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Alexander Stein

@alexsteinresearch

Cancer Genomics | Somatic Evolution | Math Bio DE -> CH -> UK -> BE Always happy to chat about science!

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19.11.2024
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Latest posts by Alexander Stein @alexsteinresearch

It was fun working on this project, and I am grateful to my collaborators Kate Bostock, Ramanarayanan Kizhuttel, Maciej Bak and especially my Master Thesis supervisor and mentor @robjohnnoble.bsky.social

07.03.2026 09:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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On the expansion and evolution of a master’s project Academics often lament that hardly any master’s projects – even the best ones – get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tel...

And if you are curious about the β€žbehind the sceneβ€œ story of the paper, from conception to publication, have a look at this blog post: communities.springernature.com/posts/on-the...

07.03.2026 09:09 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Mathematical modelling predicts selective sweeps are restricted to early stages of tumour growth mathematical-oncology.org

You can find some highlights of the paper in this blog post: mathematical-oncology.org/blog/selecti...

07.03.2026 09:09 πŸ‘ 0 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Selective sweep probabilities in spatially expanding populations - Nature Communications In this study, the authors use mathematical modelling and analysis to understand how mutations spread through populations that are expanding in space. The results shed light on the evolution of biolog...

Our paper "Selective sweep probabilities in spatially expanding populations" is out in Nature Communications!

Our work extends the theory of population genetics and contributes to our understanding of cancer evolution.

doi.org/10.1038/s414...

07.03.2026 09:09 πŸ‘ 13 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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On the expansion and evolution of a master’s project Academics often lament that hardly any master’s projects – even the best ones – get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tel...

Academics often lament that hardly any master’s projects get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tell how one master’s project was, through persistent teamwork, finally carried over the finish line: go.nature.com/4aKs7N3

04.03.2026 14:24 πŸ‘ 24 πŸ” 9 πŸ’¬ 1 πŸ“Œ 1

An incredible opportunity for early career researchers - Imperial's Faculty of Medicine is hiring 20 Assistant Professors!

13.02.2026 11:28 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London on FindAPhD.com PhD Project - Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London, listed on FindAPhD.com

If you’re interested in machine learning and mathematical modelling, we’re recruiting a PhD student to develop new methods for studying cancer evolution at
@imperialimmuno.bsky.social

www.findaphd.com/phds/project...

13.02.2026 13:18 πŸ‘ 8 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1
Screenshot of Job Ad

Screenshot of Job Ad

EMBL site in Heidelberg

EMBL site in Heidelberg

Zurich, incl. a bit of UZH/USZ

Zurich, incl. a bit of UZH/USZ

Job offer: PhD-level biostatistician with ML&omics experience to work on prediction models for CAR T cell therapy, in an exciting clinical trial - spatial omics - data science consortium (LOOP/INTeRCePT3.0 centered in Zurich; this position in Heidelberg)

embl.wd103.myworkdayjobs.com/en-GB/EMBL/j...

13.02.2026 08:41 πŸ‘ 10 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Postdoctoral Researcher in Cancer Genomics - VIB Chart tumour evolution using cutting-edge long-read and single-cell multiomics Who we are The Integrative Cancer Genomics lab (Jonas Demeulemeester) is embedded within the VIB – KU Leuven Center for ...

🧬 We're hiring a postdoc!

Come chart somatic evolution with us using cutting-edge long-read & single-cell tech πŸ”¬

Computational bio background + love for complex cancer genomics = perfect fit

πŸ“ Leuven, Belgium πŸ“§ jobs.vib.be/j/129915/

#postdoc #genomics #hiring

09.02.2026 11:39 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

15.10.2025 15:53 πŸ‘ 162 πŸ” 211 πŸ’¬ 1 πŸ“Œ 5
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Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD:
jobs.icr.ac.uk/vacancies/14...

It's bench-to-bedside research, translating biology of pre-cancer evolution.

Funded by @bowelcanceruk.bsky.social

19.01.2026 09:11 πŸ‘ 12 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1
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Postdoctoral Researcher in Cancer Genomics - VIB Chart tumour evolution using cutting-edge long-read and single-cell multiomics Who we are The Integrative Cancer Genomics lab (Jonas Demeulemeester) is embedded within the VIB – KU Leuven Center for ...

