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Mathieu Quesnel-Vallières

@rna-ken

Cancer, immunotherapy & RNA splicing researcher Assistant Professor, Department of Immunology and Cell Biology, Université de Sherbrooke https://mqvlab.com

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29.09.2023
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Latest posts by Mathieu Quesnel-Vallières @rna-ken

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Most people have never heard of cholangiocarcinoma, yet it’s the 2nd most common liver cancer. Awareness isn’t just important, it’s life-changing. Knowledge leads to early detection, research, and hope. Let’s make CCA known. Join us for #WorldCCADay tomorrow, February 19. 🌍

18.02.2026 20:01 👍 0 🔁 2 💬 0 📌 0

Very cool. This has got to be the simplest Figure 1 a Nature paper has seen since 1991.

28.01.2026 01:27 👍 1 🔁 1 💬 1 📌 0
Assistant Professor - Virology Assistant Professor - Virology

Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.

15.01.2026 20:04 👍 22 🔁 50 💬 1 📌 3

Yet another layer to add to the already complex world of gene regulation.

08.01.2026 19:39 👍 0 🔁 0 💬 0 📌 0
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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria This study introduces CRASP-seq, an RNA-coupled CRISPR screening platform designed to systematically identify regulatory factors and domains of alternative pre-mRNA splicing. Using this technology, ZNF207 is identified as a bona fide splicing regulator through its interaction with U1 snRNP components. ZNF207 modulates aberrant LMNA splicing, a critical event linked to progeria.

Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:

30.12.2025 16:19 👍 15 🔁 5 💬 0 📌 2

Tenure-track position opening in plant molecular biology at wonderful @usherbrooke.bsky.social.

Only 10 more days to apply:

06.01.2026 04:23 👍 1 🔁 1 💬 0 📌 0
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Portrait de laboratoire - Pr Mathieu Quesnel-Vallières | Faculté de médecine et des sciences de la santé – Université de Sherbrooke Et si l’ARN était la clé pour vaincre le cancer?   Découvrez comment le laboratoire du professeur Mathieu Quesnel-Vallières repousse les limites de la recherche.  🔬 Mathieu Quesnel-Vallières | Dépar...

Petit portrait de notre laboratoire avec les contributions de Nassima Bouzidi, étudiante au doctorat, et Tony-Carlo Blanchette, stagiaire au 1er cycle.

Merci à la Faculté de médecine et des sciences de la santé de @usherbrooke.bsky.social et au Centre de recherche du CHUS!

05.01.2026 17:23 👍 0 🔁 0 💬 0 📌 0
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Launch of new Canada Impact+ Research Training Awards As announced in Budget 2025 -

Canada is launching a new funding program for PhD students and postdoctoral scientists.

Reach out to me if you are interested in studying gene regulation, RNA splicing and/or cancer immunotherapy using computational and/or experimental approaches.

#PhD #Postdoc

19.12.2025 20:18 👍 7 🔁 4 💬 0 📌 1
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Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668 The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!

09.12.2025 18:11 👍 69 🔁 58 💬 0 📌 1
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Less is more: academic publishing needs ‘radical change,’ Cambridge press report concludes Academic publishing needs “renewed focus and collective action” to embrace new approaches and ensure the future of the industry, concludes a report from Cambridge University Press, released last we…

“We fundamentally believe that publishing less – but better – is essential for the health of the entire research system worldwide,” the authors of the report state.

21.10.2025 19:11 👍 90 🔁 32 💬 0 📌 9

Open rank tenure-track position in comp bio at the University of Montreal. Great environment, great position. @futurepislack.bsky.social

medecine.umontreal.ca/wp-content/u...

03.10.2025 21:24 👍 4 🔁 11 💬 1 📌 1

Last night, Al-Helou hospital in #Gaza City, supported by MSF, sustained severe collateral damage from nearby attacks. This came despite multiple assurances from Israeli forces that the hospital was not in danger.

29.09.2025 18:48 👍 121 🔁 77 💬 3 📌 3
Cornell University, Molecular Biology & Genetics Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US

We have an open Assistant Professor position in Evolutionary Cell and Molecular Biology in the @weillinstitute.bsky.social at Cornell University. academicjobsonline.org/ajo/jobs/30607

22.09.2025 15:25 👍 35 🔁 50 💬 0 📌 0

I switched to Inkscape a few years ago. It's great.

