In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome.
We just published a preprint describing how we are tackling this problem. /1
Thanks Mike… bring on the Liverpool Half next weekend. What am I like, eh?!!
Yes. And we had chips to complete “all the food groups”!! 🍟
Done!! #CambridgeHalfMarathon 🥂
Recent university graduates entering a tough jobs market have spoken of the brutal interest rates on the loans they took out to fund their degree from The Bank of Mum and Dad.
From the new Private Eye, out now.
A Texas biotech company is trying to bring mammoths and other extinct creatures back to life. The science is as intriguing as the ethical questions are thorny.
Interesting, if wildly optimistic, article about the future of DSP's.
open.substack.com/pub/joelgouv...
Two decades of iPSCs - a timely overview from Shinya Yamanaka.
www.cell.com/cell-stem-ce...
FT comments section this morning - saying what everyone else is thinking, right?
"Make people dependent enough, and then make it shitty"
Still giggling at this hilarious video from the Norwegian Consumer Council "A Day in the Life of an Ensh*ttificator" which seems a perfect embodiment of Silicon Valley and tech generally these days
www.youtube.com/watch?v=T4Up...
Bob Power, Legendary Music Engineer And Producer, Passes Away At 74
RIP to the legendary music engineer and producer, Bob Power.
Power contributed to landmark albums such as A Tribe Called Quest’s 'The Low End Theory,' D’Angelo’s 'Brown Sugar,' Erykah Badu’s 'Baduizm,' The Roots' 'Things Fall Apart,' and many more.
Our cat, lying on a blanket on a lime green sofa. She’s twisted so that her front paws are pointed in one direction, her back paws the other. And we love her for it
Yeah… Monday..!
Here's a 'fun' stat for you...
At this stage of the 2003/04 season (ALL competitions), Wenger's Invincibles:
42 games
31 wins
7 draws
4 defeats
__
2025/26 Arsenal side:
44 games
34 wins
7 draws
3 defeats
Denmark becomes first country in the European Union to eliminate mother-to-child transmission of HIV and syphilis. This is testament to universal health access and a functioning public health system.
The US recorded 4000 cases of congenital syphilis in 2024.
www.who.int/news/item/27...
What was the #Biodiversity #Genomics #Europe project all about? The full details presented here: riojournal.com/article/1875...
We've wrapped up the BGE project, but there will be many more outputs to come, as well as the lasting legacy of reference data, processes, standards, and much much more!
That's how prohibition is. You say you'll stop the boats and you end up stopping the nurses.
Illumina's TruPath to compete with long read methods? How will it compare to Hi-C methods for FFPE SNV analysis?
www.genomeweb.com/sequencing/i...
Another splendid 'debunk' from @monkemma.bsky.social. It's hard to overestimate just how much work it takes to excavate, accurately and in detail, the layers of half-truth, falsity, misinterpretation etc. of these kinds of stories: monkdebunks.substack.com/p/the-500k-b...
142,000 participants!
The largest randomized trial of a multi-cancer early detection (MCED) test failed its primary endpoint
genomeweb.com/cancer/grail...
Had the enrollment been risk-based instead of age 50, it would likely have been very positive.
No country "needs" immigration - in the same way that no country "needs" trade... But the countries that chose it grew larger, richer and more dynamic."
Another excellent piece by @akoustov.bsky.social
alexanderkustov.substack.com/p/western-co...
Mom of 7-year-old hospitalized with brain swelling from measles: I still wouldn't have given my son the vaccine
Ethan's parents decided not to immunize him against measles as they did with his three brothers. Three out of four of them contracted measles. Still, despite Ethan's ordeal, his mom stands by their decision "We're not blaming God for this," said 35- year-old Kristina. "Yes, it hurts, of course it hurts. But God has chosen Ethan for a reason. God is doing something, and we're gonna glorify his name regardless. "And we wouldn't change it any other way" the mom continued. "If I knew this could be the outcome, I still wouldn't have given my son the vaccine."
I've interviewed moms like this—moms who won't vaccinate, reassuring themselves that if their child dies, it's God's will.
