Leon Tejwani, PhD

thanks for sharing!

🙋‍♂️

if there is still space, possible to add me? thanks!

Lysosomes cell autonomously regulate myeloid cell states and immune responses https://www.biorxiv.org/content/10.1101/2024.11.11.623074v1 Myeloid cells maintain tissue homeostasis via the recognition, engulfment, and lysosomal clearance o

Lysosomes cell autonomously regulate myeloid cell states and immune responses https://www.biorxiv.org/content/10.1101/2024.11.11.623074v1

Reach out with feedback, suggestions, and questions-- would love to chat more! And if you're in the Boston area, would love to meet and discuss over coffee~

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model Lysosomal dysfunction is causally linked to neurodegeneration in many lysosomal storage disorders (LSDs) and is associated with various age-related neurodegenerative diseases, but there is limited und...

Also, be sure to check out one of the other companion papers from Chris Balak and Chris Glass, who found similar epigenetic and transcriptional responses in microglia from a mouse model of MPS-IIIA, a lysosomal storage disorder: www.biorxiv.org/content/10.1...

If you have time to read through our manuscript, we'd love to hear your thoughts and answer any questions you might have. We appreciate any and all (constructive) feedback and suggestions for how we can convince you further that lysosomal dysfunction can drive neuroinflammation!

I feel lucky to have had the chance to work with such a great team on a project that (in my opinion) has implications that can fundamentally change the way people think about myeloid cell responses across many contexts by bridging the fields of lysosomal biology and immunology.

A huge thanks to my amazing former colleagues at
Denali and collaborators from the Glass lab at UC San Diego, who collectively enabled literally endless possibilities for this project.

Here, we report a fundamental link between lysosomal homeostasis and myeloid cell (microglia and macrophage) states and functions, especially as it relates to progranulin deficiency (and frontotemporal dementia + neuronal ceroid lipofuscinosis).

Lysosomes cell autonomously regulate myeloid cell states and immune responses Myeloid cells maintain tissue homeostasis via the recognition, engulfment, and lysosomal clearance of dying cells and cellular debris, which is often accompanied by changes from homeostatic to reactiv...

Really excited to share the pre-print of my postdoc work from Gil Di Paolo’s group @ Denali Therapeutics: www.biorxiv.org/content/10.1...