M. Concepción Gimeno

Great work, congratulations team!

Infographic illustrating a European patent application for "Copper-based chemotherapeutics." A central copper atom (Cu) is shown with connecting lines pointing to three panels representing the treatment targets: Breast Cancer, Cervical Cancer, and Pancreatic Cancer. Each panel depicts the respective organ alongside an icon of a fragmenting tumor, indicating the therapeutic effect.

Big milestone for our team! 🧪 We have officially filed a European patent for our latest advances in copper-based chemotherapeutic agents.

Honored to work alongside @conchitagimeno.bsky.social , Raquel P. Herrera and E. Romanos on this. Thanks for the support! 💸

#Metallodrugs #Cancer

Cover of Journal of Medicinal Chemistry. The artwork illustrates the ViVo temporal modeling framework, showing a blend of advanced statistical data visualizations and biological research elements to represent the reduction of animal usage in drug discovery.

So proud to see our cover of the Journal of Medicinal Chemistry! 🧪🎨

We introduce ViVo, a new framework for temporal modeling designed to maximize data quality and minimize animal usage. 📉🐁
@conchitagimeno.bsky.social
Link: pubs.acs.org/doi/10.1021/...

#Science #MedChem #DrugDevelopment #ViVo

ViVo: A Temporal Modeling Framework That Boosts Statistical Power and Minimizes Animal Usage Preclinical tumor studies are often limited by high variability and small-sample sizes, reducing statistical power, and masking treatment effects. We present an exponential framework that estimates tu...

Now #OpenAccess in Journal of Medicinal Chemistry!
We present ViVo: A Temporal Modeling Framework That Boosts Statistical Power and Minimizes Animal Usage | pubs.acs.org/doi/10.1021/...
Congratulations and thanks to @conchitagimeno.bsky.social, R. P. Herrera and E. Romanos 🐁📊💊
#3Rs #oncology

📣Nice collaboration with @conchitagimeno.bsky.social and her group just published in @inorgchemfront.rsc.org where we highlight how strategic ligand design can modulate photophysical responses, advancing the development of next-generation responsive luminescent materials.👇
doi.org/10.1039/D5QI...

Congratulations!

What a fantastic defense by Roberto Berbés, supervised by Conchita Gimeno (@conchitagimeno.bsky.social) and Raquel Herrera. High quality, fresh perspective, and passion for chemistry. Great to see isolda Romero(@unibirmingham.bluesky.uk) and meet David Diaz (@ull.es)

Thank you Dori!

</> For the curious coders out there, here's the GitHub repo:
github.com/gcanudo-barr...
#OpenSource #Code

ViVo: A temporal modeling framework that boosts statistical power and minimizes animal usage Preclinical tumor studies are often limited by high variability and small sample sizes, reducing statistical power and masking treatment effects. We present an exponential framework that estimates tum...

🧬 We just launched 𝐕𝐢𝐕𝐨! An open-source platform for 𝘪𝘯 𝘷𝘪𝘷𝘰 efficacy assays.⁣
Built with automated tumor kinetic analysis to boost preclinical oncology while minimizing animal usage.⁣
📚 Methodology: doi.org/10.1101/2025...
🐁 Try: gcanudo-barreras.github.io/ViVo-Platfor...
⁣
#OpenScience #Oncology

Thank you Angela!

Excellent Start of ISBOMC in Paris! First day featuring many great presentations like the one of @conchitagimeno.bsky.social and get together with former PhDs and friends in organometallic chemistry! Thanks to @gassergroup.bsky.social and @cariouk.bsky.social for the organization!! 🤗🥂

Thank you very much Toni!

Elusive no more: Gold–phosphane tellurides illuminate heavy chalcogen bonding and activation Reporting in Cell Reports Physical Science, Gimeno and co-workers isolate elusive gold–phosphane tellurides and uncover how metal coordination reshapes tellurium bonding, reactivity, and σ-hole-driven...

I was very happy and proud to comment Gimeno's work (@conchitagimeno.bsky.social) in Chem
Elusive no more: Gold–phosphane tellurides illuminate heavy chalcogen bonding and activation: Chem www.cell.com/chem/fulltex...

A researcher giving an oral presentation at the XL Bienal of @rseq-quimica.bsky.social in Bilbao, standing next to a projected slide showing data on light-tracing organometallic drugs.

A researcher giving an oral presentation at the XL Bienal of @rseq-quimica.bsky.social in Bilbao, standing next to a projected slide showing data on light-tracing organometallic drugs.

A researcher giving an oral presentation at the XL Bienal of @rseq-quimica.bsky.social in Bilbao, standing next to a projected slide showing data on light-tracing organometallic drugs.

A researcher giving an oral presentation at the XL Bienal of @rseq-quimica.bsky.social in Bilbao, standing next to a projected slide showing data on light-tracing organometallic drugs.