It's almost impossible to change their minds, because they believe God won't let them into heaven if they vaccinate their kids, since vaccinating means not trusting God's plan.
We are gods and they are the @thedears.bsky.social.
Such a great night at the Portland Arms #Cambridge last night
5,000-Year-Old Bacteria Strain Found in Ice Cave Resistant to 10 Common Antibiotics
www.discovermagazine.com/5-000-year-o...
![SCENE: A PASSPORT CONTROL GATE, IN THE SKY, ON A CLOUD. THE PASSPORT CONTROL GATE HAS ‘CORPOREAL REALM’ WRITTEN ON IT.
PASSPORT CONTROL OFFICIAL: Passport please, sir.
OFFICIAL [LOOKING AT PASSPORT]: Ah - the famous Dr Jenner!
EDWARD JENNER, A FLOATING GHOST IN EDWARDIAN GARB: Indeed, haha
OFFICIAL: And what's the purpose of your visit to the corporeal realm, Dr Jenner?
EDWARD JENNER: Haunting.
OFFICIAL: Oh lovely. Anyone nice?
EDWARD JENNER: Just a little tour of some anti-vaxxers.
OFFICIAL: Wonderful. I hear Andrew Wakefield’s bedroom is just •perfect• at this time of year.
EDWARD JENNER: It is! I spent last summer standing by his bed, calling him a c--.
OFFICIAL: Lucky yooou…
OFFICIAL [LOOKING AT DOCUMENTS]: Oh... oh dear...
EDWARD JENNER: Is everything OK?
OFFICIAL: I’m afraid your card says you haven’t had the required stupidity vaccination for your trip.
EDWARD JENNER: Oh dear!
OFFICIAL: It’s fine - we can do it here…
Just read this anti-vax tweet by Jim Carrey
EDWARD JENNER [reading a smartphone]: Egads!
[Ends]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:4m3we4apbjayclzcnhwe3pfp/bafkreibelysv45nptkn3fzrjup3xl5tx5pcmnzvmcbpim72tul5dvyf2w4)
SCENE: A PASSPORT CONTROL GATE, IN THE SKY, ON A CLOUD. THE PASSPORT CONTROL GATE HAS ‘CORPOREAL REALM’ WRITTEN ON IT. PASSPORT CONTROL OFFICIAL: Passport please, sir. OFFICIAL [LOOKING AT PASSPORT]: Ah - the famous Dr Jenner! EDWARD JENNER, A FLOATING GHOST IN EDWARDIAN GARB: Indeed, haha OFFICIAL: And what's the purpose of your visit to the corporeal realm, Dr Jenner? EDWARD JENNER: Haunting. OFFICIAL: Oh lovely. Anyone nice? EDWARD JENNER: Just a little tour of some anti-vaxxers. OFFICIAL: Wonderful. I hear Andrew Wakefield’s bedroom is just •perfect• at this time of year. EDWARD JENNER: It is! I spent last summer standing by his bed, calling him a c--. OFFICIAL: Lucky yooou… OFFICIAL [LOOKING AT DOCUMENTS]: Oh... oh dear... EDWARD JENNER: Is everything OK? OFFICIAL: I’m afraid your card says you haven’t had the required stupidity vaccination for your trip. EDWARD JENNER: Oh dear! OFFICIAL: It’s fine - we can do it here… Just read this anti-vax tweet by Jim Carrey EDWARD JENNER [reading a smartphone]: Egads! [Ends]
From 2019
Staggering that 24% of voters in this advanced country continue to believe in a bunch of entitled bigots with unworkable policies, whose very ideas put us in the abject chaos we are in. Truly God awful idiots, and I make no apology for saying that.
Just for fun, here's the drum break (Melvin Bliss' Synthetic Substitution). Because its a banger!
youtu.be/aPw0ua8U6fc?...
Simon Harris RIP.
A real deal hip hop & dance music pioneer in the UK, as a DJ, producer, remixer, promoter & label boss.
Music of Life really was our Def Jam.
Thank you Simon, rest well 🙏🏻 🕊️
