Andrea Sinz πŸ§ͺ's Avatar

Andrea Sinz πŸ§ͺ

@sinzandrea

Full (W3) Professor Pharm. Chem. & Bioanalytics at MLU Halle-Wittenberg; Center for Structural Mass Spectrometry https://agsinz.pharmazie.uni-halle.de https://rtg2467.uni-halle.de/ #teammassspec #massspec #ChemSky Structural proteomics, cross-linking MS

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16.11.2024
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Latest posts by Andrea Sinz πŸ§ͺ @sinzandrea

Each gene in CENTRA comes with its own radar plot visualizing key topological properties:
πŸ“‘ Centrality
🌿 Local fractality
πŸ›‘οΈ Robustness

Perfect for comparing genes across different biomedical topics.

22.01.2026 19:14 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Love this picture!πŸ‘πŸ‘

11.11.2025 16:57 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Helgas AlmhΓΌtte???

11.11.2025 15:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Great cooperation I am really proud of!πŸ§ͺ😊

10.11.2025 18:32 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Great talks on the first day of our retreat! It is fantastic to see the progress that has been made in the projects during the last year!πŸ§ͺ

10.11.2025 18:30 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

To be honest, when I see conferences announced that have a majority of male invited speakers, I think the organisers are not trying hard enough. We have so many excellent #FemalesinMS and resources available there is really no excuse for it anymore #massspec #teammassspec #lipidomics #metabolomics

27.10.2025 22:45 πŸ‘ 21 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0

▢️ I am now mainly active on LinkedIn. Looking forward to meeting you there @linkedin.com! πŸ§ͺ🧬🦠

31.10.2025 09:39 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
Life-changing eye implant helps blind patients read again The results are astounding and a major advance, say surgeons involved in international research using the pioneering technology.

Life-changing eye implant helps blind patients read again.
πŸ§ͺπŸ‘οΈ
www.bbc.com/news/article...

20.10.2025 12:17 πŸ‘ 25 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
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The world joined us and said, β€œNo Kings.”

19.10.2025 04:17 πŸ‘ 38371 πŸ” 13025 πŸ’¬ 1445 πŸ“Œ 1088
Poster Image with a woman yelling into a megaphone.; Title reads: Fight for Science. Bubbles read: 3:00pm, Rally, Oct 17th.; Subtitle reads: Health and Science for the People!; A pin emoji with text: 200 Independence Ave SW, Washington DC; a Virtual Call emoji with text: Join us virtually at:  bit.ly/4mXwrfY ; bottom corner has QR code and a logo for Stand Up For Science

Poster Image with a woman yelling into a megaphone.; Title reads: Fight for Science. Bubbles read: 3:00pm, Rally, Oct 17th.; Subtitle reads: Health and Science for the People!; A pin emoji with text: 200 Independence Ave SW, Washington DC; a Virtual Call emoji with text: Join us virtually at: bit.ly/4mXwrfY ; bottom corner has QR code and a logo for Stand Up For Science

FIGHT FOR SCIENCE RALLY ✊🌏
⏰ WHEN: October 17th, 2025
πŸ“WHERE: 200 Independence Ave SW, Washington DC!
RSVP to JOIN THE FIGHT IRL: zurl.co/LayiM ‼️

πŸ“² Join us Virtually!: zurl.co/Um47l

08.10.2025 13:36 πŸ‘ 322 πŸ” 171 πŸ’¬ 4 πŸ“Œ 68
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πŸ§ͺWhat a fantastic symposium with such amazing science! Thank you πŸ™ Andrea Graziadei, @claudio-iacobucci.bsky.social and Lolita Piersimoni, for getting this organized!πŸŽ‰πŸŽ‰πŸŽ‰
@humantechnopole.bsky.social
Next year this symposium will be held in San Francisco…
#teammassspec #academicsky #chemsky

08.10.2025 15:41 πŸ‘ 8 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ§ͺ Michal Sharon just gave a fantastic talk @ssp2025.bsky.social on how native MS can give detailed structural insights into the circulating 20S proteasome. πŸ‘ @humantechnopole.bsky.social #teammassspec #academicsky

07.10.2025 11:21 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ§ͺ Paola Picottigives a great keynote lecture on decoding the protein dance. What a fantastic first day of the @ssp2025.bsky.social at @humantechnopole.bsky.social in Milan!πŸ‘

06.10.2025 16:16 πŸ‘ 10 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

πŸ§ͺ
www.nature.com/articles/s41...

