Corey Griffith

Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox-inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved ...

doi.org/10.1002/jimd...

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells - The EMBO Journal Oxidative stress is a major driver of cardiovascular disease; however, the fast changes in cellular metabolism caused by short-lived reactive oxygen species (ROS) remain ill-defined. Here, we characte...

link.springer.com/article/10.1...

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

Great work from @philouail.bsky.social 🙌

#xcms now fully integrated into @bioconductor.bsky.social 💪

👉 #metabolomics #MassSpectrometry #rstats

Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase in conditions of low NAD+.

Nature research paper: A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia

go.nature.com/45Eb8te

Frontiers | Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders Zellweger spectrum disorders (ZSDs) are rare autosomal recessive conditions belonging to the larger group of peroxisome biogenesis disorders. The most preval...

doi.org/10.3389/fnmo...

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://

www.sciencedirect.com/science/article/abs/pii/S1097276525008196

Congratulations @bensahralab.bsky.social !!

Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data - Nature Communications Mass spectrometry-based lipidomics and metabolomics generate large, complex datasets requiring effective analysis. Here, authors review key statistical and visualization methods alongside widely used ...

Great resource: doi.org/10.1038/s41467-025-63751-1

Pathophysiology of the Neutropenia of GSDIb and G6PC3 Deficiency: Origin, Metabolism and Elimination of 1,5‐Anhydroglucitol Neutropenia in Glycogen Storage Disease Type Ib (GSDIb) and G6PC3 deficiency results from defects in metabolite repair, leading to the accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P). Trea...

Still one of my favorite metabolite repair stories.

doi.org/10.1002/jimd...

Exciting to see IC-MS getting more attention. It really does have excellent separation and coverage for central carbon metabolites, including those pesky sugar phosphates.

Check out our article in this issue on the metabolite repair role of CLYBL!

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

Some really nice points outlining the misuse of metabolomics in pathway analysis.

To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.

doi.org/10.1038/s422...

Thanks for sharing!

Thank you!!

Give it a read! Free access: rdcu.be/eebr8

CLYBL averts vitamin B12 depletion by repairing malyl-CoA - Nature Chemical Biology CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to t...

Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪

A Bleak Future? Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science

I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience

theanalyticalscientist.com/business-edu...

Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:

The HuMet Repository - Watching human metabolism at work

www.sciencedirect.com/science/arti...

All data provided in an interactive repository:

humet.org

The T32 training grant supported the interdisciplinary and multi-department design of the UC Riverside Environmental Toxicology Graduate Program. Funding from it gave me valuable time to focus on research and I am eternally grateful for the impact it has had on my career.

Thank you @jeremymberg.bsky.social for highlighting the special importance of T32s. This allowed me to launch an interdisciplinary chemistry/biology interface (CBI) graduate program at UCB in early 2000s. For the first time, due to this funding, chem PhD students were able to do rotations. 1/n

the rich and powerful want to destroy biomedical science, like they wanted to destroy climate science, and before that tobacco science and before that asbestos science -- because science and universities are an independent source of truth that can reduce the power and money of oligarchs.

Mechanisms of metabolism-coupled protein modifications - Nature Chemical Biology This Perspective highlights how metabolic states regulate diverse protein modifications that affect physiology. In addition, the roles of subcellular localization of metabolic enzymes and the importan...

Neat perspective on the connection between metabolism & PTMs.

Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.

www.nature.com/articles/s41...

Why aren’t they taking the fired federal workers who are sharing their heartbreaking stories—the ones that Musk says were being paid to do nothing—and making them famous? The cancer researcher on the verge of a breakthrough? The park ranger in Yosemite who won’t be there to conduct rescues and save lives? The air traffic controller who can speak to the connection between understaffing and recent plane crashes? Is it even safe to fly in Trump’s America? The Democrats should be amplifying these folks—writing op-eds about them, refusing to go on camera without sharing their spotlight, pressuring their IG influencers to raise them up—but instead, we learn their stories from Reddit. As Moira Donegan wrote in The Guardian, “Why are the Democrats so spineless?”

I've noted some of the procedural things Democrats could be doing in Congress, but this point from @edgeofsports.bsky.social's great piece in the Nation deserves emphasis.

This is basic politics, and it's baffling that every Democrat isn't doing it every day.

www.thenation.com/article/poli...

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠

sciencehomecoming.com

Yes, and this is super-important.

People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!

The job of all scientists 🧪 in this moment should be to get the word out.

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Darby makes this point but I just want to reinforce it: These words are entirely legitimate to discuss science, accurately and correctly. This attack on "DEI" (🙄) is not only an attempt to resegregate science but also an attack on expertise, itself.

Resisting it is a defense of science

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg

Hey Erik! Could you please add me to the Science feed? Thanks for the help! Proof: scholar.google.com/citations?us...