Gene regulatory networks: from correlative models to causal explanations
Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...
New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"
Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?
rdcu.be/e7zx7
09.03.2026 11:30
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Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).
A brief π§΅ (carried over from the old place)
28.02.2026 08:12
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Wild-caught zebrafish in Nepal π¦π
20.02.2026 16:04
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We summarised the many roles of material phase transitions in development (and they are not just mechanical π€)
19.02.2026 14:07
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Mutual information and task-relevant latent dimensionality
Estimating the dimensionality of the latent representation needed for prediction -- the task-relevant dimension -- is a difficult, largely unsolved problem with broad scientific applications. We cast ...
New preprint!
arxiv.org/abs/2602.08105
We use mutual information to find the shared dimensionality of shared latent space between two high-dimensional variables. Turning inference into optimization, we use it to figure out dofs in movies and critical scaling in Ising!
11.02.2026 19:19
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Advanced grad students + postdocs: apply for the 2026 #kitpqbio summer course, "Physical Principles of Morphogenesis in Plants and Animals," at buff.ly/OXXMKEv. Apply by Feb. 1.
Course directors Adrienne Roeder (Cornell) and Sebastian Streichan (UCSB)
19.11.2025 23:45
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Instructors include @akankshi.bsky.social, @nicolettapetridou.bsky.social, @dianapinheiro.bsky.social, @chloeroffay.bsky.social, & @streichan.bsky.social among others! π
30.01.2026 07:51
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Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etcβ¦. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasonsβ¦)
29.01.2026 17:24
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Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in thisπ§΅ www.nature.com/articles/s41... π€©
@poldresden.bsky.social @mpi-cbg.de
28.01.2026 16:10
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Next Monday 26th Jan, we are very excited to hear two talks from Margot Smit @likeyoda1.bsky.social and Susan Wopat @suewop.bsky.social!
Visit our website(ucammorphogenesisseries.com) for more details, and be sure to subscribe to our mailing list(lists.cam.ac.uk/sympa/info/u...). See you soon!!
23.01.2026 09:43
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Looking forward to sharing my postdoctoral work in just a little over a week at the UCAM Morphogenesis Series! ππ¬π¦
18.01.2026 22:36
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The Cambridge Morphogenesis Seminar Series is back! π
Check out the flyer for a great lineup of speakers for Lent Term 2026!
Don't forget to subscribe to our mailing list to get all the information, including the Zoom link. We are excited to see you again soon π
16.01.2026 14:38
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Feb 1 deadline approaching for our @kitp-ucsb.bsky.social QBio summer course on Physical Principles of Morphogenesis in Plants and Animals. @streichan.bsky.social
@maurazimmermann.bsky.social @maizel-lab.org @yusuke-mori.bsky.social @akankshi.bsky.social @nicolettapetridou.bsky.social
13.01.2026 23:36
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How does a uniform zygote reliably break symmetry?
How do initially identical cells diverge in cell-cycle timing and transcriptional state?
In our new paper in Nature Physics, we show that embryo geometry itself is sufficient to pattern early development.
www.nature.com/articles/s41...
12.01.2026 22:00
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A screenshot of the 'The hard truth about how hard it is to publish in Development' article PDF.
The hard truth about how hard it is to publish in Development
Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is βtoo hard to publish inβ by discussing the journal's review process.
doi.org/10.1242/dev....
12.01.2026 10:36
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Open-source atlas of fruit fly development DynamicAtlas is a high-res framework for morphological studies
πΉ M. F. Lefebvre, V. Jain-Sharma, N. Claussen & N. P. Mitchell et al @streichan.bsky.social lab University of California Santa Barbara in @natmethods.nature.com
β‘οΈ bpod.org.uk/archive/2026...
12.01.2026 09:36
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Why does life explore so few of the forms it could possibly take? Using fractal descriptors, this #scienceadvances paper shows that Earthβs biosphere clusters around simple shapes, reflecting deep evolutionary constraints. @artemyte.bsky.social @manlius.bsky.social www.science.org/doi/pdf/10.1...
11.01.2026 13:22
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Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series
Friday, January 9, 2026, 3:00pm - 4:00 pm Eastern Time
Priyom Adhyapok (Duke University)
A biological oscillator controls the pace of notochord segmentation
Zong-Yuan Liu (University of Michigan)
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
The next the Ethel Browne Harvey Postdoc Seminar will be this Friday, January 9 at 3 pm Eastern Time with Priyom Adhyapok @priyomadhyapok.bsky.social @duke-university.bsky.social and Zong-Yuan Liu @UMich. Register today and join us. bit.ly/4ncxr0M #SDBPostdocSeminar
07.01.2026 14:51
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Client Challenge
Also read the News & Views highlighting this work, here:
www.nature.com/articles/s41...
08.01.2026 20:44
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DynamicAtlas: a morphodynamic atlas of Drosophila development.
www.nature.com/articles/s41...
08.01.2026 20:44
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Priyom Adhyapok
Oscillator phases (circles) with averages (squares) on the unit circle as a function of time
.@priyomadhyapok.bsky.social of @duke-university.bsky.social will kick off the #SDBPostdocSeminar with her talk "A biological oscillator controls the pace of notochord segmentation" Image: Oscillator phases (circles) with averages (squares) on the unit circle as a function of time
07.01.2026 14:51
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How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? π€
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
05.01.2026 08:00
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Congrats Nikhil! This is truly amazing work and itβs great to see it out!
05.01.2026 16:24
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Thread highlights new work from @nikhil-mishra.bsky.social & @heisenbergcplab.bsky.social π
Link to open-access article: www.nature.com/articles/s41...
05.01.2026 12:53
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Very happy to finally see this out! :)
05.01.2026 12:39
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π¬ New paper in Developmental Biology π
Our researchers have now tested a largely ignored hypothesisβthat the geometry of an embryo drives its development. Read more in the π§΅below.
π· Zebrafish in ISTAβs Aquatic Facility.
05.01.2026 10:01
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We anticipate that this resource will be useful for the broad Drosophila community (and as a rich trove of data for theorists everywhere!)β¨β¨β¨β¨
More generally, we hope that the DynamicAtlas framework will provide a template for quantitative, dynamic analysis of morphogenesis in other living systems!
24.12.2025 10:39
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Dryad | Data: Morphodynamic atlas for Drosophila development
DynamicAtlas resources are all publicly available! Links below:
Datasets are on Dryad (please explore!!!)β¦β¨β¨doi.org/10.25349/D9W...
Python code is on Zenodoβ¦β¨β¨doi.org/10.5281/zeno...
MATLAB code is on GitHubβ¦β¨β¨github.com/npmitchell/d...
β¦and code tutorials are in the Supplementary Information.
24.12.2025 10:39
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