Ines Pineda Torra

Congratulations! Amazing achievement!

Headshots of the five physicians we are highlighting for World Lupus Day. Anne Troldborg, MD, PhD, Elizabeth Jury, PhD, Inés Pineda-Torra, PhD, Akiko Iwasaki, PhD and Ruth McPherson, MD, PhD, FRCPC.

💜 On #WorldLupusDay, let’s raise awareness: Women aged 35-44 with lupus are 50x more likely to have a heart attack than those without.

Shout-out to the women advancing research on lupus & heart health: 👇

@virusesimmunity.bsky.social @inespinedatorra.bsky.social

#CardioSky #MedSky

Why is this conference unique?
📌Focus on students/postdocs
📌All introduce themselves: 1 min pitch+ 1 slide
📌18 short talks from selected abstracts
📌4 tutorial lunches with speakers
📌3 poster sessions with discussions
📌Beach workshops 🏖️☀️

Register:
functionalgenomics2025.febsevents.org

It’s that time of the year again! Send your abstracts for a new edition of our @febs course! #metabolism #genomics
Deadline is coming up!

Great discussions as usual with @jury-lab.bsky.social and @georgearobinson.bsky.social !

Amazing!!! So well deserved! Certainly celebrations are in order!

Very interesting study!

We do Research in beautiful Barcelona studying Nuclear Receptors from a Structural & Functional perspective. We love collaborating with groups Worldwide that share our Passion for Science 🚀✨️🪐

Simgle combined measure of hsCRP, LDL & Lp(a) among initially healthy U.S. women was predictive of incident CV events during a 30-yr period

#CardioSky #MedSky #NEJM
@drmarthagulati.bsky.social @erinmichos.bsky.social @michaeldshapiro.bsky.social @drlipid.bsky.social
www.nejm.org/doi/full/10....

Obesity, Diabetes & Metabolism Research Join the conversation

@stephenorahilly.bsky.social welcome! Find many in our community here via the starter pack. One of the great advantages of this site over the other 😀

go.bsky.app/NRoqMvp

The Human Cell Atlas: towards a first draft atlas In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body.

A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪

On the pathogenesis of obesity: causal models and missing pieces of the puzzle Nature Metabolism - This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis...

Views about the causes of obesity have polarised. Characterised by low carb and energy balance models. Last year NovoNordisk invited the protagonists of these models to Copenhagen to discuss commonalities and differences. The resultant paper has now been published in Nature Metabolism rdcu.be/dZryb

Signal 4 nutrients in directing T cell activation. (A) Overview of Signals 1 (TCR binding to antigen presented on MHC molecules), 2 (co-stimulation by CD28), 3 (cytokine signals), and 4 (nutrients) that drive T cell immunity. Signal 4 is mediated through a three-tiered process composed of nutrient transport, sensing, and signal transduction. Signals 1–3 can augment Signal 4 by promoting the expression of nutrient transporters, while Signal 4 also interplays with Signals 1–3, for example, by shaping signaling and metabolic events. Integration of Signals 1–4 results in metabolic reprogramming, associated with increased mTORC1 signaling, c-MYC activity, and activation of biosynthesis pathways and cellular bioenergetics, altogether driving T cell activation. (B) Glucose and amino acid uptake into T cells, mediated by membrane transporters, promotes mTORC1 activation and metabolic reprogramming. Sestrins, CASTOR1, and SAMTOR represent cytosolic sensors of amino acids. Leucine and arginine respectively bind to and sequester Sestrins and CASTOR1 from GATOR2, relieving their suppressive effects on GATOR2, thereby allowing GATOR2 to promote mTORC1 activation (via inhibiting GATOR1). SAMTOR senses the methionine metabolite S-adenosylmethionine (SAM). SAM binding to SAMTOR disrupts SAMTOR–GATOR1 complex formation, thereby inhibiting the ability of GATOR1 to negatively regulate mTORC1 activation. SLC38A9 senses arginine in the lysosome, and both SLC38A9 and v-ATPase signal the increase in intralysosomal amino acid concentrations to promote mTORC1 activation, which may involve controlling the efflux of amino acids from the lysosome. Arginine also promotes mTORC1 signaling by regulating TSC–RHEB signaling. Glutamine signals through ADP ribosylation factor 1 (ARF-1) to promote mTORC1. Asparagine is sensed by LCK to promote TCR-mediated PI3K–Akt signaling. The SWI/SNF complex (including SMARCB1) inhibits gene expression of Castor1 and thereby enhances mTORC1 activity. CCDC101-assoc…

#MedSky🧪 #ImmunoSky summarize the impacts of nutrients and associated factors (e.g., nutrient-derived metabolic intermediates and extracellular metabolites) on #Tcell activation, differentiation & function & the underlying mechanisms
rupress.org/jem/article/...

Una de las cosas que me preocupa es que los científicos nos estamos viniendo aquí en masa. Es eso dar rienda suelta a la desinformación?🤔
#DebateAbierto

In addition to science expect a lot of beautiful sunsets!

Hello Bluesky! I’m a scientist and group leader in a biomedical research center now in Sevilla, Spain, working on cardiovascular disease in women and the impact of menopause.
Posts will cover a range of those topics.
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