11.09.2025 15:17 👍 1 🔁 0 💬 0 📌 0
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Group Leader - EMBL Hamburg Are you ready to lead groundbreaking research in Infection Biochemistry? Join us at EMBL Hamburg! We are recruiting outstanding scientists to establish independent research groups tackling fundamental...

Pls share: Distributing this advertisement from EMBL for a group leader position at their Hamburg, Germany site:

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

02.09.2025 15:00 👍 2 🔁 10 💬 0 📌 0

I just described one of my aims as being "functional with translational undercurrents" in a grant that I'm writing, as if I were describing a fine wine, and for this sole reason I already consider this application to be successful.

31.08.2025 21:23 👍 7 🔁 0 💬 1 📌 0
Image of Toronto

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

28.08.2025 06:34 👍 133 🔁 169 💬 0 📌 8
Lab members Emma, Mathieu, Nassima and Léo pose dressed up and wearing fabulous fashion accessories in front of a glittering curtain.

Lab members Emma, Mathieu, Nassima and Léo pose dressed up and wearing fabulous fashion accessories in front of a glittering curtain.

My fabulous lab is raising funds to support the @src-crs.bsky.social and the Université de Sherbrooke Cancer Research Institute.

Join us on September 13 or consider donating to our team to help us design the next generation of cancer treatments!

recherche-cancer-research.crs-src.ca/goto/MQV_lab

27.08.2025 16:51 👍 5 🔁 1 💬 0 📌 0
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RNA is far more than a messenger.

Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.

But predicting #RNA structure from sequence is still extremely difficult.

In our recently published paper in @narjournal.bsky.social we present a way forward.

🧵 ⤵️

25.08.2025 03:01 👍 57 🔁 18 💬 1 📌 3
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

07.07.2025 14:28 👍 158 🔁 66 💬 4 📌 5
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Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

01.07.2025 17:14 👍 24 🔁 30 💬 1 📌 4
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🔊 Meet Mathieu Quesnel Vallières @rna-ken.bsky.social : Using transcriptomic analyses to find cancer immunotherapy targets, he’s bringing his expertise to @usherbrooke.bsky.social , supported by D2R’s New Faculty Start-Up program

🔗Learn more: buff.ly/laJgUJ3

#ResearcherSpotlight #RNAResearch

27.05.2025 13:15 👍 3 🔁 2 💬 0 📌 0
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dFORCE provides a revised timeline for mRNA synthesis wherein cleavage, termination, and m6A
deposition occur earlier than, or at least partially decoupled from, the bulk of splicing in thousands of genes

29.04.2025 13:56 👍 5 🔁 2 💬 1 📌 0
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A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation - Nature Communications Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function a...

Thrilled to share my 1st PhD paper exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬(and first post at @bsky.app :)

Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu

Details below:

09.05.2025 09:35 👍 29 🔁 7 💬 2 📌 1

Hey Canadian scientists who haven't voted yet, here's a comparison of the costed platforms as they pertain to science prepared by the Canadian Society of Molecular Biosciences: csmb-scbm.ca/wp-content/u...

23.04.2025 15:06 👍 22 🔁 15 💬 1 📌 1

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”

https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

19.04.2025 12:12 👍 177 🔁 47 💬 7 📌 10
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Canada's political leaders must stand up for humanity.

Do you agree?

Retweet this tile to let them know. 🇨🇦

Read our full statement here: www.doctorswithoutborders.ca/msf-to-canad... #cdnpoli

17.04.2025 16:00 👍 319 🔁 110 💬 8 📌 2

Rare personal post to express how grateful I am for my collaborators and colleagues, for all the people around me willing to help, and how lucky I am to have this job.

10.04.2025 23:37 👍 2 🔁 0 💬 0 📌 0

Special thanks to Dr. Alexis Gonneaud and Dr. Jean-Philippe Babeu for their help and enthusiasm getting this project started.

25.03.2025 17:32 👍 0 🔁 0 💬 0 📌 0

Thank you @c17council.bsky.social, Childhood Cancer Canada and Sarcoma Research Canada for funding our project aiming to develop targeted immunotherapy for children with high-risk sarcoma.

Very excited to team up with Dr. Stéphanie Vairy to push this research forward!
#childhoodcancerresearch

25.03.2025 17:31 👍 2 🔁 1 💬 1 📌 0