Wafik S. El-Deiry, MD, PhD, FACP

Breakthrough Discovery Could Make Pancreatic Cancer Respond to Chemo Again A newly discovered gene switch may help turn chemotherapy-resistant pancreatic cancer into a treatable disease.

Breakthrough Discovery Could Make Pancreatic Cancer Respond to Chemo Again

scitechdaily.com/breakthrough...

Pleased to see most recent world, national and university rankings in molecular biology according to research.com @BrownPathology @BrownUniversity @BrownMedicine @BrownUCancer #LegorretaCancerCenter #eldeirylab

What’s so religious about opposing vaccines? What, exactly, is “religious” about refusing vaccination?

Good read👇

“What’s so religious about opposing vaccines?”

www.statnews.com/2026/03/06/r...

NIH reneges on recognizing union for early-career researchers The biomedical research agency says trainees in its labs are not “employees”

NIH reneges on recognizing union for early-career researchers

The biomedical research agency says trainees in its labs are not “employees”

www.science.org/content/arti...

Great presentation today at #LegorretaCancerCenter Cancer Bio Program meeting by @KMDaileyPhD,
Assistant Professor, Biomedical & Pharmaceutical Sciences, URI
Faculty Scholar, RI-INBRE on “Changing the Paradigm: Developing Clostridium novyi-NT as an Intravenous Pancreatic Cancer
Therapeutic.”

In his own words, Dr. Robert Weinberg @MIT explains the iconic EMT figure during his seminar @BrownUniversity this morning. This was inaugural presentation in Hallmarks of Cancer Series organized by @SenduraiMani #LegorretaCancerCenter

#legorretacancercenter | Wafik S. El-Deiry, MD, PhD, FACP This morning we were so fortunate to have a seminar presentation by Professor Robert Weinberg from Massachusetts Institute of Technology as the inaugural talk in a new series on the Hallmarks of Cance...

We were fortunate to have presentation by Robert Weinberg @MIT in new series on Hallmarks of Cancer organized by @SenduraiMani

Weinberg taught about metastatic cancer, EMT, stem cells, plasticity & tumor dormancy, he inspired, gave advice, & answered questions.
www.linkedin.com/posts/wafike...

Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer Integrating microphysiological and spatial profiling, Campisi et al. identify tumor vasculature as a major barrier to NK cell recruitment in SCLC. Activating vascular STING signaling restores NK cell ...

Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer

www.cell.com/cancer-cell/...

Vinay Prasad, key Makary ally and a focus of controversy at the FDA, is leaving the agency Prasad has been involved in several controversial decisions related to rare disease treatments.

Vinay Prasad, key Makary ally and a focus of controversy at the FDA, is leaving the agency

www.statnews.com/2026/03/06/f...

Exclusive | FDA’s Controversial Vaccines Chief Will Leave the Agency Dr. Vinay Prasad will depart in April, after a year leading the division that approves vaccines and biotech drugs.

FDA's Controversial Vaccines Chief Will Leave the Agency

Dr. Vinay Prasad will depart in April, after a year leading the division that approves vaccines and biotech drugs

www.wsj.com/health/healt...

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

www.cell.com/molecular-ce...

Two decades of induced pluripotent stem cell research: From discovery to diverse applications Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in repro...

Two decades of induced pluripotent stem cell research: From discovery to diverse applications
Shinya Yamanaka

www.cell.com/cell-stem-ce...

Serotonin Modulates Lineage Plasticity in Neuroendocrine Prostate Cancer via Epigenetic Reprogramming

aacrjournals.org/cancerdiscov...

A closed tumor-immune-brain circuit in cancer cachexia Cancer-associated cachexia is a complex metabolic syndrome leading to sustained body weight loss and tissue wasting. In this issue of Cancer Cell, Shi et al. identify a novel GDF15-driven tumor-immune...

A closed tumor-immune-brain circuit in cancer cachexia involving GDF15

www.cell.com/cancer-cell/...

Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity

www.nature.com/articles/s41...

Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models NK cell therapy lacks sustained efficacy in treating tumors. Wang and colleagues developed a pluripotent stem cell-derived induced NK lineage-committed progenitor (iNKP) cell therapy, which showed per...

Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models

www.cell.com/cell-stem-ce...

5th Anniversary Thematic Collection: Manipulating DNA Repair and the DNA Damage Response to Improve Cancer Therapy url:https://academic.oup.com/narcancer/pages/manipulating-dna-repair @emgsus.bsky.social @weldeiry.bsky.social

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding - Nature Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding

www.nature.com/articles/s41...

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer - Nature Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer

www.nature.com/articles/s41...

A July 4 reminder: Ukrainian and Iranian physician scientists need our support during these extraordinary times - The Cancer Letter I have no doubt that our professional associations in cancer research and oncology and our NCI in the U.S. care about the plight of cancer scientists and oncologists who have been displaced due to war...

It’s almost 3 years later and things are even worse sadly. May the resilience of the human spirit and the goodness in humanity prevail.

A July 4 reminder: Ukrainian and Iranian physician scientists need our support during these extraordinary times

cancerletter.com/guest-editor...

I came across this image today hanging on a wall while visiting with a radiologist to review a scan.

Good conversation with colleagues Drs. @mhadfield30 & Ari Pelcovits about initiative in training & career development they provide to Brown students, residents & fellows interested in biomed sciences including hem-onc. We discussed efforts to integrate with #LegorretaCancerCenter education/training.

Special Edition: Why Can’t We Cure Cancer? A National Conversation | Full CUOMO Show 2/27 YouTube video by NewsNation

Interesting conversation that leaves me hopeful for a better day in dealing with cancer whether early or advanced.

Special Edition: Why Can’t We Cure Cancer? A National Conversation | Full CUOMO Show 2/27

youtu.be/L6gbF1kuHiQ

Distinct prophage infections in colorectal cancer-associated Bacteroides fragilis

www.nature.com/articles/s43...

Are obesity drugs causing a severe complication? What the science says The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

Are obesity drugs causing a severe complication? What the science says

The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

www.nature.com/articles/d41...

Thank you @SenJackReed for your unwavering support of medical research. Research brings hope for a better future including for Rhode Islanders.

Glutathione is critical for NK cell-mediated immunity Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...

Glutathione is critical for NK cell-mediated immunity

www.cell.com/cell-reports...

Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible Tumor suppressor TP53 is an important gene in human cancer because it is mutated in the majority of tumors, leading to loss-of-function or gain-of-function phenotypes. Mutated TP53 acts like an oncogene, driving cancer progression and causing poor ...

Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible

pmc.ncbi.nlm.nih.gov/articles/PMC...

A disease model resource reveals core principles of tissue-specific cancer evolution - Nature The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

A disease model resource reveals core principles of tissue-specific cancer evolution

www.nature.com/articles/s41...

The day after the historic blizzard that shattered all previous state records with >37 inches of snow.