Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
The registration deadline for this wonderful meeting is approaching! Be sure to reserve your spot before March 10!
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded βSβ compartment
link.springer.com/article/10.1...
Model figure showing EZH2-L50S effect on chromatin and B cell gene expression from https://www.biorxiv.org/content/10.64898/2025.12.08.692979v2.article-metrics.
Updates after feedback, so nowβs the time to advertise! Our work with the late, great Charles Kirkpatrick, a force in Clin. Immunology for 60 yrs. We found that B cell immunodeficient patients of his had a hypomorphic variant in EZH2 caused by a defect in allostery. www.biorxiv.org/content/10.6...
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event thatβs missing? Please reply below
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
Figure depicting the four classes of important questions that frequently arise when using research organisms to study biomedical questions and translating findings to humans. a, How to predict diseaseβgene or functionβgene relationships across species? Diagram depicts genes in each species associating with specific functions, diseases and phenotypes. b, How to identify functionally equivalent molecular components across species? Diagram depicts finding the most equivalent gene, pathway or expression module or phenotype between species. c, How to infer perturbed molecular profiles across species? Diagram depicts gene expression in each species as a result of taking a particular perturbation like a drug. d, How to map equivalent cell types and cell states across species? Diagram depicts alignment of cell types across species. This Perspective comprehensively lays out the landscape of recent and state-of-the-art data-driven strategies, including those that leverage artificial intelligence and machine learning (ML), for answering these questions.
Our Perspective article on Computational Strategies for Cross-Species Knowledge Transfer is now published in @natmethods.nature.com!
This was a collab b/w @krishnanlab.bsky.social & @fishevodevogeno.bsky.social, led by the amazing Hao Yuan @yhbioinfo.bsky.social. π§΅
www.nature.com/articles/s41...
Glad to share our latest work that came out recently. We dive into the mechanisms of how Transcription Factors (TFs) like the nuclear receptor, ERΞ± navigate the genome to find their targets.
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
Excited for this work by Michael Cortazar, an @JagannathanLab Postdoc, to be out as a preprint.
So much hard work went into it, but it was well worth it π€
A thread on our latest paper from the Whitehouse lab
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 Ξ±-satellite HOR variants. www.biorxiv.org/content/10.6...
Our "quantized ratchet" model bridges structural biology (continuous motor movement) with genomics (discrete positioning).
Spearheaded by graduate student Van La, with key contributions from newly minted PhD Abby Trouth and in collaboration with @vram142.bsky.social
5/
The pattern holds everywhere we looked:
βοΈ In vivo = in vitro (Salt Gradient Dialysis)
βοΈ Foreign DNA in yeast
βοΈ Loss of ISWI, Chd1, INO80, RSC
βοΈ Transcription inhibition
βοΈ mouse Embryonic Stem Cells
DNA sequence constrains ALL nucleosome dynamics via ~10 bp periodicity. 4/
Key discovery: When remodelers or RNAPII move nucleosomes, rotational settings DON'T change. Only translational positions shift. 3/
We adapted "multitaper" (from ribosome profiling) to quantify nucleosome rotational positioning strength at SINGLE nucleosome positions genome-wide.
Works on standard MNase-seq, unlocking analysis of hundreds of existing datasets. 2/
Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones)
But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :
www.biorxiv.org/content/10.6...
Calling all archaeal enthusiasts! π¬π₯ From molecular machines to microbial communities, Archaea never fail to surprise us!
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6β10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
New online: Evolution of promoter-proximal pausing enabled a new layer of transcription control
Rotational settings quantize nucleosome movement by chromatin regulators https://www.biorxiv.org/content/10.64898/2025.12.12.693854v1
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID βοΈπͺͺ
Spearheaded β singlehandedly β by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
Excited to share that this work is now published in its final form!
link.springer.com/article/10.1...
Very happy with the final version of this work showing menin-MLL is a vulnerability in liver cancer and an interesting re-localization of NF-Y in response to menin inhibition. Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival: Cell Reports doi.org/10.1016/j.ce...
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Giovana Breda Veronezi, who also earned her PhD this year, was first author on a research article
doi.org/10.1016/j.ce...
πThis Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies!
ποΈRegister here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
