Sushil Dubey

My PhD work showed that vimentin is not only a passive marker of EMT, but plays an active role in collective migration, controlling the mechanics of epithelial leader cells. I am grateful to my supervisors, Rene-Marc & Benoit Ladoux, as well as to all the co-authors.
www.biorxiv.org/content/10.6...

Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM

Wondering how to control the environment of cells?

Check out this insightful #EpithelialMechanics thread by @lhinderling.bsky.social 👇

Finally you managed to get paneer☺️

Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...

To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...

The picture shows the official flyer with more information about the conference, for example the scientific organizing committee and the invited speakers.

Exploring the Frontiers of #Mechanobiology

Mechanobiology Conference III, organized by Prof. @bladoux.bsky.social ( #MPZPM), takes place July 6–12, 2025 in Vietnam. Topics include cell signaling, biomaterials & more.

📅 Deadlines: Abstracts – Apr 30 | Reg – Jun 6

👉 icisequynhon.com/conferences/...

We are excited to share our recent preprint on how tissue spreading guides extracellular matrix changes during early morphogenesis @gurdoninstitute.bsky.social

🌿✨ Calling all mechanobiologists, bioengineers, and curious minds! ✨🌿
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...

Congratulations, 🎉 Priti!

Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...

Fascinating! Congratulations 🎉

Cell and Tissue Dynamics (Wickström)

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Tissues are dynamic and investigating cellular mechanical states can be crucial for understanding biological processes. But how to do it?

We are @andreasschoenit.bsky.social and @luanger.bsky.social from @bladoux.bsky.social / @rmmege.bsky.social lab highlighting ways to assess tissue stresses.

Happy to share our new publication in @naturephysics.bsky.social on life and death of eliminated cells! Great collaboration between our CAM team and Doostmohammadi's. Special congrats @lakshmib02.bsky.social and Siavash Monfared! 🎉
www.nature.com/articles/s41...

We have an exciting line-up of speakers for our third Mechanobiology conference in Vietnam from July 6 - 12, 2025.
icisequynhon.com/conferences/...

This work wouldn’t have been possible without the all the amazing collaborators @yoannletoquin.bsky.social, Aleksandra, Christophe Marcelle, and Amin. A huge thanks to @bladoux.bsky.social for mentoring and shaping the research direction.

4. Moreover, extracellular matrix (ECM) plays a key role! As myoblasts self-organize, the ECM mirrors their alignment, reinforcing stable defects hence mechanical stress patterns. This coupling between cells and ECM boosts myotube growth.

3. Myoblasts fusion is enriched at topological defects mainly at +1/2, why so? Since these defects acts a hotspots of compressive stress, concentrating at head of +1/2 defects, therefore, forcing fusion to localize around these defects.

2. Myoblast and myotube patterning follows physical rules-as they differentiate to form multinucleated myotubes, they self-organize, a typical of nematic systems.

1. How do biomechanics shape muscle growth💪? Our new study (Mechanical stresses govern myoblast fusion and myotube growth) dives into the role of mechanical stresses in myogenesis. We explored the biophysics behind muscle formation!

My first post on #bluesky and it's going to be a special one!
Our study investigates the role of biomechanics in muscle fusion and differentiation...🧵👇
www.biorxiv.org/content/10.1...