05.10.2025 08:10 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

πŸ§ͺ And this is the second Nature Communications @natcomms.nature.com paper where we contributed:
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social

05.10.2025 08:05 πŸ‘ 10 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Figure 3 from the paper with the caption: "Role of machine learning in de novo design of IDRs. (A) Machine-learning models can be trained on diverse data sources, from molecular dynamics simulations to annotations of cellular localization and protein structures from the Protein Data Bank. (B) Often implemented as neural networks using sequence-encoded features as input, these models can initially be trained on a limited region of sequence space as surrogate models. Through active learning, additional simulations are performed during the design campaign to generate new data, and the surrogate model is retrained on the expanded dataset to progressively improve its accuracy. (C) Machine-learning models have been developed to predict biophysical observables, biological annotations, and protein structures. When combined, machine-learning models can be used to identify a set of sequences that strike a trade-off between multiple design objectives, defining a Pareto front."

Figure 3 from the paper with the caption: "Role of machine learning in de novo design of IDRs. (A) Machine-learning models can be trained on diverse data sources, from molecular dynamics simulations to annotations of cellular localization and protein structures from the Protein Data Bank. (B) Often implemented as neural networks using sequence-encoded features as input, these models can initially be trained on a limited region of sequence space as surrogate models. Through active learning, additional simulations are performed during the design campaign to generate new data, and the surrogate model is retrained on the expanded dataset to progressively improve its accuracy. (C) Machine-learning models have been developed to predict biophysical observables, biological annotations, and protein structures. When combined, machine-learning models can be used to identify a set of sequences that strike a trade-off between multiple design objectives, defining a Pareto front."

New review on computational design of intrinsically disordered proteins πŸ–₯️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & πŸ‘΄

doi.org/10.48550/arX...

17.09.2025 16:17 πŸ‘ 48 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1

πŸ§ͺThis works impressively demonstrates the power of integrated approaches to gain important structural insights into GPCRs. XL-MS, biochemical assays, and MD simulations were combined in this study.
#pharmsky #chemsky #GPCR

20.09.2025 19:51 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

‼️ Our Nature Comm paper is finally online!πŸŽ‰
pubmed.ncbi.nlm.nih.gov/40973726/
I am so proud of this joint work with Anette Kaiser @unileipzig.bsky.social. We investigate the interactions of the Y2 receptor with NPY. Thank you all who contributed! πŸ‘ πŸ’ͺ
@unihalle.bsky.social #chemsky #academicsky

20.09.2025 19:45 πŸ‘ 16 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0
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Let’s be clear about what happened to Jimmy Kimmel Trump’s most brazen attack on free speech yet.

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

18.09.2025 14:10 πŸ‘ 61834 πŸ” 19675 πŸ’¬ 2005 πŸ“Œ 917

I absolutely love the Sagrada Familia; it is breathtaking. πŸ₯°

20.09.2025 09:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

#PhD

16.09.2025 17:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Actually, Alessio has two twins! Look at the picture: one is a real twin, the other one is not…can you tell who is who???πŸ˜‚πŸ˜‚πŸ˜‚

16.09.2025 12:25 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Jacopo, Alessio, and Andrea.

Jacopo, Alessio, and Andrea.

Alessio with his hat after the defense.

Alessio with his hat after the defense.

Alessio Di Ianni from our group just defended his thesis on studying intrinsically disordered proteins by XL-MS. Bravo!πŸŽ‰πŸŽ‰ Fantastic defense and discussion! πŸ‘ #proudPI @unihalle.bsky.social @humantechnopole.bsky.social #RTG2467 #Academicsky #pharmsky #chemsky

16.09.2025 12:23 πŸ‘ 17 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

This publication also counts for our SFB1664! 😁@snp2prot.bsky.social @unihalle.bsky.social @ipbhalle.bsky.social

13.09.2025 19:10 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

πŸ˜‚

13.09.2025 19:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Third Nature Comm paper accepted within two weeks…I have never had this beforeβ€¦πŸ˜œ

13.09.2025 16:30 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Bluesky

Suche dir so frΓΌh wie mΓΆglich gute und erfahrene Mentor*innen! Netzwerke von Frauen in der Wissenschaft sind extrem wichtig. @femalesinms.bsky.social

13.09.2025 16:26 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Our manuscript "Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport" has just been accepted at Nature Communications!πŸŽ‰πŸŽ‰ I feel truly honored to be part of this work that was headed by Panos Kastritis and Gary Sawers.More information to follow! @unihalle.bsky.social
#Academicsky

13.09.2025 11:49 πŸ‘ 19 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Green Chair Blue Chair
by me
#photography #streetphotography

12.09.2025 11:52 πŸ‘ 26 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0