Tobias Hohl, MD PhD

Truffle hunting, line dancing, yodelling…

It’s early…

Go Hawks! - @josephsunlab.bsky.social

Yes I am!

Check out this terrific paper by George Chamilos and colleagues on the role of albumin in defense against mucormycosis. It was a treat to write the preview with Katrina Mar.

Brilliant statement

I’ve been very impressed with how @ameracadpeds.bsky.social has been fighting the horrific misinformation and science denialism peddled by RFK Jr & his minions

🎓 Huge congratulations to Kathleen Mills from the @fungalspore.bsky.social Hohl Lab on successfully defending her thesis: "Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus" Her strong, dedicated presence in the program will truly be missed! 💫🧬

And a real doozy from the article:

"Most botanists from the mid-19th century viewed their study as a research backwater."

We're working hard here to change this long-held stereotype!

"You are my only friend in the debatable land of fungi”

Wonderful quote from by Mary Elizabeth Banning, a self-taught mycologist who described 23 new species of fungi in Maryland in the 19th century.

www.nytimes.com/2025/03/25/s...

#MicroSky #IDSky #ImmunoSky

#MicroSky #ImmunoSky #IDSky

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...

Basel, Switzerland

Love the generations!!

A fantastic GRC on the Immunology of Fungal Infections. Gordon Brown, @slg1717.bsky.social, Bernie Hube, Mihai Netea, Ilse Jacobsen, Jay Vyas, Rob Wheeler, @lableibundgut.bsky.social - missing former/future 🪑 Luigina Romani, Rebecca Drummond, Bruce Klein, Neil Gow& George Deepe #MicroSky #ImmunoSky

@fungalspore.bsky.social and @lableibundgut.bsky.social look forward seeing you in Ventura Beach!

doi.org/10.1093/infd...

High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro | Antimicrobial Agents and Che... ABSTRACT Posaconazole is a commonly used antifungal for the prophylaxis and treatment of invasive fungal infections. We previously demonstrated that the intracellular concentration of posaconazole in ...

doi.org/10.1128/aac....

It's reasonable to give 5 mg/kg ambisone + posa up front since posa load takes time. I generally don't use prolonged (>2 weeks) dual therapy for mucormycosis. I don't use 10 mg/kg for mucormycosis due to toxicities. The key here is to get isolate and perform AST to optimize therapy quickly.

If Mucorales are in the picture, I do not think that posa and isavu are equivalent. Posa IMHO is a better drug than isavu. For aspergillosis, posa and vori are my top choices, isavu OK too. I only use isavu when patient cannot tolerate posa or vori.

Acute-angle branching is mot consistent with aspergillosis. Were septations present? I would treat with posaconazole which is enriched in CNS-penetrating neutrophils. For a very, very long time. Would try to culture tissue for isolate for ID.

My family knows me all too well. This well-chosen gift hits close to home. May your science (funding) prayers be answered in 2025! #IDSky #ImmunoSky #MedSky #MicroSky

Merry Christmas! Happy Hanukah! Blending 🇨🇭tradition with 🕯️+ 🎄(Catskills grown and cut on Dec. 24).

Terrific opportunity with wonderful colleagues!

A photo of Fred Hutch Cancer Center in Seattle, with the Arnold buildling and "the Vessel" sculpture in front.

Mount Rainer surrounded by a field of wildflowers

📢 Brand new ID faculty position just posted @fredhutch.bsky.social in Seattle. Join our ID group that studies infections in immunocompromised hosts. The Emerald city has great academics, phenomenal facilities, outstanding collaborators - all in amazing surroundings.

apply.interfolio.com/159913

No need to duplicate. You're much further along. Just grab from mine...

Starting an MSKCC starter pack to build community on @bsky.app #MedSky #ImmunoSky

Welcome aboard!

Candida auris Infections | NEJM C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...

Candida auris Infectious by Lionakis & Chowdhary in NEJM
www.nejm.org/doi/full/10....

Would add @lableibundgut.bsky.social to the Mycology community.

I'd start here...https://go.bsky.app/FYRJn6M