Rare Disease Day was on 28th Feb.
The 2026 Haldane Lecture at Wolfson College, Oxford delivered by Prof. Dame Kay Davies focused on the importance of rare disease research.
It not only reveals fundamental biology but also paves pathways to new therapies (AAVs, gene editing, read through drugs).
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).
A brief 🧵 (carried over from the old place)
📢📢📢Lectureships at Bristol!📢📢📢
We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline.
Great department, great colleagues, great building, great city
Details here:
www.bristol.ac.uk/jobs/find/de...
A brief communiqué on the temporary funding pause recently announced by UKRI detailing a summary of the main changes can now be found on the network website.
www.cilianetwork.org.uk/news/4687/uk...
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
Cool new story which discovers a novel role for the multiciliogenesis-linked transcription factor McIdas (aka Multicilin) in centriole duplication.
link.springer.com/article/10.1...
At long last, the Chlamy chloroplast ribosome hat 🎩 (now renamed the arm 💪) is here to say hello👋! We first spotted this extended structure in green algae a decade ago, and @florentwaltz.bsky.social did beautiful work bringing it into focus! #CryoEM ❄️ #TeamTomo 🔬 #PlantScience 🌾 #ProtistsOnSky 🧪
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
Incredible new work on ciliary axoneme assembly spearheaded by @helenfoster.bsky.social (#NewPI) from the @gaiapigino.bsky.social. Like all good science, answers many questions & opens up many new ones!
Kudos to the entire team for this important advance in cilia biology. Lovely animation!
Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome. http://dlvr.it/TQnW4n
Last couple spots remaining for the Craniofacial GRC in sunny CA! Looks to be a full house, with a great set of up-and-coming #craniofacial biologists spanning evo/devo, genetics, multiomics all the way to stem cells, engineering and repair. @brugmannlab.bsky.social www.grc.org/craniofacial...
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
'We have become familiar with videos of people we do not know getting detained & ripped from families and beaten by agents whose salaries we pay. As social media does its work putting pieces together about each unfolding tragedy, more of us will realize that those pieces belong to someone we know' 🥹
Model of FLA and FLABP assembly into the FAZ. FLAs (yellow) and FLABPs (green) traffic through the Golgi (1). Vesicle trafficking (2) ensures delivery of FLAs and FLABPS to the flagellar pocket (FP), where an unknown sorting mechanism guides FLAs and FLABPs towards different pathways (3), although it is possible this sorting mechanism occurs before the flagellar pocket, with distinct docking sites for the different proteins. FLAs move towards the cell body membrane (4), while FLABPs cross the transition zone and collarette (5) and move along the flagellum membrane (6). Around the flagellar pocket collar (FP collar; red), FLAs and FLABPs interact (7), enabling integration of the FLA–FLABP pair into the elongating new FAZ (8). BB, basal body. Based on Absalon et al., 2008.
Laryssa de Liz, Jack Sunter and colleagues find that trypanosome bloodstream-specific flagellum attachment proteins can mediate attachment in an insect surface coat environment.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Transport motor loss and hyperactivation cause axonal microtubule bundle damage mediated by inferred ROS dyshomeostasis upon motor loss, and through ROS-independent mechanisms, likely through increased mechanical load, upon motor hyperactivation
www.manchester.ac.uk/about/news/r...
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
A cilium of a fixed RPE-1 cell, expanded and imaged with #3DSTED and #FLEXPOSURE adaptive illumination. CEP164 🟥 (STAR RED), acetylated tubulin+CCDC41 🟦 (STAR ORANGE).
Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR.
#ExM #superresolution #fluorescencefriday
New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...
Bummed to miss #ASCB this year (one of my fav meetings), but the lab is well represented!
Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Congrats to the whole team!
Add our first pre-print to your reading list?
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!
To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
So proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