My supervisor, Jonas Demeulemeester (@jdemeul.bsky.social), is hiring a Postdoc to study Cancer Genomics at the VIB-KU Leuven Center for Cancer Biology: jobso.id/pbgr

Cool projects, great team, and super working environment in general! Check it out!

09.01.2026 18:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?

Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

29.09.2025 07:03 πŸ‘ 45 πŸ” 35 πŸ’¬ 0 πŸ“Œ 0
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Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!

24.09.2025 03:32 πŸ‘ 13 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
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Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

10.09.2025 15:21 πŸ‘ 91 πŸ” 39 πŸ’¬ 7 πŸ“Œ 2

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. https://www.biorxiv.org/content/10.1101/2025.09.08.674950v1

09.09.2025 07:35 πŸ‘ 6 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
Darwin's famous sketch of a rooted tree, representing speciation

Darwin's famous sketch of a rooted tree, representing speciation

New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.

Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14

arxiv.org/abs/2507.08615

14.07.2025 09:42 πŸ‘ 6 πŸ” 3 πŸ’¬ 3 πŸ“Œ 0
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In #GENETICS, @alexsteinresearch.bsky.social‬ and @benjaminwerner.bsky.social‬ present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/AE4sLUH

15.07.2025 20:02 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

Interested in population genetics of cancer?

If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!

29.05.2025 15:22 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Lecturer in Applied Mathematics at City St George’s, University of London Apply for the Lecturer in Applied Mathematics role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

My department is hiring! Permanent faculty job (research + teaching) in applied maths. Mathematical biology would be highly appropriate. We're a friendly department in a large university in central London, recently merged with a big medical school. Apply by 1st June. www.jobs.ac.uk/job/DMY889/l...

06.05.2025 09:42 πŸ‘ 12 πŸ” 17 πŸ’¬ 2 πŸ“Œ 3

Thank you David @cancerevo.org and Simone @zaccasimo.bsky.social for building my PhD viva panel! I enjoyed the discussions and appreciate your time and effort to assess my PhD.

And heartfelt thank you Ben @benjaminwerner.bsky.social and Katerina for guiding me through this PhD journey!

21.03.2025 10:44 πŸ‘ 6 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Congratulations to a successful viva Dr. @alexsteinresearch.bsky.social

Many thanks to @cancerevo.org and @zaccasimo.bsky.social to be examiners!

20.03.2025 22:22 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Tenure-Track Assistant Professor for Mathematical or Computational Ecology (80-100%) - Bern, Canton of Bern (CH) job with Institut fΓΌr Γ–kologie und Evolution | 12834542 The Department of Biology at the University of Bern announces a vacancy for a Tenure-Track Assistant Professor to lead a new Division of Mathematic...

The University of Bern is looking for a Tenure Track Assistant Professor in Mathematical or Computational Biology: www.nature.com/naturecareer...

03.01.2025 13:26 πŸ‘ 12 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

Congrats to all of you! πŸ₯³

14.12.2024 11:37 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

28.11.2024 09:40 πŸ‘ 32 πŸ” 28 πŸ’¬ 0 πŸ“Œ 1
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πŸ“New Author's summary about

"Complexity-stability relationships in competitive disordered dynamical system" O Mazzarisi, M Smerlak

and

"Diversity begets stability: Sublinear growth and competitive coexistence across ecosystems" I Hatton, O Mazzarisi, A Altieri, M Smerlak

27.11.2024 08:42 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Somatic mutation and selection at epidemiological scale As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

20.11.2024 14:27 πŸ‘ 88 πŸ” 38 πŸ’¬ 2 πŸ“Œ 5
β€ͺOn the patterns of genetic intra-tumour heterogeneity before and after treatment‬ β€ͺA Stein, B Werner‬, β€ͺbioRxiv, 2024‬

Alex just dropped his magnus opus on BioRxiv

scholar.google.com/citations?vi...

19.11.2024 10:59 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0