Karolina Kuodyte

I’m very excited to share that our paper has been recently published in Cell Stem Cell! 🎉 🧫

In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.

doi.org/10.1016/j.st...

Making human pancreatic acinar cells Dresden researchers develop novel methods to create acinar cells, which are involved in the formation of pancreatic cancer.

The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.

Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...

Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9