In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/...
#Hematopoiesis
In this review we discuss our current understanding of how the diversity, maintenance, and function of the heterogeneous memory B cell compartment are shaped by the past and present ‘experiences’ of the individual cells that comprise it.
www.nature.com/articles/s41...
Plasma cells are the immune system’s antibody factories, producing the molecules that protect us after infection or vaccination. They originate from B cell. Yet how B cells make the switch to become plasma cells—and which genes control this transition—isn’t known.
Researchers from the lab of
A huge thank you to the fantastic facilities at the IMP Vienna @impvienna.bsky.social and the Vienna Biocenter for their support!!
Our work is the result of a wonderful collaboration between the Meinrad Busslinger lab, with its B cell expertise, and the Johannes Zuber lab, leaders in CRISPR/Cas9 screens.
Congratulations and many thanks to all authors!!! Markus Schäfer, Marina Rončević (@Helmholtz Munich), Rene Rauschmeier, Markus Jaritz, Tanja Schwickert, Sun Qiong, Andrea Pauli, Johannes Zuber and Meinrad Busslinger!!!
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!
https://rupress.org/jem/article/223/3/e20250594/281445/In-vivo-CRISPR-Cas9-screens-identify-new
Plasma cells are the immune system’s antibody factories, and they originate from B-cells.
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
In @jem.org, @lesly-calderon.bsky.social et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...
Congratulations and many thanks to all authors!!! Markus Schäfer, Marina Rončević (Helmholtz Munich), Rene Rauschmeier, Markus Jaritz, Tanja Schwickert, Sun Qiong, Andrea Pauli, Johannes Zuber and Meinrad Busslinger!!!
