ago (see below). We will explore how light acts as a morphogen to instruct PCP. If you are looking for a postdoc position and interested in this topic, please reach out!

#ZebrafishCareers 🇬🇧 (Postdoc) #killifish

Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...

I'm supporting Your Columbia! Your Columbia is your opportunity to be a part of the unparalleled research, education, and clinical care that takes place every day at Columbia University Irving Medical Center. It’s a potent and imp...

My lab studies mechanisms of pediatric glaucoma and the development of tissues affected (Schlemm's canal and trabecular meshwork). I am getting creative with fundraising because, well... So if you know someone who might be interested in funding our work: joinus.cuimc.columbia.edu/index.cfm?fu...

#ZebrafishCareers 🇬🇧 (Postdoc) #killifish

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...

First post on this platform is to announce that our preprint is posted to bioRxiv:

bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...

Sorry we’ve never tried cultured organs either.