Inflammasome Lab

Beyond excited that two of my brilliant students, Kirsten and Manasa, submitted their PhD theses in the last few weeks! Congratulations ladies! The future of science is in great hands. #inflammasomes #PhDone #ProudPI

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Poster deadline is approaching for @keystoneSymposia.bsky.social #InnateImmunity: Diversity in #HostDefense & Disease, this March in Banff! See scholarship, abstract and registration: keysym.us/KSInnateImmune26 #KSInnateImmune26 @jkagan1.bsky.social @brozlab.bsky.social

It's shaping up to be an amazing line up at the Gordon Cell Death meeting! Register now! www.grc.org/cell-death-c...

Congratulations Jakub! So great to see this now in print! 🥳. Beautiful work solving the GBP mystery!

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...

💫 You’re invited - our first event of 2026 is just around the corner! 💫

(1/6)
💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...

Innate Immunity Meeting Promo YouTube video by KeystoneSymposia

A fantastic innate immunity conference coming soon. Join us!
youtu.be/xmQv36uYm7s?...

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Deadlines are approaching for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See key dates: keysym.us/KSInnateImmune26 #KSInnateImmune26

Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!

symposia.smart.org.cn/sym/event/Fu...

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.

uq.wd3.myworkdayjobs.com/en-GB/uqcare...

Congratulations @mitosrus.bsky.social!

So great to see this out Ben, congratulations!

Convergent evolution of scavenger cell development at brain borders - Nature Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells.
www.nature.com/articles/s41...

ARC grant scheme timetable, including open, close and anticipated outcome announcement dates for Expressions Of Interest and full applications, plus rejoinder periods and selection meeting dates.

#ARCschedule Jan26 update

ARC announced huge delays & 3-month announcement windows (used to be 2 weeks).

Delay in months per scheme:
🔹LP25: 1–4
🔹IC/IH26: 1–4
🔹FT26: 1–3
🔹LP26: 2.5–5.5
🔹LE27: 2–5
🔹DE27: 1.5–4.5
🔹DP27: 3–6

Just … appalling. Unworkable.

Data ▶️ docs.google.com/spreadsheets...

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26

Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...

Towards a molecular and structural definition of cell death Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology!
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm

Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...

Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...

New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...

Review @cp-molcell.bsky.social @inflammasomelab.bsky.social
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)

Register now: bit.ly/4iXGqjw

(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open!
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...

So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!

#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience

@nhmrc.bsky.social

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps

go.nature.com/4pxKgV6

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...

#Inflammasome #Inflammation