Di Antonio Research Group

⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis

Ravi Gupta is looking directly at the camera, the lab background is blurred. He is wearing a dark jacket and blue open necked shirt.

Head and shoulders shot of Marco di Antonio. He is looking directly at the camera with his shoulders slightly angled. He is wearing a pale open necked shirt.

Impressive number of Lister community members in
@clarivate.com's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows

🥇 Marco di Antonio @diantoniogroup.bsky.social
🥇 Ravi Gupta

Congrats on your highly influential research 👏

clarivate.com/highly-cited...

📣 Announcement 📣

We are delighted to announce that the 2025 Supramolecular Chemistry Award 🏆 goes to Prof Dr Job Boekhoven from TU Munich.

Congratulations, Job! @boekhovenlab.bsky.social

Thanks @cellpress.bsky.social for generously sponsoring the award!

(1/3)

It was a pleasure @mcgalanlab.bsky.social and congratulations again to Nina for the lovely viva. Next time hopefully catch up in person!

Well done guys!

As promised, we run the town and gown 10k! In the photos are group members @rogerrubiosanchez.bsky.social Juliette Bucci, Brian Ng, Cathrine Fan, Sebastian Krauss and Lorenzo (the old one). Thanks to all who supported us with donations to @mdukcharity.bsky.social

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

With motor neurone disease (MND, aka ALS) hitting the headlines, here's a story about how two #ListerFellows @patanilab.bsky.social and @diantoniogroup.bsky.social teamed up to investigate how RNA might start aggregations and trigger disease.
lister-institute.org.uk/two-lister-f...

SportsGiving - Entry: Lorenzo Di Michele Lorenzo Di Michele is fundraising for charity. Visit their fundraising page to sponsor them online now!

Hey! Some group members and I are running a 10k race in Cambridge this Sunday, and raining some funds for @mdukcharity.bsky.social

Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social

sportsgiving.co.uk/sponsorship/...

Have fun guys and leave nothing behind! push push push!

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇

www.imperial.ac.uk/jobs/search-...

John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!

Thank you @beckyneuro.bsky.social @therad-lab.bsky.social and @thav-lab.bsky.social for kicking off our annual meeting with such inspiring insights from your research. Impressive examples of career-long commitment to a cause, opportunistic curiosity and always aspiration for clinical application 👏

Marco Di Antonio - his fantastic science is always challenging dogma, but first a bit about Italy ❤️ 🤌🤌🤌

@diantoniogroup.bsky.social

I would say that the expert on intrinsically toxic sequences is @costerlab.bsky.social

One of which is the HoD :)

CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress - Nature Communications In this study, the authors demonstrate that cleavage under targets and tagmentation (CUT&Tag) can be employed to map G-quadruplexes (G4s) in Mycobacterium tuberculosis, which may serve as pot...

Proud to share our latest research in #NatureCommunication on #Gquadruplexes in #M_Tuberculosis as a new defense mechanism against oxidation
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis

Please share - this year's #ListerPrize is open for applications for another month!

🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...

🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei, the ca...

Happy to share our latest preprint describing the first genome-wide mapping of G4s in T.Brucei, led by the amazing Ludovica Monti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with G4-ligands.
www.biorxiv.org/content/10.1...

Babies from three people's DNA prevents heriditary disease The method was pioneered by UK scientists to overcome devastating, sometimes fatal inherited diseases.

BBC News - Babies made using three people's DNA are born free of hereditary disease
www.bbc.com/news/article...

Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology!
@rscchembio.rsc.org
@mikeboothlab.bsky.social

📣NAR Breakthrough Article!📣

✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊

📖 doi.org/10.1093/nar/...

#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics

Outstanding work, well done Mike it was an amazing day!

Thank you for your constant support!
@thelisterinstitute.bsky.social

Very pleased to see that The Observer has written a piece to cover our recent work in Genome Biology applied to ovarian cancer chemoresistance. Link below 👇👇👇
@theobserveruk.bsky.social
@imperialcollegeldn.bsky.social
@imperialchemistry.bsky.social

observer.co.uk/news/nationa...

Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬
@diantoniogroup.bsky.social