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Xin Xiang

@xianglab

dynein, dynactin, Lis1, kinesin-1, Aspergillus nidulans as a genetic system. Opinions are my own.

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13.11.2024
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Latest posts by Xin Xiang @xianglab

Congratulations to Prasanna Satpute-Krishnan (@pskcellbio.bsky.social)
for winning the USU Henry C. Wu Award for Excellence in Basic Science Research!

13.02.2026 15:55 πŸ‘ 7 πŸ” 2 πŸ’¬ 1 πŸ“Œ 1
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From MBoC… Cells move cargo in clever ways. John Salogiannis (University of Vermont) reveals how the protein AcbdA helps peroxisomes hitchhike on early endosomesβ€”connecting intracellular transport with fatty acid metabolism. www.molbiolcell.org/doi/full/10....

31.12.2025 16:05 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.

14.12.2025 16:28 πŸ‘ 26 πŸ” 32 πŸ’¬ 2 πŸ“Œ 2

#CellBio2025

This Wednesday, Dec 10 at 9:00 AM in Room 122

Please add it to your schedule!

06.12.2025 12:46 πŸ‘ 6 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Zo: The intelligent cloud computer We're on a mission to make the internet wild and free again. Build the most powerful personal software, and host anything – with all your context. Store your files, connect your tools, then ask AI to ...

The zo computer allows one to try different AI models www.zo.computer (they normally give the same answers but some are better organized) (in setting, choose my AI, then it should allow you to choose)

04.12.2025 11:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Give the laurels to the one who earned them.

A thread that aims to attribute credits to the originators of important β€˜firsts’

This is on the making. Please contribute to accurate historical records with comments and reading recommendations

πŸ§΅πŸ‘‡

04.12.2025 06:25 πŸ‘ 19 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0

Without these possibly impossible mutants, it is hard to falsify that LLPS may play a role somewhere in the process just as more specific protein-protein interactions. Both could be necessary (neither is sufficient). I have never worked on LLPS. These discussions are very helpful! Thanks!

30.11.2025 16:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I enjoyed reading the paper! The mutant data is convincing that LLPS can’t be the sole driver of protein localization in cells. It would be even better to obtain mutations that disrupt LLPS and show no effect on cellular localization, but this must be hard given the nature of the interactions.

30.11.2025 15:45 πŸ‘ 0 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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My postdoctoral mentor N. Ronald Morris passed away on Nov. 20, 2025. He was 92. I am forever grateful to his mentorship and his visionary use of Aspergillus nidulans as a genetic system to explore fundamental questions in cell biology. www.hillsboroughfuneralhome.com/obituaries/D...

29.11.2025 15:18 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

I had fun checking out the endomap site (endomap.hms.harvard.edu/network). Surprisingly, PRPF40A (pre-mRNA splicing, Huntingtin-interacting, Aspergillus homolog Prp40A involved in cytoplasmic dynein function) connects to axonemal dynein light intermediate chain polypeptide, which is interesting!

02.06.2025 14:30 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

www.dha.mil/News/2025/05...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!

journals.plos.org/plosbiology/...

24.05.2025 13:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Thank you Ferdos!

29.04.2025 22:38 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organ...

Preprint from our lab is out! We identified a peroxisome-localized acyl-coA binding protein AcbdA - that regulates peroxisome movement. www.biorxiv.org/content/10.1.... Congratulations to members of my lab and the Christensen lab
@christensenlab.bsky.social www.biorxiv.org/content/10.1...

24.04.2025 18:50 πŸ‘ 9 πŸ” 5 πŸ’¬ 0 πŸ“Œ 2

Beautiful work! Aside from the motor cooperation theme, this paper shows an insightful structure of the FHF complex (initially isolated by Wade Harper lab at Harvard. Xu et al 2008 MBoC). The structure contains FTS, the C-terminal part of Hook3 and FHIP1B. What a journey! Congrats to Abid Ali et al!

27.04.2025 11:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!

13.04.2025 16:36 πŸ‘ 88 πŸ” 79 πŸ’¬ 5 πŸ“Œ 8

Thank you so much Prasanna!

11.04.2025 08:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Happy to share this short spotlight piece kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... published online by @cp-trendscellbio.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social

10.04.2025 23:31 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Wow! Congratulations!

20.03.2025 20:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

LC8 moonlighting (most likely) in channels. Nice work!

18.03.2025 11:16 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

An interesting read. Neil Gow just gave a fantastic talk at the #ecfg17 on fungal cell wall components- on mannose polymers that can either be a flag or a mask for different immune cells. The part on the malaria parasite is also fascinating.

09.03.2025 12:20 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Redirecting

Just learned about this amazing work! doi.org/10.1016/j.cub.2024.12.041

07.03.2025 11:15 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...

21.02.2025 12:56 πŸ‘ 18 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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The actin module of endocytic internalization in Aspergillus nidulans: a critical role of the WISH/DIP/SPIN90 family protein Dip1 Using FPs fused with actin or its fiduciary probes Lifeact, Chromobody and Tractin, we studied, by time-resolved microscopy, the actin module of endocytosis in Aspergillus nidulans. F-actin probes eff...

our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...

16.02.2025 19:58 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Fungal impacts on Earth’s ecosystems - Nature This Review delves into the fungal kingdom, exploring the relationships among fungi, animals, plants and the environment, and investigating both the threats posed by fungi and their potential benefits...

Review in Nature

Case et al.
Fungal impacts on Earth’s ecosystems

www.nature.com/articles/s41...

06.02.2025 12:33 πŸ‘ 47 πŸ” 19 πŸ’¬ 1 πŸ“Œ 1

Interesting! I guess they may still have it to get rid of lactic acid produced in muscle.

06.02.2025 23:26 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Dr. Samara Reck-Peterson Named Chair of the Department of Biochemistry and Biophysics at Weill Cornell Medicine The newly configured department marshals biochemists, biophysicists and experts in protein engineering and imaging to drive discoveries in the basic mechanisms of cell function.

I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...

31.01.2025 23:38 πŸ‘ 170 πŸ” 13 πŸ’¬ 20 πŸ“Œ 3
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Integrating cell and planetary scales to address climate resilience The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

The deadline to attend the β€œIntegrating cell and planetary scales to address climate resilience” EMBO meeting is Feb 1st! We are bringing together scientists, funders, and policy makers. Join us for this exciting meeting: meetings.embo.org/event/25-cli...

20.01.2025 17:04 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

This is such a sad news! I remember talking to him at meetings many years ago and learning about the Rab11-centrosome connection…

18.01.2025 13:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Graphical abstract of the Organelle Profiling paper, showing the workflow:
Endogenously tagged organelle library;
Native IP proteomics;
Data-driven graph clustering;
resulting in a subcellular proteome map with
more than 7,600 proteins localized across 19 subcellular compartments.

Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 πŸ§ͺ

14.01.2025 16:02 πŸ‘ 193 πŸ” 59 πŸ’¬ 7 πŸ“Œ 2
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I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.

We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy

I started this w/ Alex Lichius years ago, tip of the 🧊!

03.01.2025 11:28 πŸ‘ 16 πŸ” 7 πŸ’¬ 6 πŸ“Œ 0