Excited to share some of our latest work with @conchitagimeno.bsky.social on light-tracing organometallic drugs at the XL Bienal of @rseq-quimica.bsky.social in Bilbao!

At the end of a Golden conference with friends, Sophie Thomas @sophierthomas.bsky.social , Cider 🍺 and Chorizo … 😉😁🥂 @lrraurell.bsky.social @conchitagimeno.bsky.social

Great talk by Prof. Angela Casini at the GOLD 2025 conference 🥳🥳🥰 @medbioinorgchem.bsky.social

Gold Acyclic Diaminocarbene Complexes as Selective and Potent Agents for Multitarget Cancer Therapy Gold acyclic diaminocarbene (ADC) complexes represent a promising, yet underexplored, class of chemotherapeutics. ADCs offer superior flexibility and stronger sigma donation compared with traditional N-heterocyclic carbenes, making them ideal ligands for stable gold-based drugs. In this study, a series of gold ADC complexes were synthesized via the nucleophilic addition of amines to [AuCl(CNCy)], yielding three structural families: gold-chloride-ADC (chiral and achiral), bis(carbene), and thiolate-gold-ADC complexes. Extensive characterization, including X-ray diffraction, revealed noncovalent interactions, such as hydrogen bonding and aurophilic contacts, that significantly shape their molecular architecture. These complexes exhibit potent cytotoxicity (IC50 in submicromolar) against drug-resistant cancer cell lines (A549, HCT116 WT, Jurkat, MiaPaca2), with some showing high selectivity toward cancer cells over healthy lymphocytes (selectivity index up to 74). Mechanistic investigations indicate that they disrupt mitochondrial function, elevate reactive oxygen species (ROS), and, in the case of bis(carbene) species, bind DNA. Apoptosis is induced at low concentrations, while higher doses trigger alternative death pathways. Notably, they also strongly inhibit thioredoxin reductase (TrxR), comparable in potency to auranofin. The combination of ROS induction, DNA interaction, mitochondrial disruption, and TrxR inhibition highlights the multitargeted anticancer potential of gold-ADC complexes and supports their further development as selective and effective chemotherapeutic agents.

Check our last paper about Gold Acyclic Diaminocarbene Complexes as Selective and Potent Agents for Multitarget Cancer Therapy | Inorganic Chemistry pubs.acs.org/doi/10.1021/...

🛠️ Continuing at #LUCESCOSTAction GAM in Zadar: Guillaume Vives (Sorbonne University, FR) on “Switchable Molecular Tweezers as Multifunctional Platforms”! Smart molecular devices for dynamic control and sensing! 🧬🔁 @costprogramme.bsky.social

🧬 Wrapping up the morning session at #LUCESCOSTAction: Sophia Hayes (University of Cyprus, CY) presenting “Thiazole Orange Styryl Derivatives as G-Quadruplex DNA Fluorescent Probes”! Advancing molecular tools for DNA sensing! ✨📚

Congrats!

🔍 Productive afternoon at #LUCESCOSTAction GAM in Zadar!
Parallel meetings of WG1, WG2, and WG3 underway, shaping future directions in luminescent sensing, supramolecular chemistry, and environmental security!
Collaboration drives innovation! 🌍✨ @costprogramme.bsky.social

📢📢The final program for the 2nd LUCES Group Action Meeting (GAM) (April 28–29, 2025, Zadar, Croatia) is now available—featuring an outstanding lineup of speakers!

Thank you Enrique!

Thanks Pepe!

Thanks Laura!

Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies Mitochondria-targeting drugs (mitocans) based on organic cations are emerging as powerful and selective cancer therapeutics. In this study, we have ev…

See our collaborative article on Multimodal antiproliferative effects of oleanolic acid mitocans: In vi... www.sciencedirect.com/science/arti.... Congrats to all involved.

Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance to conventional therapies, leading to poor patient outcomes. This challenges the effi...

Thrilled to share our #JACS paper! Our new Ru(II)-COUBPY photosensitizer (PI >30,000) for hypoxic tumor treatment using red light with in vivo validation!. @gassergroup.bsky.social pubs.acs.org/doi/10.1021/...

Una investigadora zaragozana lidera en París un prometedor proyecto contra el cáncer de ovario El cáncer de ovario es uno de los más mortales debido a su difícil detección temprana

A nice way to celebrate 11F!! Thanks to @aragondigital.bsky.social for giving visibility to this project funded by @frm-officiel.bsky.social and carried out at @gassergroup.bsky.social. 👩‍🔬💉🥼

www.aragondigital.es/articulo/san...

Gold(I) Complexes with Bulky Phosphanes: A Dual Approach to Triplet Harvesting and Hydroamination Catalysis | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Nicasio, Lima, Rodriguez, and co-workers @InorgChem #gold #phosphanes #luminescence #catalysis