Heli Jeskanen

The protective PLCG2 variants delay Alzheimer's disease onset age in APOE ϵ4 carriers https://www.medrxiv.org/content/10.1101/2025.09.22.25336304v1

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions - Journal of Neuroinflammation Background Phospholipase C gamma 2, proline 522 to arginine (PLCγ2-P522R) is a protective variant that reduces the risk of Alzheimer’s disease (AD). Recently, it was shown to mitigate β-amyloid pathol...

Exciting news! Our study ”The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions” is now published in the Journal of Neuroinflammation! 🧠✨

Check it out 🤓👇🏻

jneuroinflammation.biomedcentral.com/articles/10....